Skip to main content
SpringerLink
Log in

Animal Models for Therapeutic Trials of Viral Myocarditis

  • Conference paper
Idiopathic Dilated Cardiomyopathy

Abstract

Clinically, viral myocarditis may appear in a wide variety of forms, ranging from a total lack of clinical manifestations to sudden, unexpected death. Myocarditis may be subacute or even chronic, leading to progressive myocardial failure and death [1, 2]. We have developed animal models for viral myocarditis using encephalomyocarditis (EMC) virus in which congestive heart failure developed in a range of the acute to subacute stages [5], and dilatation and hypertrophy as seen in dilated cardiomyopathy developed in the chronic stage [6]. Histologically, myocardial necrosis became apparent on day 7, cellular infiltration was most marked on day 14, and thereafter, inflammatory reaction decreased, and fibrosis appeared; calcification persisted to day 28. Marked myocardial fibrosis and hypertrophy of myocardial cells became evident on day 90. We have investigated the natural history and pathogenesis of viral myocarditis and assessed diagnostic methods and therapeutic and preventive interventions in these models [7–20, 23, 26–28, 30, 31, 34]. This review discusses our recent therapeutic trials of viral myocarditis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kawai C, Matsumori A, Kitaura Y, Takatsu T (1978) Viruses and the heart: viral myocarditis and cardiomyopathy. Prog Cardiol 7:141–162

    Google Scholar 

  2. Kawai C, Matsumori A, Fujiwara H (1987) Myocarditis and dilated cardiomyopathy. Annu Rev Med 38:221–239

    Article  PubMed  CAS  Google Scholar 

  3. Kino T, Hatanaka H, Miyata S, Inamura N, Nishiyama M, Yajima T, Goto T, Okuhara M, Kohsaka M, Aoki H, Ochiai T (1987) FK-506, a novel immunosuppressant isolated from a streptomyces: immunosuppressive effect of FK-506 in vitro. J Antibiot (Tokyo) 40:1256–1265

    CAS  Google Scholar 

  4. Kirkman RL, Barrett LV, Gaulton GN, Kelley VE, Koltun WA, Schoen FJ, Ythier A, Strom TB (1985) The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection. Transplantation 40:719–722

    Article  PubMed  CAS  Google Scholar 

  5. Matsumori A, Kawai C (1982) An experimental model for congestive heart failure following encephalomyocarditis virus myocarditis in mice. Circulation 65:1230–1235

    Article  PubMed  CAS  Google Scholar 

  6. Matsumori A, Kawai C (1982) An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus. Circulation 66:355–360

    Article  PubMed  CAS  Google Scholar 

  7. Matsumori A, Kawai C (1984) Animal models of congestive heart failure and congestive (dilated) cardiomyopathy due to viral myocarditis in mice. In: Bolte H-D (ed) Viral heart disease. Springer, Berlin Heidelberg New York, pp 35–56

    Google Scholar 

  8. Matsumori A, Wang H, Abelmann WH, Crumpacker CS (1985) Treatment of viral myocarditis with ribavirin in an animal preparation. Circulation 71:834–839

    Article  PubMed  CAS  Google Scholar 

  9. Matsumori A, Kawai C, Crumpacker CS, Abelmann WH (1987) The use of animal models for preventive and therapeutic trials of viral myocarditis. In: Kawai C, Abelmann WH, Matsumori A (eds) Cardiomyopathy update 1. Pathogenesis of myocarditis and cardiomyopathy. University of Tokyo Press, Tokyo, pp 37–47

    Google Scholar 

  10. Matsumori A, Crumpacker CS, Abelmann WH, Kawai C (1987) Virus vaccine and passive immunization for the prevention of viral myocarditis in mice. Jpn Circ J 51:1362–1364

    Article  PubMed  CAS  Google Scholar 

  11. Matsumori A, Crumpacker CS, Abelmann WH (1987) Pathogenesis and preventive and therapeutic trials in an animal model of dilated cardiomyopathy induced by a virus. Jpn Circ J 51:661–664

    Article  PubMed  CAS  Google Scholar 

  12. Matsumori A, Crumpacker CS, Abelmann WH (1987) Prevention of viral myocarditis with recombinant human leukocyte interferon-α A/D in a murine model. J Am Coll Cardiol 9:1320–1325

    Article  PubMed  CAS  Google Scholar 

  13. Matsumori A, Okada I, Kawai C, Crumpacker CS, Abelmann WH (1988) Animal models for therapeutic trials of viral myocarditis: effect of ribavirin and alpha interferon on coxsackievirus B3 and encephalomyocarditis virus myocarditis. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 377–384

    Chapter  Google Scholar 

  14. Matsumori A, Kawai C (1989) Immunomodulating therapy in experimental myocarditis. Springer Semin Immunopathol 11:77–88

    Article  PubMed  CAS  Google Scholar 

  15. Matsumori A, Ohkusa T, Matoba Y, Okada I, Yamada T, Kawai C, Tamaki N, Watanabe Y, Yonekura Y, Endo K, Konishi J, Khaw B, Haber E (1989) Myocardial uptake of antimyosin monoclonal antibody in a murine model of viral myocarditis. Circulation 79:400–405

    Article  PubMed  CAS  Google Scholar 

  16. Matsumori A, Hoshino T, Kishimoto C, Kawai C (1990) Morphological features and electric disturbances in experimental viral myocarditis. In: Olsen EGJ, Sekiguchi M (eds) Proceeding of the 2nd international symposium on cardiomyopathy and myocarditis. University of Tokyo Press, Tokyo, pp 217–222

    Google Scholar 

  17. Matsumori A, Matoba Y, Tomioka N, Kawai C (1990) Experimental viral myocarditis: immunopathogenetic aspects. In: Baroldi G, Camerini F, Goodwin JF (eds) Advances in cardiomyopathies. Springer, Berlin Heidelberg New York, pp 181–189

    Google Scholar 

  18. Matsumori A, Suzuki H, Kawai C (1990) Beneficial effects of captopril in coxsackievirus myocarditis. Circulation 82:1882

    PubMed  CAS  Google Scholar 

  19. Matsumori A, Yamada T, Kawai C (1991) Immunodulating therapy in viral myocarditis: effects of tumor necrosis factor, interleukin-2 and anti-interleukin-2 receptor antibody in an animal model. Eur Heart J 12 [Suppl D]:203–205

    PubMed  Google Scholar 

  20. Matsumori A, Sato Y (1991) Treatment of coxsackievirus B3 myocarditis by a new immunoactive peptide, FK-565 in a murine model. Circulation 84 [Suppl II]:633

    Google Scholar 

  21. Matsuzaki M, Kohno M, Matsuda Y, Ogawa H, Ozaki M, Toma Y, Fujii H, Kusukawa R (1989) The effect of vasodilators on hemodynamics and renal circulation in stable chronic heart failure. Jpn Circ J 53:463–464

    Google Scholar 

  22. Mine Y, Yokota Y, Wakai Y, Fukada S, Nishida M, Goto S, Kuwahara S (1983) Immuno- active peptides, FK156 and FK565. I. Enhancement of host resistance to microbial infec- tion in mice. J Antibiot (Tokyo) 36:1045–1050

    CAS  Google Scholar 

  23. Monrad ES, Matsumori A, Murphy JC, Fox JG, Crumpacker CS, Abelmann WH (1986) Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus. Circulation 73:1058–1064

    Article  PubMed  CAS  Google Scholar 

  24. Rezkalla S, Kloner RA, Khatib G, Smith F, Khatib R (1988) Effect of metoprolol in acute coxsackievirus B3 murine myocarditis. J Am Coll Cardiol 12:412–414

    Article  PubMed  CAS  Google Scholar 

  25. Rezkalla S, Kloner RA, Khatib G, Khaib R (1990) Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. Circulation 81:1039–1047

    Article  PubMed  CAS  Google Scholar 

  26. Sato Y, Maruyama S, Kawai C, Matsumori A (1992) Effect of immunostimulant therapy on acute viral myocarditis in an animal model. Am Heart J 124:428–434

    Article  PubMed  CAS  Google Scholar 

  27. Suzuki H, Matsumori A (1990) Myocardial injury due to viral myocarditis improved by captopril in mice. Circulation 82 [Suppl III]:674

    Google Scholar 

  28. Suzuki H, Matsumori A (1991) Effects of angiotensin-converting enzyme inhibitors on myocardial injury and congestive heart failure due to myocarditis in mice: comparison with captopril and enalapril. Circulation 84 [Suppl II]:634

    Google Scholar 

  29. Talmadge JE, Chirigos MA (1985) Comparison of immunomodulatory and immuno- therapeutic properties of biologic response modifiers. Springer Semin Immunopathol 204:1–15

    Google Scholar 

  30. Tominaga M, Matsumori A, Okada I, Yamada T, Kawai C (1991) β-Blocker treatment of dilated cardiomyopathy: beneficial effect of carteolol in mice. Circulation 86:2021–2028

    Google Scholar 

  31. Tomioka N, Kishimoto C, Matsumori A, Kawai C (1986) Effects or prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol 7:868–872

    Article  PubMed  CAS  Google Scholar 

  32. Waagstein F, Hjalmarson A, Varnauskas E, Wallentin I (1975) Effect of chronic β-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J 37:1022–1036

    Article  PubMed  CAS  Google Scholar 

  33. Waagstein F, Caidahi K, Wallentin I, Bergh CH, Hjalmarson A (1989) Long-term β-blockade in dilated cardiomyopathy: effects of short- and long-term metoprolol treat- ment followed by withdrawal and readministration of metoprolol. Circulation 80:551–563

    Article  PubMed  CAS  Google Scholar 

  34. Yamada T, Matsumori A (1990) Therapeutic effect of bunazosin on experimental viral myocarditis in mice evaluated by antimyosin uptake. Circulation 82 [Suppl III]:673

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Division Department, Internal Medicine Kyoto University, 54 Kawaracho Shogoin, 606, Sakyo-ku, Kyoto, Japan

    A. Matsumori

Authors
  1. A. Matsumori
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Postfach 3742, W-3400, Göttingen, Fed. Rep. of Germany

    Hans-Reiner Figulla

  2. Institut für Pathologie, Universität Tübingen, W-7400, Tübingen, Fed. Rep. of Germany

    Reinhard Kandolf

  3. Max-Planck-Institut für Biochemie, W-8033, Martinsried, Fed. Rep. of Germany

    Reinhard Kandolf

  4. Department of Pathology and Microbiology, University of Nebraska, Medical Center, 600 South 42nd Street, Omaha, NE, 68198-6495, USA

    Bruce McManus Ph.D., M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Matsumori, A. (1993). Animal Models for Therapeutic Trials of Viral Myocarditis. In: Figulla, HR., Kandolf, R., McManus, B. (eds) Idiopathic Dilated Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77891-9_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77891-9_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77893-3

  • Online ISBN: 978-3-642-77891-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation