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Immunomodulating therapy in experimental myocarditis

  • Experimental Studies In Myocarditis And Cardiomyopathy
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Conclusion

The use of immunosuppressive therapy with prednisolone, cyclophosphamide, cyclosporine or anti-thymocyte serum in experimental virus myocarditis induced by coxsackievirus or EMC virus was associated with greater mortality when administered early in illness. Beneficial effects were not seen by later administration of these agents. Thus, although it would be rather difficult to interpolate the results of animal experiments to man, clinical trials of immunosuppressive therapy against inflammatory myocarditis should be carried out with great caution and only in the setting of a carefully controlled clinical trial.

Nonsteroid anti-inflammatory drugs, libuprofen, salicylates and indomethacin, and an immunopotentiating drug, levamisole, worsened experimental coxsackievirus B3 myocarditis and should not be used in acute myocarditis due to Coxsackie B viruses. Interferon has a beneficial effect against viral myocarditis due to coxsackievirus and EMC virus and may be clinically applicable.

Moreover, with the development of clinically applicable antiviral agents, immunosuppressive or anti-inflammatory therapy against viral myocarditis, and dilated cardiomyopathy as its sequelae, may well have a different clinical scope in the future.

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Authors and Affiliations

  1. The Third Division, Department of Internal Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Akira Matsumori & Chuichi Kawai

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  1. Akira Matsumori
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  2. Chuichi Kawai
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Matsumori, A., Kawai, C. Immunomodulating therapy in experimental myocarditis. Springer Semin Immunopathol 11, 77–88 (1989). https://doi.org/10.1007/BF00197087

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  • DOI: https://doi.org/10.1007/BF00197087

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