Abstract
Enterovirus infections of humans are common [31], with the majority being asymptomatic [6]. These viruses, particularly the coxsackieviruses group B (CVB) are associated with diseases of the heart [26, 27], with acute myocarditis occurring in up to 5% of infected individuals [26, 40]. Neonatal myocarditis is a severe disease and contributes to mortality in infants and young children [6, 26, 27]. Among the CVB, coxsackievirus B3 (CVB3) is most frequently associated with acute myocarditis [34]. Acute disease can progress to chronic myocarditis, and clinical laboratory data suggest that some cases of chronic disease develop into idiopathic dilated cardiomyopathy [26, 27, 33, 35].
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References
Beck MA, Chapman NM, McManus BM, Mullican JC, Tracy S (1990) Secondary enterovirus infection in the murine model of myocarditis. Am J Pathol 136:669–681
Beck MA, Tracy SM (1989) Murine cell-mediated immune response recognizes an enterovirus group-specific antigen(s). J Virol 63:4148–4156
Beck MA, Tracy SM (1990) Evidence for a group-specific enteroviral antigen(s) recognized by human T cells. J Clin Microbiol 28:1822–1827
Beck MA, Tracy S, Coller BA, Chapman NM, Hufnagel G, Johnson JE, Lomonossoff (1992) Comoviruses and enteroviruses share a T cell epitope. Virology 186:238–246
Beisel KW, Traystman MD (1988) Viral myocarditis: immunogenetic and autoimmune aspects. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 148–159
Cherry JD (1987) Enteroviruses: polioviruses (poliomyelitis), coxsackieviruses, echoviruses, and enteroviruses. In: Feigin RD, Cherry JD (eds) Textbook of pediatric diseases. Saunders, Phladelphia, pp 1729–1790
Chow LH, Gauntt CJ, McManus BM (1991) Differential effects of myocarditic variants of coxsackievirus B3 in inbred mice: a pathologic characterization of heart tissue damage. Lab Invest 64:55–64
Crowell RL, Landau BJ (1983) Receptors in the initiation of picornavirus infections. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology, vol 18. pp 1–42
Frisk G, Nilsson E, Ehrnst A, Diderholm H (1989) Enterovirus IgM detection: specificity of μ-antibody-capture radioimmunoassays using virions and procapsids of coxsackie B virus. J Virol Methods 24:191–202
Gauntt CJ (1988) The possible role of viral variants in pathogenesis. In: Friedman H, Bendinelli M (eds) Coxsackieviruses - a general update. Plenum, New York, pp 159–179
Gauntt CJ, Arizpe HM, Higdon AL, Rozek MM, Crawley R, Cunningham MW (1991) Anti-coxsackievirus B3 neutralizing antibodies with pathologic potential. Eur Heart J 12 [Suppl D]:124–129
Gauntt CJ, Godeny EK, Lutton CW (1988) Host factors regulating viral clearance. Pathol Immunopathol Res 7:251–265
Gauntt CJ, Godeny EK, Lutton CW, Arizpe HM, Chapman NM, Tracy SM, Revtyak GE, Valente AJ, Rozek MM (1988) Mechanism(s) of coxsackievirus-induced acute myocarditis in the mouse. In: de la Maza LM, Peterson E (eds) Medical virology VIII. Erlbaum, Hillsdale, pp 161–182
Gauntt GJ, Higdon AL, Arizpe HM, Tamayo MR, Crawley R, Henkel RD, Pereira ME A, Tracy SM, Cunningham MW (1992) Epitopes shared between coxsackievirus B3 (CVB3) and normal heart tissue contribute to CVB3-induced murine myocarditis. In: Rose NR, Baughman KL, Herskowitz A, Newmann DA (eds) immune mediated heart disease. Springer, Berlin Heidelberg New York (in press)
Gauntt CJ, Lutton CW, Arizpe HM, Higdon AH, Tracy SM (1991) Autoimmune reactions in coxsackievirus B3-induced murine myocaditis. Life Sci Adv 10:23–31
Gauntt CJ, Lutton CW, Revtyak GE, Valente AJ, Fernandes AN, Arizpe HM, Rozek MM (1988) Induction of soluble mediators during coxsackievirus B3 replication in vitro and in vivo. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelbergy New York, pp 93–104
Godeny EK, Arizpe HM, Gauntt CJ (1988) Characterization of the antibody response in vaccinated mice protected against coxsackievirus B3-induced myocarditis. Viral Immunol 1:305–314
Godeny EK, Gauntt CJ (1986) Involvement of natural killer cells in coxsackievirus B3- induced murine myocarditis. J Immunol 137:1695–1702
Godeny EK, Gauntt CJ (1987) In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis. Am J Pathol 129:267–276
Godeny EK, Sprague EA, Schwartz CJ, Gauntt CJ (1986) Coxsackievirus group B replication in cultured fetal baboon aortic smooth muscle cells. J Med Virol 20:135–149
Grist NR (1988) Epidemiology and pathogenicity of coxsackieviruses. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 26–32
Halstead SB (1988) Pathogenesis of dengue: challenges to molecular biology. Science 239:476–481
Herskowitz A, Wolfgram LJ, Rose NR, Beisel KW (1987) Coxsackievirus B3 murine myocarditis-marked strain differences in histopathologic features of early and late phase myocarditis. J Am Coll Cardiol 9:1311–1319
Huber SA, Weller A, Herzum M, Lodge PA, Estrin M, Simpson K, Guthrie M (1988) Immunopathogenic mechanisms in experimental picornaviros-induced autoimmunity. Pathol Immunopathol Res 7:279–291
Katze MG, Crowell RL (1980) Immunological studies of the group B coxsackieviruses by the sandwich enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation. J Gen Virol 50:357–367
Leslie K, Blay R, Haisch C, Lodge A, Weller A, Huber S (1989) Clinical and experimental aspects of viral myocarditis. Clin Microbiol Rev 2:191–203
McManus BM, Gauntt CJ, Cassling RS (1987) Immunopathologic basis of myocardial injury. Cardiovasc Clin 18:163–184
Mitchell DM, McMichael AJ, Lamb RA (1985) The immunology of influenza. Br Med Bull 41:80–86
Murphy BR, Chanock RM (1991) Immunization against viruses. In: Fields BN, Knipe DM (eds) Fundamental virology, 2nd edn. Raven, New York, pp 371–404
Neu N, Rose NR, Beisel KW, Herskowitz A, Gurri-Glass G, Craig SW (1987) Cardiac myosin induces myocarditis in genetically predisposed mice. J Immunol 139:3630–3636
Pallansch MA (1988) Epidemiology of group B coxsackieviruses. In: Bendinelli M, Friedman H (eds) Coxsackieviruses - a general update. Plenum, New York, pp 399–417
Pattison JR (1983) Tests for coxsackie B virus-specific IgM. J Hyg 90:327–332
Reyes MP, Lerner AM (1988) Myocarditis. Clinical and experimental correlates. In: Bendinelli M, Friedman H (eds) Coxsackieviruses - a general update. Plenum, New York, pp 253–270
Rose NR, Neu N, Neumann DA, Herskowitz A (1988) Myocarditis: a postinfectious autoimmune disease. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 139–147
See DM, Tilles JG (1991) Viral myocarditis. Rev Infect Dis 13:951–956
Su H, Spangrude GJ, Caldwell HD (1991) Expression of Fcy RIII on HeLa 229 cells: possible effect on in vitro neutralization of Chlamydia trachomatis. Infect Immun 59: 3811–3814
Tracy S, Chapman NM, Beck MA (1991) Molecular biology and pathogenesis coxsackie B viruses. Rev Med Virol 1:145–154
van Houten N, Huber S (1989) Role of cytotoxic T cells in exptl. myocarditis. Springer Semin Immunopathol 11:61–68
Wolfgram LJ, Beisel KW, Herskowitz A, Rose NR (1986) Variations in the susceptibility to coxsackievirus B3-induced myocarditis among different strains of mice. J Immunol 136:1846–1852
Wolfgram LJ, Rose NR (1989) Coxsackievirus infection as a trigger of cardiac autoimmunity. Immunol Res 8:61–80
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Gauntt, C.J. et al. (1993). Specific and Nonspecific Heart Defenses in Enteroviral Infections. In: Figulla, HR., Kandolf, R., McManus, B. (eds) Idiopathic Dilated Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77891-9_28
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