Abstract
Colicin V was the first colicin to be described in the literature. In 1925, Gratia described a factor which he called factor V which was biologically active against “coli” (Gratia, 1925). This factor was studied further and given the name “colicin V” (Fredericq et a.., 1949), but complete characterization was hindered by the apparent instability of the protein. As more was learned about the properties of other colicins such as A, El, and I, it became evident that colicin V (ColV) did not share most of the properties which had come to be associated with colicins. ColV is not SOS inducible, it is much smaller (6 kd) than other colicins, and it does not utilize a lysis protein for its release (Gilson et a.., 1990). Instead, it requires a set of dedicated export proteins. By these criteria, ColV more appropriately belongs to the related family of antimicrobial agents called microcins. For these reasons, we classify ColV as a microcin. But, for historical reasons, we feel it appropriate that its name remain unchanged.
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References
Bachmann BJ (1990) Linkage map of Escherichia col. K-12, Edition 8. Microbiol Rev 54:130–197
Blight MA, Holland IB (1990) Structure and function of haemolysin B, P-glycoprotein and other members of a novel family of membrane translocators. Mol Microbiol 4:873–880
Chehade H, Braun V (1988) Iron-regulated synthesis and uptake of colicin V. FEMS Microbiol Lett 52:177–182
Davies JK, Reeves P (1975) Genetics of resistance to colicins in Escherichia coli K-12: cross-resistance among colicins of group B. J Bacteriol 123:96–101
Fath MJ, Skvirsky R, Kolter R (1991) Functional complementation between bacterial MDR-like export proteins: colicin V, α-hemolysin and Erwini. protease. J Bacteriol 173:7549–7556
Feng D-F, Doolittle RF (1987) Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J Mol Evol 25:351–360
Fredericq P, Joiris E, Betz-Barreau M, Gratia A (1949) Researche des germes proucteurs do colicins dans les selles de malades atteints de fievre paratyphoide B. C R Soc Biol 143:556–559
Frick KK, Quackenbush RL, Konisky J (1981) Cloning of immunity and structural genes for colicin V. J Bacteriol 148:498–507
Garrido MC, Herrero M, Kolter R, Moreno F (1988) The export of the DNA replication inhibitor microcin B17 provides immunity for the host cell. EMBO J 7:1853–1862
Gilson L (1990) Signal Sequence-Independent Export of Colicin V. Ph.D. Thesis, Harvard University
Gilson L, Mahanty HK, Kolter R (1987) Four plasmid genes are required for colicin V synthesis, export, and immunity. J Bacteriol 169:2466–2470
Gilson L, Mahanty HK, Kolter R (1990) Genetic analysis of an MDR-like export system: the secretion of colicin V. EMBO J 9:3875–3884
Gratia A (1925) Sur un remarquable exemple d’antagonisime entr deux souches do Colibacille. C R Soc Biol 93:1040–1041
Gray L, Baker K, Kenny B, Mackman N, Haigh R, Holland IB (1989) A novel C-terminal signal sequence targets Escherichia col. haemolysin directly to the medium. J Cell Sci Suppl 11:45–57
Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP (1990) Binding Protein- Dependent Transport Systems. J Bioenerg Biomemb 22:571–592
Holland IB, Blight MA, Kenny B (1990) The mechanism of secretion of hemolysin and other polypeptides from Gram-negative bacteria. J Bioenerg Biomemb 22:473–491
Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, Higgins CF (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346:362–365
Mackman N, Nicaud J-M, Gray L, Holland IB (1985) Identification of polypeptides required for the export of haemolysin 2001 from E. coli. Mol Gen Genet 210:529–536
Mimura CS, Holbrook SR, Ames GF-L (1991) Structural model of the nucleotide-binding conserved component of periplasmic permeases. Proc Nat Acad Sci USA 88:84–88
Pugsley AP, d’Enfert C, Reyss I, Kornacker MG (1990) Genetics of extracellular protein secretion by Gram-negative bacteria. Ann Rev Genet 24:67–90
Walker JE, Sarste M, Runswick MJ, Gay NJ (1982) Distantly related sequences in the α- and β- subunits of ATP synthase, myosin kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J 1:945–951
Wandersman C, Delepelaire P (1990) TolC, an Escherichia col. outer membrane protein required for hemolysin secretion. Proc Natl Acad Sci USA 87:4776–4780
Wickner W, Driessen AJM, Hartl F-U (1991) The enzymology of protein translocation across the Escherichia col. plasma membrane. Ann Rev Biochem 60:101–124
Yang CC, Konisky J (1984) Colicin V-treated Escherichia col. does not generate membrane potential. J Bacteriol 158:757–759
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© 1992 Springer-Verlag Berlin Heidelberg
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Fath, M.J., Skvirsky, R., Gilson, L., Mahanty, H.K., Kolter, R. (1992). The Secretion of Colicin V. In: James, R., Lazdunski, C., Pattus, F. (eds) Bacteriocins, Microcins and Lantibiotics. NATO ASI Series, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76974-0_29
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DOI: https://doi.org/10.1007/978-3-642-76974-0_29
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