Abstract
In peripheral arterial occlusive disease systemic changes in neutrophil function suggestive of cell activation have been found [10]. Furthermore, it has been shown that intermittent claudication causes additional local alterations of neutrophil function [12]. Recent experimental results suggest that neutrophil activation may promote interactions between leucocytes, platelets, and endothelial cells [2, 3, 5, 6, 8]. These cell-cell interactions appear to involve an ongoing release of predominantly leucocyte-derived toxic compounds [15], resulting in progressive microvascular injury during ischaemia.
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© 1991 Springer-Verlag Berlin Heidelberg
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Neumann, FJ. et al. (1991). Effect of Intra-arterial and Intravenous Application of Prostaglandin E1 on Neutrophil Function in Peripheral Arterial Occlusive Disease. In: Diehm, C., Sinzinger, H., Rogatti, W. (eds) Prostaglandin E1 . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76910-8_7
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DOI: https://doi.org/10.1007/978-3-642-76910-8_7
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