Prostaglandin E1

New Aspects on Pharmacology, Metabolism and Clinical Efficacy

  • Curt Diehm
  • Helmut Sinzinger
  • Waltraud Rogatti
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XI
  2. M. Braun, L. Bruch, P. Ney, G. Torsello, K. Schrör
    Pages 12-20
  3. F.-J. Neumann, T. Weiss, J. Mollenhauer, M. Schneider, I. Ott, H.-M. Haupt et al.
    Pages 49-57
  4. T. Weiss, J. Griesshaber, W. Rogatti, O. Kistner, E. Hsu, T. Jansen et al.
    Pages 82-90
  5. W. Hepp, S. von Bary, D. Corovic, C. Diehm, E. Mühe, G. Rudofsky et al.
    Pages 101-108
  6. Back Matter
    Pages 115-117

About these proceedings

Introduction

Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour­ able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi­ 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.

Keywords

Lipoprotein Prostaglandin E1 Verschlußkrankheit blood cardiovascular cardiovascular system circulation endothelium kinetics lipide metabolism pharmacokinetics pharmacology research smooth muscle

Editors and affiliations

  • Curt Diehm
    • 1
  • Helmut Sinzinger
    • 2
  • Waltraud Rogatti
    • 3
  1. 1.Med. Klinik im Rehabilitationskrankenhaus KarlsbadKarlsbadGermany
  2. 2.Wilhelm-Auerswald-Atheroskleroseforschungsgruppe WienWienGermany
  3. 3.Köln 91Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76910-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-54524-8
  • Online ISBN 978-3-642-76910-8
  • About this book