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Molecular Genetics and Familial Arterial Hypertension

  • Conference paper
Genetic Approaches to Coronary Heart Disease and Hypertension

Summary

Human essential hypertension is a heterogeneous disorder of multifactorial origin. Genetic susceptibility plays an important role in the development of the disease and it has been estimated, from family and twin studies, that about 30% of the observed variation in blood pressure in the population is genetically determined The unimodal distribution of blood pressure in the general population as well as in the offspring of hypertensive parents, suggests that several genes are probably involved in genetic predisposition. Polymorphic variations in the structure of the genes involved in blood pressure regulation may be the origin of hypertension. One way of identifying these genes is to examining the role of potential candidate genes which influence blood pressure regulation and for which molecular molecular probes are available.

We have summarized in this chapter the results of three different genetic studies in which we have evaluated the effect of allelic variation on candidate genes, either on blood pressure level or on the phenotypic expression of these genes.

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Authors
  1. F. Soubrier
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  2. X. Jeunemaître
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  3. B. Rigat
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  4. F. Cambien
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  5. P. Corvol
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Editor information

Editors and Affiliations

  1. Institute of Medical Genetics, UllevalHospital, University of Oslo, Oslo, Norway

    Kare Berg M. D., Ph. D.

  2. World Health Organization, Avenue Appia, 1211, Geneva 27, Switzerland

    Victor Bulyzhenkov

  3. Fondation IPSEN pour la Recherche, Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen

  4. INSERM Unit 36, Collège de France, 3 rue d’Ulm, F-75005, Paris, France

    Pierre Corvol M. D.

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© 1991 Springer-Verlag Berlin Heidelberg

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Soubrier, F., Jeunemaître, X., Rigat, B., Cambien, F., Corvol, P. (1991). Molecular Genetics and Familial Arterial Hypertension. In: Berg, K., Bulyzhenkov, V., Christen, Y., Corvol, P. (eds) Genetic Approaches to Coronary Heart Disease and Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76891-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-76891-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76893-4

  • Online ISBN: 978-3-642-76891-0

  • eBook Packages: Springer Book Archive

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