Genetic Approaches to Coronary Heart Disease and Hypertension

  • Kare Berg
  • Victor Bulyzhenkov
  • Yves Christen
  • Pierre Corvol
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XIV
  2. A. G. Motulsky, W. Burke
    Pages 1-7
  3. R. R. Williams, S. C. Hunt, S. J. Hasstedt, P. N. Hopkins, L. L. Wu, M. C. Schumacher et al.
    Pages 8-19
  4. F. Soubrier, X. Jeunemaître, B. Rigat, F. Cambien, P. Corvol
    Pages 27-37
  5. T. W. Kurtz, L. Simonet, V. Křen, M. Pravenec
    Pages 38-59
  6. C. D. Sigmund, C. A. Jones, J. R. Fabian, C. Wu, C. M. Kane, M. K. Ellsworth et al.
    Pages 60-73
  7. J. Peters, M. Bader, D. Ganten, J. Mullins
    Pages 74-80
  8. Y. Yamori, Y. Nara, T. Nabika, K. Ikeda, K. Matsumoto
    Pages 81-97
  9. H. Hamaguchi, S. Kikuchi, H. Yanagi, T. Matsunaga, Y. Yamanouchi, A. Nakagawa et al.
    Pages 110-126
  10. V. A. Koshechkin, C. B. Hudaiberdyev, V. A. Kabakova, S. V. Panin, T. A. Rozhkova, E. Y. Solovjova
    Pages 127-142
  11. R. Lawn
    Pages 143-151
  12. Back Matter
    Pages 157-159

About these proceedings

Introduction

Cardiovascular diseases are the principal cause of mortality in many developed countries and are increasing in importance in developing countries where communicable diseases are being brought under control. It is estimated that coronary heart disease (CRD) and cerebrovascular diseases are responsible for between 40-50% of all deaths. Righ blood pressure is common in all industrialized societies and contributes importantly to CRD. It is well known that genetic factors play an important role in the etiology and pathogenes es of cardiovascular diseases and contribute to an individual's susceptibility or resistance to the disease. The application of modern genetic techniques has resulted in the identification of polymorphie markers that are involved in the normal regulation and function of the cardiovascular system. Many of these may contribute to the individual differences in the risk for CRD and hypertension. It is now known that several risk factors or protective factors with respect to cardiovascular diseases are strongly influenced by genes, and it is now possible to identify individual genes contributing to cardiovascular risk. A large bank of genetic knowledge relevant to CRD and hypertension has become available during the past years. As a result, it is now believed that CRD, for example, could be a good model for a feasibility study to determine a way by which preventive measures can be applied.

Keywords

arterial hypertension artery atherosclerosis cardiovascular cardiovascular system coronary heart disease gene therapy genes genetics heart heart disease hypertension molecular genetics stroke vascular disease

Editors and affiliations

  • Kare Berg
    • 1
  • Victor Bulyzhenkov
    • 2
  • Yves Christen
    • 3
  • Pierre Corvol
    • 4
  1. 1.Institute of Medical Genetics, UllevalHospitalUniversity of OsloOsloNorway
  2. 2.World Health OrganizationGeneva 27Switzerland
  3. 3.Fondation IPSEN pour la RechercheThérapeutiqueParis CedexFrance
  4. 4.INSERM Unit 36Collège de FranceParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76891-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76893-4
  • Online ISBN 978-3-642-76891-0
  • About this book