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Nerve Growth Factor Function in the Central Nervous System

  • Chapter
Neuronal Growth Factors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 165))

Abstract

A complete understanding of NGF function in the CNS does not exist. Instead, there is a collection of observations based on experiments conducted in the PNS and CNS, although more definitive results have come from experiments in the PNS. The conclusion that NGF is a neurotropic factor in the PNS biased experimental design and interpretation of results when a function for NGF in the CNS was sought. An example of design and interpretation bias is the very significant paper by Schwab et al. (1979), showing for the first time retrograde transport of NGF in cholinergic neurons. These authors entitled the manuscript “Nerve growth factor (NGF) in the CNS: absence of specific retrograde transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra”, documenting the expectation of retrograde transport in catecholamine neurons of the CNS, as in the PNS. Subsequent experiments, reviewed here, support a neurotrophic role for NGF in the CNS, although in the cholinergic rather than catecholaminergic system of CNS neurons.

The research presented in this manuscript was supported by NIA AGO 6988; NIA AGO 0353A (MHT); Office of Naval Research; State of California DHHS; the Pew Foundation; and the McKnight Foundation

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Authors and Affiliations

  1. Department of Neurosciences M-024, University of California at San Diego, La Jolla, CA, 92093, USA

    F. H. Gage, M. H. Tuszynski, K. S. Chen & A. M. Fagan

  2. Laboratory of Biological Chemistry, Gerontology Research Center, 4940 Eastern Ave., Baltimore, MD, 21224, USA

    G. A. Higgins

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  1. F. H. Gage
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  2. M. H. Tuszynski
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  3. K. S. Chen
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  4. A. M. Fagan
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  5. G. A. Higgins
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Editors and Affiliations

  1. Department of Physiology and Biophysics, University of Washington, 98195, Seattle, WA, USA

    Mark Bothwell MD

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Gage, F.H., Tuszynski, M.H., Chen, K.S., Fagan, A.M., Higgins, G.A. (1991). Nerve Growth Factor Function in the Central Nervous System. In: Bothwell, M. (eds) Neuronal Growth Factors. Current Topics in Microbiology and Immunology, vol 165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75747-1_5

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