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Identification of the Effective Dose of Inhaled Toxicants: General and Specific Problems

  • Conference paper
Assessment of Inhalation Hazards

Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

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Abstract

The establishment of a dose-effect relationship is based on a parameter of dose. This may be difficult to assess when an inhaled toxicant is being considered. The problem is generally known for particles, and for inhaled gases and vapors. A classical example of the latter is vinyl chloride. Vinyl chloride is a gaseous compound and known as a carcinogen in man and in experimental animals; its biochemical activation mechanism has been clarified. Vinyl chloride requires metabolic transformation to its epoxide, which is the ultimate genotoxic carcinogen at the DNA level (for review, see Bolt 1988).

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Authors and Affiliations

  1. Institut für Arbeitsphysiologie, Universität Dortmund, Ardeystr. 67, D-4600, Dortmund 1, Germany

    H. M. Bolt

Authors
  1. H. M. Bolt
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Editor information

Editors and Affiliations

  1. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Ulrich Mohr Dr. med. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  2. University of British Columbia, 4891 College Highroad, Vancouver, BC, V6T 1G6, Canada

    David V. Bates M.D., F.R.C.P., F.R.C.P.C, F.A.C.P., F.R.S.C.

  3. Department of Veterinary Pathology, University of California, Davis, CA, 95616, USA

    Donald L. Dungworth Ph.D., M.R.C.V.S

  4. P. N. Lee Statistics and Computing Ltd., Hamilton House, 17 Cedar Road, Sutton, Surrey, SM2 5DA, UK

    Peter N. Lee M.A.

  5. Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, NC, 27709, USA

    Roger O. McClellan D.V.M.

  6. 19 Marryat Road, Wimbledon Common, London, SW19 5BB, UK

    Francis J. C. Roe D.M., D.Sc., F.R.C.Path. (Consultant in Toxicology) (Consultant in Toxicology)

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© 1989 Springer-Verlag Berlin Heidelberg

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Bolt, H.M. (1989). Identification of the Effective Dose of Inhaled Toxicants: General and Specific Problems. In: Mohr, U., Bates, D.V., Dungworth, D.L., Lee, P.N., McClellan, R.O., Roe, F.J.C. (eds) Assessment of Inhalation Hazards. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74606-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-74606-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74608-6

  • Online ISBN: 978-3-642-74606-2

  • eBook Packages: Springer Book Archive

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