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Structure-Activity Relationship in Biomembranes Investigated by Infrared-ATR Spectroscopy

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Biologically Active Molecules

Abstract

Infrared attenuated total reflection (IR-ATR) spectroscopy is shown to be a sensitive tool to get structural information in aqueous environment on a molecular level. The technique is optimum if the sample is immobilized in an oriented way. In this paper we report on the formation of lipid bilayer membranes which are then used for interaction studies with local anesthetics and as a support for the oriented adsorption of membrane fragments with incorporated Na,K-ATPase (Na,K-pump).

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Author information

Authors and Affiliations

  1. Institute for Physical Chemistry, University of Vienna, Währingerstrasse 42, A-1090, Vienna, Austria

    U. P. Fringeli

  2. Swiss Federal Institute of Technology, ETH-Zentrum, CH-8092, Zurich, Switzerland

    U. P. Fringeli

Authors
  1. U. P. Fringeli
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Editor information

Editors and Affiliations

  1. Department of Organic Chemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland

    Urs Peter Schlunegger

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© 1989 Springer-Verlag Berlin Heidelberg

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Fringeli, U.P. (1989). Structure-Activity Relationship in Biomembranes Investigated by Infrared-ATR Spectroscopy. In: Schlunegger, U.P. (eds) Biologically Active Molecules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74582-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-74582-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74584-3

  • Online ISBN: 978-3-642-74582-9

  • eBook Packages: Springer Book Archive

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