Abstract
Uncertainties exist regarding the relationships between sites that interact with putative probes for nicotinic acetylcholine receptors (nAChR) and physiologically functional, neuronal nAChR, as attested by the theme of this workshop. In an effort to help clarify these relationships, we have conducted experiments comparing the ligand binding properties of nAChR from the electroplax of Torpedo californica and rat muscle and putative nAChR from rat brain and from two model neuronal cell lines, PC12 and TE671. The PC12 and TE671 cell lines also have been subjected to functional studies of the cellular ensemble of nAChR by the use of ion flux techniques. Other lines of investigation in our laboratory concern the cellular and molecular mechanisms of regulation of nAChR expression by PC12 and TE671 cells.
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Lukas, R.J. (1988). Evidence for Functional and Structural Diversity of Nicotinic Acetylcholine Receptors. In: Clementi, F., Gotti, C., Sher, E. (eds) Nicotinic Acetylcholine Receptors in the Nervous System. NATO ASI Series, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74167-8_5
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DOI: https://doi.org/10.1007/978-3-642-74167-8_5
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