Abstract
Skin sensations are of three main types. First, there are sensations caused by innocuous mechanical stimuli, such as touch, pressure, vibration and tickle. Second, there are sensations of warmth and cold due to small, innocuous, temperature changes. Third, unpleasant sensations of pain or itch are caused by the presence of certain chemical agents in the skin or, in the case of pain, by potentially or actually damaging levels of thermal or mechanical stimuli. In addition, more complex sensory blends, such as wetness, also occur.
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References
Armstrong D, Dry RML, Keele CA, Markham JW (1951) Method for studying chemical excitants of cutaneous pain in man. J Physiol (Lond) 115:59–61P
Arthur RP, Shelley WB (1959) The peripheral mechanism of itch in man. In: Wostenholme G, O’Connor M (eds) Ciba Foundation Study Group No 1. Livingstone, London, pp 84–95
Beck PW, Handwerker HO, Zimmermann M (1974) Nervous outflow from the cat’s foot pad during noxious radiant heat stimulation. Brain Res 67:373–386
Beecher HK (1959) Measurement of subjective responses. Quantitative effects of drugs. Oxford University Press, New York
Bernstein JE, Swift RM, Soltani K, Lorincz AL (1982) Antipruritic effect of an opiate antagonist naloxone hydrochloride. J Invest Dermatol 78:82–83
Bing HI, Skouby AP (1950) Sensitization of cold receptors by substances with acetylcholine effect. Acta Physiol Scand 21:286–302
Bisgaard H, Kristensen J, Sondergaard J (1982) The effect of leucotriene C4 and D4 on cutaneous blood flow in humans. Prostaglandins 23:797–801
Blough D, Blough P (1977) Animal psychophysics. In: Konig WK, Staddon JER (eds) Handbook of operant behaviour. Prentice Hall, Englewood Cliffs, pp 514–539
Broadbent JL (1953) Observations on itching produced by cowhage and on the part played by histamine as a mediator of the itch sensation. Br J Pharmacol 8:263–270
Broadbent JL (1955) Observations on histamine-induced pruritis and pain. Br J Pharmacol 10:183–185
Buchsbaum MS, Davis GC, Bunney WE (1977) Naloxone alters pain perception and somatosensory evoked potentials in normal subjects. Nature 270:620–622
Byrne J (1975) A feedback controlled stimulator that delivers controlled displacements or forces to cutaneous mechanoreceptors. IEEE Trans Biomed Eng 22:66–69
Carpenter SE, Lynn B (1981) Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin. Br J Pharmacol 73:755–758
Chahl IA, Kirk EJ (1975) Toxins which produce pain. Pain 1: 3–49
Chapman WP, Jones CM (1944) Variations in cutaneous and visceral pain sensitivity in normal subjects. J Clin Invest 23:81–91
Clark WC (1969) Sensory-decision theory analysis of the placebo effect on the criterion for pain and thermal sensitivity (d’). J Abnormal Psychol 74:363–371
Clark WC, Yang JC (1974) Acupunctural analgesia? Evaluation by signal detection theory. Science 184:1096–1098
Cormia FE, Dougherty JW (1960) Proteolytic activity in development of pain and itching. Cutaneous reactions to Bradykinin and kallikrein. J Invest Dermatol 35:21–26
Cormia FE, Kuykendall U (1954) Experimental histamine pruritis. III. Influence of drugs on itch threshold. Arch Dermatol 69:206–218
Cragg BG, Downer J de C (1967) Behavioural evidence for cortical involvement in manual temperature discrimination in the monkey. Exp Neurol 19:433–442
Daly BM, Shuster S (1986) Effect of aspirin on pruritus. Br Med J 293:907
D’Amato MR (1970) Experimental psychology. Methodology, psychophysics and learning. McGraw-Hill, New York
D’Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol 72:74–79
Darian-Smith I, Johnson KO (1977) Temperature sense in the primate. Br Med Bull 33:143–148
Dehen H, Willer JC, Prier S, Boureau F, Cambier J (1978) Congenital insensitivity to pain and the “morphine-like” analgesic system. Pain 5:351–358
Dubner R, Beitel RE (1976) Neural correlates of escape behaviour in rhesus monkey to noxious heat applied to the face. In: Bonica JJ, Albe-Fessard D (eds) Advances in pain research and therapy, vol 1. Raven, New York, pp 155–160
Dyck PJ, Curtis DJ, Busher W, Offord K (1974) Description of “Minnesota thermal discs” and normal values of cutaneous thermal discrimination in man. Neurology (Minneap) 24:325–330
Dyck PJ, Karnes J, O’Brien PC, Zimmermann IR (1984) Detection thresholds of cutaneous sensation in humans. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral Neuropathy, 2nd edn. Saunders, Philadelphia, pp 1103–1138
El-Sobky A, Dostrovsky JO, Wall PD (1976) Lack of effect of naloxone on pain perception in humans. Nature 263:783–784
Emmelin N, Feldburg W (1947) The mechanism of the sting of the common nettle (Urtica mens). J Physiol (Lond) 106:440–455
Feather BW, Chapman CR, Fisher SB (1972) The effect of a placebo on the perception of painful radiant heat stimuli. Psychosom Med 34:290–294
Ferreira SH (1972) Prostaglandins, aspirin-like drugs and analgesia. Nature [New Biol] 240:200–203
Ferreira SH (1979) Prostaglandins. In: Houck JC (ed) Chemical messengers of the inflammatory process. Elsevier, Amsterdam, pp 113–151, Handbook of inflammation, vol 1
Ferreira SH (1980) Peripheral analgesia: mechanism of the analgesic action of aspirin like drugs and opiate antagonists. Br J Clin Pharmacol 10:237S–245S
Fields HL, Basbaum AI (1978) Brainstem control of spinal pain transmission. Annu Rev Physiol 40:217–248
Fitzgerald M, Lynn B (1977) The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating. J Physiol (Lond) 265:549–563
Fox RH, Hilton SM (1958) Bradykinin formation in human skin as a factor in heat vasodilatation. J Physiol (Lond) 142:219–232
Franzen O (1969) The dependence of vibrotactile threshold and magnitude functions on stimulation frequency and signal level. Scand J Psychol 10:289–298
Fredrickson RCA, Burgis V, Edwards JD (1977) Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli. Science 198:756–758
Gammon GD, Starr I (1941) Studies on the relief of pain by counterirritation. J Clin Invest 20:13–20
Gatti H, Dodge R (1929) Über die Unterschiedsempfindlichkeit bei der Reizung eines einzelnen isolierten Tastorgans. Arch Gesamte Psychol 69:405–426
Gray WD, Osterberg AC, Scuto TJ (1970) Measurement of the analgesic efficacy and potency of pentazocine by the D’Amour and Smith method. J Pharmacol Exp Ther 173:154–162
Greaves MW, McDonald-Gibson W (1973) Itch: role of prostaglandins. Br Med J 3:608–609
Greaves MW, Shuster S (1967) Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine. J Physiol (Lond) 193:255–267
Green AF, Young PA (1951) A comparison of heat and pressure analgesiometric methods in rats. Br J Pharmacol 6:572–587
Green DM, Swets JA (1966) Signal detection theory and psychophysics. Wiley, New York
Guillemin V, Benjamin F, Cornbleet T, Grossman MI (1952) A method of quantitative heat application to small skin areas at controlled temperature. J Appl Physiol 4:920–924
Hagermark O, Hokfelt T, Pernow B (1978) Flare and itch induced by substance P in human skin. J Invest Dermatol 71:233–235
Hallin RG, Torebjork HE (1976) Studies on cutaneous A and C fibre afferents, skin nerve blocks and perception. In: Zotterman Y (ed) Sensory functions of the skin in primates. Pergamon, Oxford, pp 137–148
Hardy JD, Oppel TW (1938) Studies in temperature sensation. IV. The stimulation of cold sensation by radiation. J Clin Invest 17:771–778
Hardy JD, Wolff HG, Goodell H (1952) Pain sensations and reactions. Williams and Wilkins, Baltimore
Harrington T, Merzenich MM (1970) Neural coding in the sense of touch: human sensations of skin indentation compared with the responses of slowly adapting mechanoreceptive afferents innervating the hairy skin of monkeys. Exp Brain Res 10:251–264
Hilder R, Ramey E, Darian-Smith I, Johnson KO, Dally LJ (1974) A contact stimulator for the study of cutaneous thermal sensibility. J Appl Physiol 37:252–255
Hume CW (1962) Avoidance of pain in the laboratory. In: Keele CA, Smith R (eds) The assessment of pain in man and animals. UFAW, London, pp 309–314
Hurley HJ, Koelle GB (1958) The effect of inhibition of non-specific Cholinesterase on perception of tactile sensation in the human volar skin. J Invest Dermatol 31:243–245
Huskisson EC (1974) Measurement of pain. Lancet 2:1127–1131
Jaffe JH, Martin WR (1980) Opioid analgesics and antagonists. In: Gilman AG, Goodman LG, Gilman A (eds) The pharmacological basis of therapeutics, 6th edn. McMillan, New York, pp 494–534
Jamal GA, Hansen S, Weir AI, Ballantyne JP (1985) An improved, automated method for the measurement of thermal thresholds. I. Normal subjects. J Neurol Neurosurg Psychiatry 48:354–360
Jancso G, Kiraly E, Jancso-Gabor A (1980) Direct evidence for an axonal site of action of capsaicin. Naunyn-Schmiedeberg’s Arch Pharmacol 313:91–94
Jancso G, Ferencsik M, Such G, Kiraly E, Nagy A, Bujdoso M (1985) Morphological effects of capsaicin and its analogues in newborn and adult mammals. In: Hakanson R, Sundler F (eds) Tachykinin antagonists. Elsevier, Amsterdam, pp 35–44
Jancso N (1960) Role of the nerve terminals in the mechanism of inflammatory rections. Bull Millard Fillimore Hosp 7:53–77
Jancso N (1968) Desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. In: Lim RKS, Armstrong D, Pardo EG (eds) Pharmacology of pain. Pergamon, Oxford, pp 35–55 (Proceedings of the international pharmacology meeting, vol 9)
Janssen PAJ, Niemigeers CJE, Dony JGH (1963) The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawal reflex in rats. Arzneimittelforschung 13:502–507
Keele CA (1970) Chemical causes of itch and pain. Annu Rev Med 21:67–74
Keele CA, Armstrong D (1964) Substances producing itch and pain. Arnold, London
Kenshalo DR (1978) Biophysics and psychophysics of feeling. In: Carterette EC, Friedman MP (eds) Handbook of perception, vol 6B. Academic, New York, pp 29–74
Kenshalo DR, Bergen DC (1975) A device to measure cutaneous temperature sensitivity in humans and subhuman species. J Appl Physiol 39:1038–1040
Kenshalo DR, Nafe JP, Dawson WW (1960) A new method for the investigation of thermal sensitivity. J Psychol 49:29–41
Kiistala U (1968) Suction blister device for separation of viable epidermis from dermis. J Invest Dermatol 50:129–137
Kling JW, Riggs LA (1971) Experimental psychology. Holt Rinehart and Winston, New York
Krause LB, Shuster S (1983) The mechanism of action of antipruritic drugs. Br Med J 287:1199–1200
LaMotte RH, Campbell JN (1978) Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgements of thermal pain. J Neurophysiol 41:509–528
LaMotte RH, Mountcastle VB (1975) Capacities of humans and monkeys to discriminate between vibratory stimuli of different frequency and amplitude: a correlation between neural events and psychophysical measurements. J Neurophysiol 38:539–559
Lembeck F (1957) Untersuchungen über die Auslösung afferenter Impulse. Arch Exp Pathol Pharmakol 230:1–9
Lembeck F, Gamse R (1977) Lack of effect of substance P on paravascular pain receptors. Naunyn-Schmiedeberg’s Arch Pharmacol 299:295–303
Levine JD, Gordon ND, Fields HL (1978) The mechanism of placebo analgesia. Lancet 2:654–657
Lewis T (1935) Experiments relating to cutaneous hyperalgesia and its spread through somatic nerves. Clin Sci 2:373–423
Lindahl O (1961) Experimental skin pain induced by injection of water soluble substances in human. Acta Physiol Scand 51:Suppl 179
Loh L, Nathan PW (1978) Painful peripheral states and sympathetic blocks. J Neurol Neurosurg Psychiatry 41:664–671
Lynn B (1977 a) A mechanical stimulator for applying graded forces to the skin. J Physiol (Lond) 269:7–8P
Lynn B (1977 b) Cutaneous hyperalgesia. Br Med Bull 33:103–108
Lynn B (1980) Heat pain sensitivity of human skin after mild heat injury and its lack of dependence on the local blood flow. Pain 8:189–196
Lynn B (1983) Cutaneous sensation. In: Goldsmith L (ed) Biochemistry and physiology of the skin. Oxford University Press, New York, pp 654–684
Lynn B, Perl ER (1977) A comparison of four tests for assessing the pain sensitivity of different subjects and test areas. Pain 3:353–365
Lynn B, Pini A (1985) Long-term block of afferent C-fibres following capsaicin treatment in the rat. J Physiol (Lond) 362:115–124
Lynn B, Pini A, Baranowski R (1987) Injury of somatosensory afferents by capsaicin: selectivity and failure to regenerate. In: Pubols LM, Sessle BJ (eds) Effects of injury on trigeminal and spinal somatosensory systems. Liss, New York, pp 115–124
Mackenzie RA, Burke D, Skuse NF, Lethlean AK (1975) Fibre function and perception during cutaneous nerve block. J Neurol Neurosurg Psychiatry 38:865–873
Maier SF, Davies S, Grau JW, Jackson RL, Morrison DH, Moye T (1980) Opiate antagonists and long-term analgesic reaction induced by inescapable foot shock in rats. J Comp Physiol Psychol 94:1172–1183
Marsland AR, Weekes JWN, Atkinson RL, Leong MG (1982) Phantom limb pain: a case for beta blockers? Pain 12:295–297
Melton FM, Shelley WB (1950) The effect of topical antipruritic therapy on experimentally induced pruritis in man. J Invest Dermatol 15:325–332
Merksey H, Spear FG (1964) The reliability of the pressure algometer. Br J Soc Clin Psychol 3:130–136
Meyer RA, Walker RE, Mountcastle VB (1976) A laser stimulator for the study of cutaneous thermal and pain sensations. IEEE Trans Biomed Eng 23:54–60
Moulton R, Spector WG, Willoughby DA (1957) Histamine release and pain production by xanthosine and related compounds. Br J Pharmacol 12:365–370
Mountcastle VB (1980) Medical physiology. Mosby, St Louis
Mountcastle VB, LaMotte RH, Carli G (1972) Detection thresholds for vibratory stimuli in humans and monkeys: a comparison with threshold events in mechanoreceptive afferent nerve fibres innervating the monkey hand. J Neurophysiol 35:122–136
Mullin FJ, Luckhardt AB (1935) Effects of certain analgesic drugs on cutaneous, tactile and pain sensitivity. Am J Physiol 113:100–101
Parkhouse J, Pleuvry BJ, Rees JMH (1979) Analgesic drugs. Blackwell, Oxford
Pert A (1982) Mechanisms of opiate analgesia and the role of endorphins in pain suppression. Adv Neurol 33:107–122
Petit J, Galifret Y (1978) Sensory coupling function and the mechanical properties of the skin. In: Gordon G (ed) Active touch. Pergamon, Oxford, pp 19–27
Pini A (1983) Effects of capsaicin on conduction in a cutaneous nerve of the rat. J Physiol (Lond) 338:60–61P
Poulton EC (1968) The new psychophysics: six models for magnitude estimation. Psychol Bull 69:1–19
Randall LD, Selitto JJ (1957) A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn 61:409–419
Ritchie JM, Greene NM (1980) Local anesthetics. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 6th edn. Macmillan, New York, pp 300–320
Robertson I, Greaves MW (1978) Responses of human skin blood vessels to synthetic histamine analogues. Br J Clin Pharmacol 5:319–322
Robinson JE, Short RV (1977) Changes in breast sensitivity at puberty, during the menstrual cycle, and at parturition. Br Med J 1:1188–1191
Ruch T, Patton HD (1979) The brain and neural function. Saunders, Philadelphia (Physiology and biophysics, vol 1)
Scadding JW, Wall PD, Wynn Parry CB, Brooks DM (1982) Clinical trial of propranolol in post-traumatic neuralgia. Pain 14:283–292
Schweizer A, Brom R, Glatt M, Bray MA (1984) Leukotrienes reduce nociceptive responses to bradykinin. Eur J Pharmacol 105:105–112
Shelley WB, Arthur RP (1957) The neurohistology and neurophysiology of the itch sensation in man. Arch Dermatol 76:296–323
Shuster S (1981) Reason and the rash. Proc R Inst GB 53:136–163
Sicuteri F, Franchi G, Fanciulacci M, del Bianco PL (1965) Serotonin bradykinin potentiation of pain receptors in man. Life Sci 4:309–316
Sinclair D (1981) Mechanisms of cutaneous sensation. Oxford University Press, Oxford
Skouby AP (1951) Sensitization of pain receptors by cholinergic substances. Acta Physiol Scand 24:174–191
Skouby AP (1953) The influence of acetylcholine, curarine and related substances on the threshold for chemical pain stimuli. Acta Physiol Scand 29:340–352
Smith GM, Beecher HK (1969) Experimental production of pain in man: sensitivity of a new method to 600 mg aspirin. Clin Pharmacol Ther 10:213–216
Stevens JC, Stevens SS (1960) Warmth and cold: dynamics of sensory intensity. J Exp Psychol 60:183–192
Stevens SS (1957) On the psychophysical law. Psychol Rev 64:153–181
Stevens SS (1959) Tactile vibration: dynamics of sensory intensity. J Exp Psychol 57:210–218
Stevens SS (1970) Neural events and the psychophysical law. Science 170:1043–1050
Stewart JM, Getto CJ, Neldner K, Reeve EB, Kirvoy WA, Zimmermann E (1976) Substance P and analgesia. Nature 262:784–785
Stoll AM, Hardy JD (1950) Study of thermocouples as skin thermometers. J Appl Physiol 2:531–543
Szolcsanyi J (1977) A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J Physiol (Paris) 73:251–259
Talbot WH, Darian-Smith I, Kornhuber HH, Mountcastle VB (1968) The sense of flutter vibration: comparison of the human capacity with response patterns of mechanoreceptive afferents from the monkey hand. J Neurophysiol 31:301–334
Tapper DW (1970) Behavioural evaluation of the tactile pad receptor system in hairy skin of the cat. Exp Neurol 26:447–459
Torebjork HE, Hallin RG (1973) Perceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nerves. Exp Brain Res 16:321–332
Toth-Kasa I, Jancso G, Bognar A, Husz S, Obal F (1986) Capsaicin prevents histamineinduced itching. Int J Clin Pharmacol Res 6:163–169
Verillo RT, Capraro AJ (1975) Effect of stimulus frequency on subjective vibrotactile magnitude ratings. Percept Psychophys 17:91–96
Vierck CJ (1973) Alterations of spatio-tactile discrimination after lesions of primate spinal cord. Brain Res 58:69–79
Vierck CJ (1974) Tactile movement detection and discrimination following dorsal column lesions in monkeys. Exp Brain Res 20:331–346
Von Frey M, Kiesow F (1899) Ueber die Function der Tastkoerperchen. Z Psychol Physiol Sinnesorgane 20:126–163
Wall PD (1970) The sensory and motor role of impulses travelling in the dorsal columns towards cerebral cortex. Brain 93:505–524
Wall PD, Gutnick M (1974) Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma. Exp Neurol 43:580–593
Wallin G, Torebjork E, Hallin R (1976) Preliminary observations on the pathophysiology of hyperalgesia in the causalgic pain syndrome. In: Zotterman Y (ed) Sensory functions of the skin in primates. Pergamon, Oxford, pp 489–499
Weber EH (1978) The sense of touch. Academic, London
Weinstein S (1977) Effects of local anaesthetics on tactile sensitivity thresholds for cutaneous and mucous membranes. J Invest Dermatol 69:136–145
Werner G, Mountcastle VB (1965) Neural activity in mechanoreceptive cutaneous afferents: stimulus-response relations, Weber functions and information transmission. J Neurophysiol 28:359–397
Westerman R, Magerl W, Handwerker H, Szolcsanyi J, Pratt A (1986) Itch sensation evoked by percutaneous histamine iontophoresis and cowhage spicules applied to human skin. Proc Int Union Physiol Sci 16:571
Westling G, Johansson R, Vallbo AB (1976) A method for mechanical stimulation of skin receptors. In: Zotterman Y (ed) Sensory functions of the skin in primates. Pergamon, Oxford, pp 151–158
Wikler A, Goodell H, Wolff HG (1945) Studies on pain. The effect of analgesic agents on sensations other than pain. J Pharmacol Exp Ther 83:294–299
Willer JC, Boureau F, Berny J (1979) Nociceptive flexion reflexes elicited by noxious laser radiant heat in man. Pain 7:15–20
Willer JC, Dehen H, Cambier J (1981) Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes. Science 212:689–691
Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York
Woolf CJ (1983) Evidence for a central component of post-injury pain hypersensitivity. Nature 306:686–688
Yaksh TL (1981) Spinal opiate analgesia: characteristics and principles of action. Pain 11:293–346
Yaksh TL, Reddy SVR (1981) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology 54:451–467
Zotterman Y (1959) Thermal sensations. In: Field J, Magoun HW (eds) Neurophysiology, vol 1. American Physiological Society, Washington, pp 431–458 (Handbook of physiology, sect 1)
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Lynn, B. (1989). Measurement of Drug Action in the Skin: Sensation. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_6
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