Pharmacology of the Skin II

Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases

  • Malcolm W. Greaves
  • Sam Shuster

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 2)

Table of contents

  1. Front Matter
    Pages I-XXXVII
  2. Methods

    1. Front Matter
      Pages 1-1
    2. R. P. R. Dawber, N. B. Simpson
      Pages 27-31
    3. S. Shuster
      Pages 51-54
    4. B. Nusgens, C. M. Lapière
      Pages 63-76
    5. K. T. Holland
      Pages 77-79
    6. M. Corbett, A. Herxheimer
      Pages 81-90
  3. Absorption, Metabolism and Toxicity

    1. Front Matter
      Pages 91-91
    2. J. E. Shaw, S. K. Chandrasekaran
      Pages 115-122
    3. H. Kappus
      Pages 123-163
    4. F. Marks
      Pages 165-194
    5. J. D. Middleton
      Pages 195-207
    6. J. R. Gibson
      Pages 209-224

About this book


The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un­ resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.


absorption drug metabolism pharmacology physiology research toxicology

Editors and affiliations

  • Malcolm W. Greaves
    • 1
  • Sam Shuster
    • 2
  1. 1.The Institute of DermatologySt. Thomas’s HospitalLondonGreat Britain
  2. 2.Department of Dermatology, The Royal Victoria InfirmaryThe University of Newcastle upon TyneNewcastle upon TyneGreat Britain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74056-5
  • Online ISBN 978-3-642-74054-1
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book