Abstract
Virology is a rapidly advancing science which is now beginning to pay clear dividends in terms of our understanding of the relationship betwen viruses and their host cells and in providing more rational ways of developing major therapeutic advances. Since the first viruses to be readily tackled by chemotherapy are members of the Herpesviridae this chapter will confine itself to a discussion of the biology of this fascinating group and our attempts at the therapeutic control of the human diseases these cause.
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References
Balfour HH, Bean B, Laskin OL, Ambinder RF, Meyers JD, Wade JC, Zaia JA et al. (1983) Acyclovir halts progression of herpes zoster in immunocompromised patients. N Engl J Med 308:1448–1453
Bean B, Braun C, Balfour HH (1982) Acyclovir therapy for acute herpes zoster. Lancet 2:118–121
Blyth WA, Habour DA, Hill TJ (1980) Effect of acyclovir on recurrence of hepres simplex skin lesions sin mice. J Gen Virol 48:417–419
Brigden D, Fowle A, Rosling A (1980) Acyclovir, a new antiherpetic drug: early experience in man with systemically administered drug. In: Collier LH (ed) Developments in antiviral therapy. Academic, Oxford, pp 53–62
Brigden D, Bye A, Fowle ASE, Rogers H (1981 a) Human pharmacokinetics of acyclovir (an antiviral agent) following rapid intravenous injection. J Antimicrob Chemother 7:399–404
Brigden D, Fiddian P, Rosling AE, Ravenscroft T (1981 b) Acyclovir — a review of the preclinical and early clinical data of a new antiherpes drug. Antiviral Res 1:203–212
Bryson Y, Dillon M, Lovett M, Acuna G, Taylor S, Cherry J, Johnson L et al. (1983) Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. N Engl J Med 308:916–921
Burns WH, Sarai R, Santos GW, Laskin OL, Leitman PS, McLaren C, Barry DW (1982) Isolation and characterisation of resistant herpes simplex virus after acyclovir therapy. Lancet 1:421–423
Cook ML, Stevens JG (1973) Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence of intra-axonal transport of infection. Infect Immun 7:272–288
Corey L, Nahmias AJ, Guinan ME, Benedetti J, Critchlow C, Holmes KK (1982) A trial of topical acyclovir in genital herpes simplex virus infections. N Engl J Med 306:1313 – 1319
Corey L, Fife KH, Benedetti K, Winter CA, Fahnlander A, Connor JD, Hintz MA, Holmes KK (1983) Intravenous acyclovir for the treatment of primary genital herpes. Ann Intern Med 98:914–921
Crumpacker CS, Schnipper LE, Marlowe SI, Kowalsky PN, Hershey BJ, Levin MJ (1982) Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir. N Engl J Med 306:343–346
De Clercq E, Degreef H, Wildiers J, de Jonge G, Drochmans A, Deschamps J, de Somer P (1980) Oral (E)-5-(2-bromovinyl)-2-deoxyuridine in severe herpes zoster. Br Med J 281:1178
Dekker C, Ellis MN, McLaren C, Hunter G, Rogers J, Barry DW (1983) Virus resistance in clinical practice. J Antimicrob Chemother 12B:137–152
De Miranda P, Whitley RJ, Blum MR, Keeney RE, Barton N, Cochetto DM, Good S et al. (1979) Acyclovir kinetics after intravenous infusion. Clin Pharmacol Ther 26:718–728
Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ (1977) Selectivity of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci USA 74:5716–5720
Fiddian AP, Yeo JM, Stubbings R, Dean D (1983) Successful treatment of herpes labialis with topical acyclovir. Br Med J 286:1699–1701
Field HJ, Darby G (1980) Pathogenicity in mice of strains of herpes simplex virus which are resistant in vitro and in vivo. Antimicrob Agents Chemother 17:209–216
Field HJ, Bell SE, Elion GB, Nash AA, Wildy P (1979) Effects of acycloguanosine treatment on acute and latent herpes simplex infections in mice. Antimicrob Agents Chemother 15:554–561
Field HJ, Darby G, Wildy P (1980) Isolation and characterisation of acyclovir resistant mutants of herpes simplex virus. J Gen Virol 49:115–124
Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB (1979) Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl) guanine and its triphosphate. J Virol 32:72–77
Gluckman E, Lotsberg J, Devargie A, Zhao A, Zhao XM, Melo R, Gomez-Morales M, Nebout T et al. (1983) Prohylaxis of herpes infections after bone marrow transplantation by oral acyclovir. Lancet 2:706–708
Hann IM, Prentice HG, Blacklock HA, Ross MGR, Brigden D, Rosling AE, Burke C et al. (1983) Acyclovir prophylaxis against herpes virus infections in severely immunocompromised patients: randomised double blind trial. Br Med J 287:384–388
Heidelburger C, King DH (1979) Trifluorothymidine. Pharmacol Ther 6:427–442
Jones BR, Coster DJ, Fison PN, Thompson GM, Cobo LM, Falcon MG (1979) Efficacy of acycloguanosine against herpes simplex corneal ulcers. Lancet 1:243–244
Juel-Jensen BE, MacCullum FO (1972) Herpes simplex, varicella and zoster. Heinemann, London
Kaufman HE, Martola EL, Dohlamnm CH (1962) Use of 5-iodo-2’-deoxyuridine (IDU) in treatment of herpes simplex keratitis. Arch Ophthalmol 68:235–239
Kinghorn GR, Barton IG, Potter CW, Fiddian AP (1983) Oral acyclovir prophylaxis of recurrent genital herpes (Abstr 185). 5th International Meeting of the International Society for STD Research, Seattle
Klein RJ, Freidman-Kein AE, de Stefano E (1979) Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine. Antimicrob Agents Chemother 15:723–729
McGill J, MacDonald DR, Fall C, McKendrick GDW, Copplestone A (1983) Intravenous acyclovir in acute herpes zoster infection. J Infect 6:157–161
McKendrick MW, McGill JI, Bell AM, Hickmott E, Burke C (1984) Oral acyclovir for herpes zoster. Lancet 2:925
Merigan TC, Rand KH, Pollard RB, Abdallah PS, Jordon GW, Fried RP (1978) Human leukocyte interferon for the treatment of herpes zoster patients with cancer. N Engl J Med 298:981–987
Meyers JD, Wade JC, Mitchell CD, Aral R, Leitman PS, Durak DT, Levin MJ et al. (1982) Multicentre collaborative trial of intravenous acyclovir for the treatment of mucocutaneous HSV infection in the compromised host. Am J Med 73(1A):229–235
Mindel A, Adler MW, Sutherland S, Fiddian AP (1982) Intravenous acyclovir treatment for primary genital herpes. Lancet 1:697–700
Mindel A, Weiler IVD, Faherty A, Sutherland S, Hindlay D, Fiddian AP, Adler MW (1984) Prophylactic oral acyclovir in recurrent genital herpes. Lancet 2:57–59
Mitchell CD, Bean B, Gentry SR, Groth KE, Boen JR, Balfour HH (1981) Acyclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients. Lancet 1:1389–1392
Nilsen AE, Aasen T, Halsos AM, Kinge BR, Tjøtta EAL, Wikström K, Fiddian AP (1982) Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes. Lancet 2:571–573
Pavan-Langston D, Dohlman CH (1972) A double blind clinical study of adenine arabino-side therapy of viral keratoconjunctivitis. Am J Ophthalmol 74:81–88
Peterslund NA, Seyer-Hansen K, Ipsen J, Esmann V, Schonheyder H, Juhl H (1981) Acyclovir in herpes zoster. Lancet 2:827–830
Prentice HG (1983) Use of acyclovir for prophylaxis of herpes infections in severely immunocompromised patients. J Antimicrob Chemother 12B: 153–159
Reichman RC, Badger GJ, Mertz GJ, Corey L, Richmann DD, Connor JD, Redfield D et al. (1984) Treatment of recurrent genital herpes simplex infection with oral acyclovir: a controlled trial. JAMA 251:2103–2107
Sarai R, Burns WH, Laskin OL, Santos GW, Leitmann PS (1981) Acyclovir prophylaxis of herpes simplex virus infections, a randomised double-blind, controlled trial in bone marrow transplant recipients. N Engl J Med 305:63–67
Skoldenberg B, Forsgren M, Alestig K, Bergstrom T, Burman L, Dahlquist E, Forkman A et al. (1984) Acyclovir versus vidarabine in herpes simplex encephalitis. Lancet 2:707–711
Straus SE; Takiff HE, Seidlin M, Bachrach S, Lininger L, di Giovanna JJ, Western KA et al. (1984) Suppression of frequently recurring genital herpes: a placebo-controlled double-blind trial of oral acyclovir. J Med 310:1545–1550
Wade JC, Newton B, Flournoy N, Meyers JD (1984) Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplant. Ann Intern Med 100:823–828
Wellings PC, Audry PN, Borz FH, Jones BR, Brown DC, Kaufman HE (1972) Clinical evaluaton of trifluorothymidine in the treatment of herpes simplex corneal ulcers. Am J Ophthalmol 73:932–942
Whitley RJ, Alford CA (1981) Parenteral antiviral chemotherapy of human herpesviruses. In: Nahmias AJ, Dowdle WR, Shinazi RF (eds) The human herpesviruses. Elsevier, New York, pp 478–490
Whitley RJ, Chien LT, Dolin R, Galasso GJ, Alford C (1976) Adenine arabinoside therapy of herpes zoster in the immunosuppressed NIAID collaborative antiviral study. N Engl J Med 294:1193–1199
Whitley RJ, Soong S, Dolin R, Galasso GJ, Chien LT, Alford C (1978) Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. N Engl J Med 297:289–294
Whitley R, Alford C, Hess F, Buchanan R (1980) Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs 20:267–282
Whitley RJ, Soong S, Kirsch MS, Karchmer AW, Dolin R, Galasso G, Dunnick J, Alford CA (1981) Herpes simplex encephalitis. Vidarabine therapy and diagnostic problems. N Engl J Med 304:313–318
Wildenhoff KE, Ipsen J, Esmann V, Ingemann-Fensen J, Hjelm Poulsen J (1979) Treatment of herpes zoster with idoxuridine ointment, including a multivariate analysis of symptoms and signs. Scand J Infect Dis 11:1–9
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Brigden, D. (1989). Herpes Virus Infections. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_30
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DOI: https://doi.org/10.1007/978-3-642-74054-1_30
Publisher Name: Springer, Berlin, Heidelberg
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