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Calcium Channels and the Heart

  • Conference paper
The Calcium Channel: Structure, Function and Implications

Part of the book series: Bayer AG Centenary Symposium ((BAYER))

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Abstract

Calcium ions play a key role in muscle contraction. In the resting state the cytosolic Ca2+ is maintained at a concentration of around 10-7 M, but upon excitation this level increases by a factor of 100 or more. In cardiac muscle this increase involves an influx of Ca2+ through the voltage-sensitive Ca2+ -selective channels which traverse the sarcolemma and a secondary release of intracellularily stored Ca2+ (Fabiato and Fabiato 1979). The structure, biochemistry, ionic selectivity and voltage regulation of these trans-sarcolemmal channels have been the subject of previous papers in this symposium, as has their isolation and reconstitution.

These investigations were supported by the National Health and Medical Research Council, and the National Heart Foundation of Australia.

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Author information

Authors and Affiliations

  1. Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, 3084, Australia

    J. S. Dillon, X. H. Gu & W. G. Nayler

Authors
  1. J. S. Dillon
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  2. X. H. Gu
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  3. W. G. Nayler
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Pennsylvania, Philadelphia, PA, 19104-6085, USA

    Martin Morad (Professor of Physiology and Medicine) (Professor of Physiology and Medicine)

  2. Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, 3084, Victoria, Australia

    Winifred G. Nayler (Principal Research Investigator) (Principal Research Investigator)

  3. Bayer AG, Institute of Pharmacology, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    Stanislav Kazda (Associate Professor of Pharmacology and Toxicology) & Matthias Schramm (Associate Professor of Physiology) (Associate Professor of Pharmacology and Toxicology) &  (Associate Professor of Physiology)

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© 1988 Springer-Verlag Berlin Heidelberg

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Dillon, J.S., Gu, X.H., Nayler, W.G. (1988). Calcium Channels and the Heart. In: Morad, M., Nayler, W.G., Kazda, S., Schramm, M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73914-9_24

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  • DOI: https://doi.org/10.1007/978-3-642-73914-9_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50061-2

  • Online ISBN: 978-3-642-73914-9

  • eBook Packages: Springer Book Archive

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