The Calcium Channel: Structure, Function and Implications

Stresa/Italy, May 11–14, 1988

  • Martin Morad
  • Winifred G. Nayler
  • Stanislav Kazda
  • Matthias Schramm

Part of the Bayer AG Centenary Symposium book series (BAYER)

Table of contents

  1. Front Matter
    Pages I-XXVII
  2. History and Philosophy of Bayer Pharmaceutical Research

  3. The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882

  4. Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships

    1. R. H. Kretsinger, N. D. Moncrief, M. Goodman, J. Czelusniak
      Pages 16-34
  5. The Function of Calcium Channel

  6. The Structure of the Calcium Channel

    1. Front Matter
      Pages 157-157
    2. J. Barhanin, M. Fosset, M. Hosey, C. Mourre, D. Pauron, J. Qar et al.
      Pages 159-167
    3. H. Glossmann, J. Striessnig, L. Hymel, G. Zernig, H. G. Knaus, H. Schindler
      Pages 168-192
    4. A. Röhrkasten, H. E. Meyer, T. Schneider, W. Nastainczyk, M. Sieber, H. Jahn et al.
      Pages 193-199
    5. M. J. Seagar, M. Takahashi, W. A. Catterall
      Pages 200-210

About these proceedings

Introduction

This is the first book to summarize experimental results from the new, rapidly expanding field of research into the calcium channel in cell membrane. Calcium is an ubiquitous messenger of various cellular functions. Its fundamental role in the regulation of cardiac contractions has long been recognized. Drugs counteracting some actions of calcium ions, namely calcium antagonists, have since become essential to research. In the last decade it has been established that calcium ions reach their target intracellular system by passing through specialized calcium channels in the membrane. Recently improved experimental techniques combined with the discovery of highly specific Ca channel ligands have dramatically enlarged our knowledge of the molecular structure and function of such channels. The contributions by leading world specialists shed new light on both basic science and possible clinical implications for cardiovascular pharmacology, endocrinology and neuropharmacology.

Keywords

ATP Calcium biochemistry cell membrane drug endocrinology kinetics neuropharmacology pharmacology phosphorylation physiology protein receptor research toxicity

Editors and affiliations

  • Martin Morad
    • 1
  • Winifred G. Nayler
    • 2
  • Stanislav Kazda
    • 3
  • Matthias Schramm
    • 3
  1. 1.Department of PhysiologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Medicine, Austin HospitalUniversity of MelbourneHeidelbergAustralia
  3. 3.Bayer AG, Institute of PharmacologyWuppertal 1Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-73914-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-50061-2
  • Online ISBN 978-3-642-73914-9
  • Series Print ISSN 1431-116X
  • About this book