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The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Rat Kidney Cells

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Cell to Cell Signals in Mammalian Development

Part of the book series: NATO ASI Series ((ASIH,volume 26))

Summary

Using growth factors-defined and serum—free culture media, we have shown that phenotypic transformation of normal rat kidney cells does not require specific polypeptide growth factors but more generally reflects the ability of these cells to respond to multiple growth factors. Epidermal growth factor and platelet-derived growth factor contribute to this process by a direct mitogenic action on these cells, modulating agents like transforming growth factor—β and retinoic acid have an indirect growth stimulating effect. Some aspects of the mechanism whereby these modulating agents can exert their action will be discussed.

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Authors and Affiliations

  1. Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 9, 3584 CT, Utrecht, The Netherlands

    E. J. J. van Zoelen

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  1. E. J. J. van Zoelen
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Editors and Affiliations

  1. Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

    S. W. de Laat , J. G. Bluemink  & C. L. Mummery ,  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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van Zoelen, E.J.J. (1989). The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Rat Kidney Cells. In: de Laat, S.W., Bluemink, J.G., Mummery, C.L. (eds) Cell to Cell Signals in Mammalian Development. NATO ASI Series, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73142-6_22

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  • DOI: https://doi.org/10.1007/978-3-642-73142-6_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73144-0

  • Online ISBN: 978-3-642-73142-6

  • eBook Packages: Springer Book Archive

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