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Activation of the Human Epidermal Growth Factor Receptor

  • L. H. K. Defize
  • J. Boonstra
  • P. M. P. van Bergen en Henegouwen
  • A. J. Verkley
  • S. W. de Laat
Conference paper
Part of the NATO ASI Series book series (volume 26)

Abstract

Polypeptide growth factors have been recognized as important determinants In the regulation of cellular proliferation and differentiation (for a review: Sporn and Roberts, 1988). They exert their mitogenic or differentiating activity at nanomolar concentrations by binding to specific high-affinity receptor molecules localized in the plasma membrane. The ultimate biological action is dependent on the nature of the target cell. The number of identified growth factors is still rapidly growing. Several of these factors have been purified to homogeneity and their primary amino acid sequence has been determined completely or in part.

Keywords

Epidermal Growth Factor Receptor Human Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Kinase Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • L. H. K. Defize
    • 2
  • J. Boonstra
    • 1
    • 2
  • P. M. P. van Bergen en Henegouwen
    • 1
    • 2
  • A. J. Verkley
    • 1
    • 2
  • S. W. de Laat
    • 2
  1. 1.Dept. of Molecular CelbiologyUniversity of UtrechtUtrechtThe Netherlands
  2. 2.Hubrecht LaboratoryNetherlands Institute for Developmental BiologyUtrechtThe Netherlands

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