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Activation of the Human Epidermal Growth Factor Receptor

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Cell to Cell Signals in Mammalian Development

Part of the book series: NATO ASI Series ((ASIH,volume 26))

Abstract

Polypeptide growth factors have been recognized as important determinants In the regulation of cellular proliferation and differentiation (for a review: Sporn and Roberts, 1988). They exert their mitogenic or differentiating activity at nanomolar concentrations by binding to specific high-affinity receptor molecules localized in the plasma membrane. The ultimate biological action is dependent on the nature of the target cell. The number of identified growth factors is still rapidly growing. Several of these factors have been purified to homogeneity and their primary amino acid sequence has been determined completely or in part.

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Authors and Affiliations

  1. Dept. of Molecular Celbiology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    J. Boonstra, P. M. P. van Bergen en Henegouwen & A. J. Verkley

  2. Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

    L. H. K. Defize, J. Boonstra, P. M. P. van Bergen en Henegouwen, A. J. Verkley & S. W. de Laat

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  1. L. H. K. Defize
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  2. J. Boonstra
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  3. P. M. P. van Bergen en Henegouwen
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  4. A. J. Verkley
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  5. S. W. de Laat
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Editors and Affiliations

  1. Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

    S. W. de Laat , J. G. Bluemink  & C. L. Mummery ,  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Defize, L.H.K., Boonstra, J., van Bergen en Henegouwen, P.M.P., Verkley, A.J., de Laat, S.W. (1989). Activation of the Human Epidermal Growth Factor Receptor. In: de Laat, S.W., Bluemink, J.G., Mummery, C.L. (eds) Cell to Cell Signals in Mammalian Development. NATO ASI Series, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73142-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-73142-6_14

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  • Print ISBN: 978-3-642-73144-0

  • Online ISBN: 978-3-642-73142-6

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