Zusammenfassung
Mit den folgenden Ausführungen möchte ich mich bewußt auf immunologische Aspekte der Sterilität — unter der wir die Unfähigkeit der Gametenvereinigung verstehen — beschränken, während der angloamerikanisch geprägte Begriff Infertilität bei uns ja die Unfähigkeit, ein lebendes Kind zu gebären, bedeutet. Die Ätiologie von 1620 Sterilitätspatientenehepaaren, die wir in den Jahren 1980–1985 an der Universitäts-Frauenklinik in Kiel behandelten, teilte sich wie folgt auf (Abb. 1).
Preview
Unable to display preview. Download preview PDF.
Literatur
Boettcher B, Kay DJ, Rümke P, Wright LE (1971) Human sera containing immunoglobulin and non immunoglobulin spermagglutinations. Biol Reprod 5: 236–241
Boettcher B, Hjort T, Rümke P, Shulman S, Uyazou O (1977) Auto-and Iso-antibodies to antigens of the human reproductive system. Acta Pathol Microbiol Scand [Suppl] 258: 1077–1983
Bronson R, Coope G, Rosenfeld B, et al (1986) Antisperm-antibodies detected by agglutination, immobilization and spermacytotoxicity tests and by immunobead binding technique. J Reprod Immunol 8: 170–180
Czuppon AB (1984) Biochemical characterization of a human spermatozoal sialoglycoprotein with respect to antigenecity by its salic acid moities. Biochem Int 8: 9–18
Czuppon AB, Mettler L (1981) Acrosin dependent solubilization of antigenic peptides from human spermatozoa. Am J Reprod Immunol 1: 303–306
Czuppon AB, Mettler L (1987) Detection of anti-sperm antibodies in cervical mucus and seminal plasma by a simple agglutinationstest. Am J Reprod Immunol (im Druck)
Dietl J, Czuppon AB, Mettler L (1983) Characterization of procine zona pellucida antigens by immuno-affinity chromatography and high pressure liquid chromatography. Am J Reprod Immunol 4: 116–120
Fikentscher R, Semm K (1968) Die Bedeutung des Sims-Huhner-Tests in der Sterilitätspraxis. Geburtshilfe 168: 101–105
Franklin RR, Dukes CD (1964) Further studies on spermagglutinating antibody and unexplained infertility. JAMA 190: 682–685
Friberg J (1974) Clinical and immunological studies in sperm agglutinating antibodies in serum and seminal fluid. Acta Obstet Gynecol [Suppl] 36: 3–76
Gwatkin RBL (1982) Receptor for sperm on the mammalian ovum. In: Hafez ESE, Semm K (eds) In vitro fertilization and embryo-transfer. MTP, Baltimore NewYork
Hamerlynck JV (1970) Cytotoxis and other auto-antibodies against spermatozoa in realation to infertility in the human male. MD Thesis, University of Amsterdam
Hamerlynck JV, Rümke P (1968) A test for the detection of cytotoxic antibodies to spermatozoa in man. J Reprod Fertil 17: 191–194
Hjort T, Hansen J (1971) Immunofluorescent studies on human spermatozoa. I. The detection of different spermatozoal antibodies and their occurrence in normal and infertile women. Clin Exp Immunol 8: 9–23
Isojima S, Tsuzuku O (1968) Problem of ABO blood group incomatibility and sterility. The effect of blood group antibody on spermatozoa. Am J Obstet Gynecol 102: 304–306
Isojima S, Tzuchiy K, Kayama K, Tanaku K, Naka CO, Adachi H (1972) Further studies in sperm immobilizing antibodies found in sera of unexplained cases of sterility in women. Am J Obstet Gynecol 112: 199–207
Jager S, Kremer J, Hulder I (1981) The significance of the Fc part of antispermatozoal antibodies for the shaking phenomena in the sperm-cervical mucus contact test. Fertil Steril 36: 792–797
Joel CA (1942) Zur Biologie der menschlichen Samenfäden. Schweiz Med Wochenschr 72: 440–441
Kibrick S, Belding DL (1952) Methods for the detection of antibodies against mammalian spermatozoa. Fertil Steril 3: 419–429
Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497
Kremer J (1965) A simple sperm penetration test. Int Fertil 10: 209–215
Kremer J, Jager S (1976) The sperm cervical mucus contract test: a preliminary report. Fertil Steril 27: 335–340
Kremer J, Jager S (1984) Klinik der Fertilitätsstörungen des Mannes infolge Antispermatozoenantikörpem. Heiv Chir Acta 51: 321–328
Manarang-Pangan S, Behrman SJ (1971) Spermatotoxicity of immune sera in human infertility. Fertil Steril 22: 145–147
Mettler L (1977a) Immunologie der weiblichen Sterilität. Grosse, Berlin
Mettler L (1977b) Spermatozoenantigene. In: Schirren C, Semm K (Hrsg) Fortschritte der Fertilitätsforschung, Bd 4. Grosse, Berlin
Mettler L, Skrabei H (1979) Isolation of a human spermatozoal hapten II 2 2 and its reaction with naturally occuring human sperm-immobilizing sera from infertile patients. J Reprod Immunol 1: 174–183
Mettler L, Paul S, Baukloh V, Feller AC (1984) Monoclonal sperm antibodies: their potential for investigation of sperms as target of immunological contraception. Am J Reprod Immunol 5: 125–128
Mettler L, Bulatko A, Paul S, Wiegand M (1985) Enzyme-linked immunosorbend assay for detection of antibodies against human placental syncytio-trophoblat. Am J Reprod Immunol. 7 (4): 131–136
Mettler L, Czuppon AB (1987) Immunologie der Reproduktion. Urban und Schwarzenberg, München Wien Baltimore
Rose NR, Hjort T, Harper MJK, Kyazow 0 (1976) Techniques for detection of iso-and autoantibodies to human spermatozoa. Clin Exp Immunol 23: 175–199
Rümke P (1954) The presence of sperm antibodies in the serum of two patients with oligozoospermia. Vox Sang 4: 136–140
Sacco AG, Shivers CA (1973) Antigens of the rabbit ovary, oviduct and uteru. J Reprod Fertil 23: 403–407
Shivers CA (1976) Antigens of the ovum as a potential base for the development of a contraceptive vaccine. In: Harper M (ed) Development of vaccine for fertility regulation. Scriptor, Kopenhagen
Sims JM (1869) On the microscope as an aid in the diagnosis and treatment of sterility. NY Med J 8: 393–396
Skrabei H, Czuppon AB, Mettler L (1980) Reaction of human spermatozoal haptens with sperm antibody containing sera ( Protein-A tracer RIA ). Arch Androl 5: 13–14
Wilson L (1954) Sperm agglutinins in human semen and blood. Proc Soc Exp Biol Med 85: 652–655
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mettler, L. (1987). Immunologie der Sterilität. In: Künzel, W., Gips, H. (eds) Gießener Gynäkologische Fortbildung 1987. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72704-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-72704-7_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17851-4
Online ISBN: 978-3-642-72704-7
eBook Packages: Springer Book Archive