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Immunologische Ursachen des habituellen Abortus

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Gießener Gynäkologische Fortbildung 1987
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Zusammenfassung

Wenn wir über die immunologischen Voraussetzungen für die intakte Schwangerschaft bzw immunologische Ursachen für den habituellen Abort sprechen, müssen wir uns den sich im mütterlichen Organismus entwickelnden Embryo bzw. Fetus als Transplantat vorstellen. Die Implantation embryonalen Gewebes, das zur Hälfte väterliche, d. h. fremde Eigenschaften trägt, ist die einzige von der Natur vorgesehene und die einzige vom Immunsystem tolerierte Allotransplantation.

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Literatur

  • Beer AE, Quebbeman JF, Ayers JWT, Haines RF (1981) Major histocompatibility complex antigens, maternal and paternal immune responses, and chronic habitual abortions in humans. Am J Obstet Gynecol 141: 987–999

    PubMed  CAS  Google Scholar 

  • Beer AE, Semprini AE, Xiaoyu Z, Quebbeman JF (1985) Pregnancy outcome in human couples with recurrent spontaneous abortions: HLA antigen profiles; HLA antigen sharing; female serum MLR blocking factors; and paternal leukocyte immunization. Exp Clin Immunogenet 2: 137–153

    PubMed  CAS  Google Scholar 

  • Bobé P, Chaouat G, Stanislawski M, Kiger N (1986) Immunogenetic studies of spontaneous abortion in mice. II. Antiabortive effects are independent of systemic regulatory mechanisms. Cell Immunol 98: 477–485

    Article  PubMed  Google Scholar 

  • Davies M (1986) Hypothesis: blocking factors and human pregnancy: an alternative explanation for the success of lymphocyte transfusion therapy in abortion-prone women. Am J Reprod Immunol Microbiol 10: 58–63

    PubMed  CAS  Google Scholar 

  • Faulk WP, McIntyre JA (1983) Immunological studies of human trophoblast: markers, subsets and functions. Immunological Rev 75: 139–175

    Article  CAS  Google Scholar 

  • Gerencer M, Kastelan A, Drazancic A, Kerhin-Brkljacic V, Madjaric M (1978) The HLA antigens in women with recurrent abnormal pregnancies of unknown etiology. Tissue Antigens 12: 223–227

    Article  PubMed  CAS  Google Scholar 

  • Hsi B-L, Yeh C-JG, Faulk WP (1984) Class I antigens of the major histocompatibility complex on cytotrophoblast of human chorion laeve Immunology 52: 621–629

    CAS  Google Scholar 

  • Lala PK, Chatterjee-Hasrouni S, Kearns M, Montgomery B, Colavincenzo V (1983) Immunobiology of the feto-maternal interface. Immunological Rev 75: 87–116

    Article  CAS  Google Scholar 

  • Lauritsen JG, MD, Kristensen T, MD, Grunnet N, MD (1976) Depressed mixed lymphocyte culture reactivity in mothers with recurrent spontaneous abortion. Am J Obstet Gynecol 125: 35–39

    PubMed  CAS  Google Scholar 

  • Lellé RJ, Toboll GK, Maas DHA, Kaulhausen H, Heidenreich W (1986) Bestimmung der Lymphozyten-subpopulationen durch monoklonale Antikörper bei Patientinnen mit habituellen Aborten. Fertilität 2: 4–6

    Google Scholar 

  • Malchus R, Sating E (1986) Immunologische Aspekte bei habitueller Abortneigung. In: Dudenhausen JW, Sating E (Hrsg) Perinatale Medizin. Thieme, Stuttgart, S 45–46

    Google Scholar 

  • McIntyre JA, Faulk WP (1983) Recurrent spontaneous abortion in human pregnancy: results of immunogenetical, cellular, and humoral studies. Am J Reprod Immunol 4: 165–170

    PubMed  CAS  Google Scholar 

  • McIntyre JA, Faulk WP (1985) Laboratory and clinical aspects of research in chronic spontaneous abortion. Diagn Immunol 3: 163–170

    PubMed  CAS  Google Scholar 

  • McIntyre JA, Faulk WP (1986) Immunologic testing and immunotherapy in recurrent spontaneous abortion. Obstet Gynecol 67: 169–175

    Article  PubMed  CAS  Google Scholar 

  • Mowbray JF, Liddell H, Underwood JL, Gibbings C, Reginald PW, Beard RW (1985) Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet I: 941–943

    Article  Google Scholar 

  • Mueller-Eckhardt G (1985) Histokompatibilität and Nierentransplantation. Dialyse-Journal 12: 7–12

    Google Scholar 

  • Nicholas NS, Panayi GS, Murphy J, Pitzalis C (1986) Human retroplacental sera inhibit the expression of class II major histocompatibility antigens. J Reprod Immunol 9: 95–102

    Article  PubMed  CAS  Google Scholar 

  • Power DA, Mather AJ, MacLeod AM, Lind T, Catto GRD (1986) Maternal antibodies to paternal B-lymphocytes in normal and abnormal pregnancy. Am J Reprod Immunol Microbiol 10: 10–13

    PubMed  CAS  Google Scholar 

  • Rocklin RE, Kitzmiller JL, Carpenter CB, Garovoy MR, David JR (1976) Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. N Engl J Med 295: 1209–1213

    Article  PubMed  CAS  Google Scholar 

  • Stewart GM, Mason RJ, Thomson MAR, MacLeod AM, Catto GRD (1984) Noncytotoxic antibodies to paternal antigens in maternal sera and placental eluates. Transplantation 38: 111–115

    Article  PubMed  CAS  Google Scholar 

  • Stimson WH, Strachan AF, Shepherd A (1979) Studies on the maternal immune response to placental antigens: absence of a blocking factor from the blood of abortion-prone women. Br J Obstet Gynaecol 86: 41–45

    Article  PubMed  CAS  Google Scholar 

  • Stray-Pedersen B, Stray-Pedersen S (1984) Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol 148: 140–146

    PubMed  CAS  Google Scholar 

  • Takakuwa K, Kanazawa K, Takeuchi S (1986) Production of blocking antibodies by vaccination with husband’s lymphocytes in unexplained recurrent aborters: the role in successful pregnancy. Am J Reprod Immunol Microbiol 10: 1–9

    PubMed  CAS  Google Scholar 

  • Taylor C, Faulk WP (1981) Prevention of recurrent abortion with leucocyte transfusions. The Lancet 68–70

    Google Scholar 

  • Taylor CG, Faulk WP, McIntyre JA (1985) Prevention of recurrent spontaneous abortions by leukocyte transfusions. J R Soc Med 78: 623–627

    PubMed  CAS  Google Scholar 

  • Toth A, Lesser ML, Brooks-Toth CW, Feiner C (1986) Outcome of subsequent pregnancies following antibiotic therapy after primary or multiple spontaneous abortions. Surg Gynecol Obstet 163: 243–250

    PubMed  CAS  Google Scholar 

  • Unander AM, Olding LB (1983) Habitual abortion: parental sharing of HLA antigens, absence of maternal blocking antibody, and suppression of maternal lymphocytes. Am J Reprod Immunol 4: 171–178

    PubMed  CAS  Google Scholar 

  • Unander M, Lindholm A, Olding LB (1985) Habitual abortion: blocking antibodies and transfusion therapy. (Abstract) Arch Gynecol 237: 227

    Google Scholar 

  • Underwood JL, Mowbray JF (1985) Treatment of recurrent spontaneous abortion. Clin Immunol Allergy 5: 33–42

    Google Scholar 

  • Westphal E (1986) Derzeitiger Stand der Immunisierung bei habituellen Aborten in Deutschland. Vortrag 18. Tagung der Arbeitsgemeinschaft für Histokompatibilitätstestung, Bremen

    Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Mueller-Eckhardt, G. (1987). Immunologische Ursachen des habituellen Abortus. In: Künzel, W., Gips, H. (eds) Gießener Gynäkologische Fortbildung 1987. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72704-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-72704-7_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17851-4

  • Online ISBN: 978-3-642-72704-7

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