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Rat Models of Non-Insulin-Dependent Diabetes Mellitus: Evidence that Mild Increases in Plasma Glucose Play an Important Role in Pathogenesis

  • Chapter
The Pathology of the Endocrine Pancreas in Diabetes

Abstract

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has been the subject of debate for many years, and it still remains poorly understood [55, 82]. Current dogma states that it is a heterogeneous disorder; indeed, several patients have now been identified with mutant insulins [63, 69] or one of a variety of syndromes characterized by abnormal insulin receptors, extreme insulin resistance, and acanthosis nigricans [16,17,29]. Also, in some series, up to 10% are islet cell antibody-positive [14]. However, these groups together represent only a small minority of those with NIDDM, and while new syndromes will probably be described in the future, it seems reasonable to assume that the bulk of patients share a common etiology.

This work has been supported by grant AM-35449 (formerly Am-29349) from the National Institutes of Health, and 185296 from the Juvenile Diabetes Foundation. Dr. Leahy is the recipient of a Research and Development Award from the American Diabetes Association.

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  1. J. L. Leahy
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  2. S. Bonner-Weir
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  3. G. C. Weir
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Editors and Affiliations

  1. Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, B-4000, Liège 1, Belgium

    Pierre J. Lefèbvre

  2. Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium

    Daniel G. Pipeleers

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Leahy, J.L., Bonner-Weir, S., Weir, G.C. (1988). Rat Models of Non-Insulin-Dependent Diabetes Mellitus: Evidence that Mild Increases in Plasma Glucose Play an Important Role in Pathogenesis. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_16

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