Abstract
Despite the voluminous literature which has accumulated during the recent years on the mechanism of action of Interferons (IFNs), there is no unified hypothesis which rationalizes the profound pleiotropic effects manifested by this group of highly bioactive glycoproteins. There is an abundance of information which suggests that the plasma membrane of host cells is the primary target of IFN action, not only in an obvious temporal sequence, but also in demonstrable physical and chemical changes of cell membranes during IFN-cell interactions. Thus, various reports show early and later changes of plasma membranes in both the physical and chemical properties of this subcellular structure (Chandrabose et al. 1981a, 1982;Pfeffer et al. 1980).
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References
Allen G, Fantes KH, Burke DC, Morser J (1982) Analysis and Purification of human lymphoblastoid interferon using a monoclonal antibody. J Gen Virol 63: 207
Apostolov K, Barker W (1984) Cyclic effects of interferon and its antagonist on the saturation of 18 C fatty acids. Ann Virol (Paris) (from preprint submitted to KAC)
Bougnoux P, Salem N, Lyons C, Hoffman T (1985) Alteration in the membrane fatty acid composition of human lymphocytes and cultured transformed cells induced by interferon. Mol Immunol 22: 107
Cassatella MA, Delia Bianea V, Berton G, Rossi F (1985) Activation by gamma interferon of human macrophage capability to produce toxic oxygen molecule is accompanied by decreased Km of the superoxide generating NADPH oxidase. Biochem Biophys Res Commun 132: 908
Chandrabose KA, Cuatrecasas P, Pottathil R (1981a) Changes in fatty acid chains of phospholipids induced by interferon in mouse sarcoma S-180 cells. Biochem Biophys Res Comm 98: 661
Chandrabose KA, Cuatrecasas P, Pottathil R, Lang DJ (1981b) Interferon-resistant cell line lacks fatty acid cyclo-oxygenase. Science 212: 329
Chandrabose KA, Raveendran P, Borden EC, Fox R, Cuatrecasas P (1982) The possible roles of prostaglandin synthetase and cytoplasmic superoxide dismutase in interferon action in homologous cells. In: Prostaglandins and Cancer, First International Conference. Alan R. Liss, New York, pp 345–364
Koizumi A, Walford RL, Imamra T (1986) Treatment with poly IC enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats. Biochem Biophys Res Commun 134: 632
Pfeffer LM, Wang E, Tamm I (1980) Interferon inhibits the re-distribution of cell surface components. J Exp Med 152: 469
Pottathil R, Chandrabose KA, Cuatrecasas P, Lang DJ (1981) Establishment of interferon-mediated antiviral state. Possible role of superoxide dismutase. Proc Natl Acad Sci USA 78: 3343
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© 1987 Springer-Verlag Berlin Heidelberg
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Chandrabose, K.A., Agarwal, S. (1987). Interferon-Induced Modifications of the Fatty Acid Side Chains of Cell Membrane Phospholipids. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_11
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DOI: https://doi.org/10.1007/978-3-642-71904-2_11
Publisher Name: Springer, Berlin, Heidelberg
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