Prostaglandins in Cancer Research

  • Enrico Garaci
  • Rodolfo Paoletti
  • M. Gabriella Santoro
Conference proceedings

Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Introductory Lectures

    1. Front Matter
      Pages 1-1
  3. Carcinogenesis

  4. Cellular and Molecular Mechanisms of PG Action

  5. Cell Proliferation and Differentiation

    1. Front Matter
      Pages 139-139
    2. B. M. Jaffe, M. G. Santoro
      Pages 141-150
    3. M. Hozumi, Y. Honma, T. Kasukabe, J. Okabe-Kado, K. Takenaga
      Pages 151-160
    4. K. V. Honn, D. G. Menter, B. W. Steinert, J. D. Taylor, J. M. Onoda, B. F. Sloane
      Pages 172-183

About these proceedings

Introduction

Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron­ mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol­ ume is based on papers presented at the 1986 International Confer­ ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as­ pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos­ sible use of some of these compounds as antineoplastic agents.

Keywords

biochemistry biology cancer cancer research carcinogenesis cell chemistry evolution hormones metastasis molecular biology pharmacology prostaglandins regulation tumor

Editors and affiliations

  • Enrico Garaci
    • 1
  • Rodolfo Paoletti
    • 2
  • M. Gabriella Santoro
    • 3
  1. 1.Department of Experimental MedicineII University of RomeRomeItaly
  2. 2.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  3. 3.Institute of Experimental Medicine, CNRII University of RomeRomeItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71904-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71906-6
  • Online ISBN 978-3-642-71904-2
  • Series Print ISSN 0172-6625
  • About this book