Abstract
Alterations in sympathetic activity might play an important role in inducing and/or maintaining elevated blood pressure in essential hypertension (De Champlain 1978; Folkow 1982; Weber and Drayer 1982). Because of the lack of a direct measurement of sympathetic activity in man, plasma noradrenaline concentrations have been taken as an index of sympathetic activity. Although numerous comparative studies of plasma catecholamines in hypertensives and normotensive controls exist, it is still a matter of controversy whether plasma noradrenaline levels are increased in essential hypertension (for a recent review see Goldstein 1983).
This work was supported by the Landesamt für Forschung Nordrhein-Westfalen and the SANDOZ-Stiftung für Therapeutische Forschung.
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References
Aarons RD, Nies AS, Gal J, Hegstrand LR, Molinoff PB (1980) Elevation of β-adrenergic receptor density in human lymphocytes after propranolol administration. J Clin Invest 65: 949–957
Boon NA, Elliot JM, Davies CL, Conway FJ, Grahame-Smith DG, Sleight P (1983) Platelet a-adrenoceptors in borderline and established essential hypertension. Clin Sci 65: 207–208
Brodde O-E, Engel G, Hoyer D, Bock KD, Weber F (1981) The β-adrenergic receptor in human lymphocytes: Subclassification by the use of a new radio-ligand, (±)-125iodocyanopindolol. Life Sci 29: 2189–2198
Brodde O-E, Anlauf M, Graben N, Bock KD (1982) In vitro and in vivo down-regulation of human platelet α2-adrenoceptors by Clonidine. Eur J Clin Pharmacol 23: 403–409
Brodde O-E, Prywarra A, Daul A, Anlauf M, Bock KD (1984) Correlation between lymphocyte β2-adrenoceptor density and mean arterial blood pressure: elevated β-adrenoceptors in essential hypertension. J Cardiovasc Pharmacol 6: 678–682
Brodde O-E, Daul A, O’Hara N, Khalifa AM (1985 a) Properties of a- and β-adrenoceptors in circulating blood cells of patients with essential hypertension. J Cardiovasc Pharmacol 7 [Suppl 6]: S162–S167
Brodde O-E, Stuka N, Demuth V, Fesel R, Bergerhausen J, Daul A, Bock KD (1985 b) Alpha- and beta-adrenoceptors in circulating blood cells of essential hypertensive patients: increased receptor density and responsiveness. Clin Exp Hypertens [A] 7: 1135–1150
Brodde O-E, Daul A, Stuka N, O’Hara N, Borchard U ( 1985 c) Effects of β-adrenoceptor antagonist administration on β2-adrenoceptor density in human lymphocytes. The role of the “intrinsic sympathomimetic activity”. Naunyn Schmiedebergs Arch Pharmacol 328: 417–422.
Brodde O-E, Schemuth R, Brinkmann M, Wang XXL, Daul A, Borchard U (1986) β-Adrenoceptor antagonists (non-selective as well as β1-selective) with partial agonistic activity decrease β2-adrenoceptor density in human lymphocytes. Evidence for a β2-agonistic component of the partial agonistic activity. Naunyn-Schmiedebergs Arch Pharmacol (in press)
De Champlain J (1978) The contribution of the sympathetic nervous system to arterial hypertension. Can J Physiol Pharmacol 56: 341–353
Engberg G, Elam M, Svensson TH (1982) Clonidine withdrawal: activation of brain noradrenergic neurons with specifically reduced α2-receptor sensitivity. Life Sci 30: 235–243
Eymer TH, Arroyo J, Prywarra A, Brodde O-E (1982) Properties of α2-adrenoceptors in human platelets, guinea-pig kidney and calf cerebral cortex as evaluated by 3H-yohimbine binding. Naunyn-Schmiedebergs Arch Pharmacol 321 [Suppl R]: 257
Folkow B (1982) Physiological aspects of primary hypertension. Physiol Rev 62: 347–504
Goldstein DS (1983) Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5: 86–99
Giudicelli Y, Lacasa D, Agli B, Leneveu A (1984) Comparison of changes in the characteristics of β-adrenoceptors and responsiveness in human circulating lymphocytes during chronic and after chronic administration of pindolol and propranolol. Eur J Clin Pharmacol 26: 7–12
Kafka MS, Lake CR, Gullner H-G, Tallmann JF, Bartter FC, Fujita T (1979) Adrenergic receptor function is different in male and female patients with essential hypertension. Clin Exp Hypertens 1: 613–627
Kobinger W (1978) Central «-adrenergic systems as target for hypotensive drugs. Rev Physiol Biochem Pharmacol 81: 40–100
Landmann R, Burgisser E, Buhler FR (1983) Human lymphocytes as a model for beta-adrenergic receptors in clinical investigation. J Recent Res 3: 71–88
McDevitt DG (1979) Adrenoceptor blocking drugs: clinical pharmacology and therapeutic use. Drugs 17: 267–288
Middeke M, Remien J, Holzgreve H (1984) The influence of sex, age, blood pressure and physical stress on β2-adrenoceptor density in mononuclear cells. J Hypertens 2: 261–264
Molinoff PB, Aarons RD (1983) Effects of drugs on β-adrenergic receptors on human lymphocytes. J Cardiovasc Pharmacol 5 [Suppl 1]: S 63–S 67
Motulsky H J, O’Connor DT, Insel PA (1983) Platelet α2-adrenergic receptors in treated and untreated essential hypertension. Clin Sci 64: 265–272
Prichard BNC (1978) Beta-adrenergic receptor blockade in hypertension, past, present and future. Br J Clin Pharmacol 5: 379–399.
Prichard BNC, Tomlinson B, Walden RJ, Bhattacharjee P (1983) The β-adrenergic blockade withdrawal phenomenon. J Cardiovasc Pharmacol 5 [Suppl 1]: S 56–S 62
Scatchard G (1949) The attraction of proteins for small molecules and ions. Ann N Y Acad Sci 51: 660–672
Schmitt H (1977) The pharmacology of clonidine and related products. In: Gross F (ed) Antihypertensive drugs. Handbook of Experimental Pharmacology, vol 39. Springer-Verlag, Berlin Heidelberg New York, pp 299–396
Scriabine A (1979) β-Adrenoceptor blocking drugs in hypertension. Annu Rev Pharmacol Toxicol 19:269–284
Starke K (1977) Regulation of noradrenaline release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 77: 1–124
Summers RJ, Barnett DB, Nahorski SR(1983) The characteristics of adrenoceptors in homogenates of human cerebral cortex labelled by 3H-rauwolscine. Life Sci 33: 1105–1112
Szecsi E, Kohlschutter S, Schiess W, Lang E (1982) Abrupt withdrawal of pindolol or metoprolol after chronic therapy. Br J Clin Pharmacol 13 [Suppl 2]: 353S–357S
Walden RJ, Bhattacharjee P, Tomlinson B, Cashin J, Graham BR, Prichard BNC (1982) The effect of intrinsic sympathomimetic activity on β -receptor responsiveness after β-adrenoceptor blockade withdrawal. Br J Clin Pharmacol 13 [Suppl 2]: 359S–364S
Weber MA (1980) Discontinuation syndrome following cessation of treatment with clonidine and other antihypertensive agents. J Cardiovasc Pharmacol 2 [Suppl I]: S73–S89
Weber MA, Drayer JIM (1982) The sympathetic nervous system in primary hypertension. Miner Electrolyte Metab 7: 57–66
Wood AJJ, Feldman R, Nadeau J (1982) Physiological regulation of beta-receptors in man. Clin Exp Hypertension [A] 4: 807–817
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© 1986 Springer-Verlag Berlin Heidelberg
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Daul, A., O’Hara, N., Wang, X.L., Brodde, OE. (1986). Effects of Antihypertensive Agents on Alpha and Beta Adrenoceptors. In: Middeke, M., Holzgreve, H. (eds) New Aspects in Hypertension Adrenoceptors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71418-4_17
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DOI: https://doi.org/10.1007/978-3-642-71418-4_17
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