New Aspects in Hypertension Adrenoceptors

  • Martin Middeke
  • Heinrich Holzgreve
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XII
  2. M. Minuth, S. Bauer, R. Grandt, C. Greiner, P. Zubin, K. H. Jakobs
    Pages 74-80
  3. M. Middeke
    Pages 103-116
  4. G. Bruschi, M. E. Bruschi, A. Cavatorta, A. Borghetti
    Pages 117-125
  5. E. Fritschka, A. Kribben, S. Harwig, H. Haller, T. Lenz, H. M. Thiede et al.
    Pages 146-154
  6. B. N. C. Prichard, F. Bompart
    Pages 166-191
  7. A. Daul, N. O’Hara, X. L. Wang, O.-E. Brodde
    Pages 193-207
  8. J. M. Cruickshank
    Pages 208-230
  9. Back Matter
    Pages 231-233

About these proceedings

Introduction

This book reports on the current state of knowledge about adreno­ ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit­ ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under­ standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica­ tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ­ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be­ coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel­ opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph­ eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions.

Keywords

blood pressure calcium hypertension pharmacology platelet research

Editors and affiliations

  • Martin Middeke
    • 1
  • Heinrich Holzgreve
    • 1
  1. 1.Medizinische Poliklinik der Ludwig-Maximilians-Universität MünchenMünchen 2Federal Republic of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71418-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71420-7
  • Online ISBN 978-3-642-71418-4
  • About this book