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Effect of Fludrocortisone on Adrenoceptors and Free Intracellular Calcium in Man

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New Aspects in Hypertension Adrenoceptors

Abstract

The mineralocorticoid - induced blood pressure increase in normotensive man is characterized by an early rise in cardiac output during the 1st week of steroid administration and a persistent increase in total peripheral resistance (TPR), which is observed later on, when cardiac output returns to pretreatment values [1,2]. The initial rise in cardiac output has been linked to sodium and volume retention [3,4]. The mechanism of the persistent increase in TPR in the presence of a normal or subnormal cardiac output remains elusive. Alterations of sympathetic nervous system activity and increased passive membrane permeability for sodium have been observed in animal models of mineralocorticoid hypertension [5, 6]. The present study examined parameters of sympathetic activity and intracellular calcium concentration, which ultimately should be linked to altered cellular sodium transport [7] in normotensive volunteers, in whom a mineralocorticoid-induced blood pressure increase was evoked by oral administration of fludrocortisone.

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Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Klinikum Steglitz, Freie Universität Berlin, 1000, Berlin 45, Federal Republic of Germany

    E. Fritschka, A. Kribben, S. Harwig, H. Haller, T. Lenz, H. M. Thiede, M. Luedersdorf & A. Distler

Authors
  1. E. Fritschka
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  2. A. Kribben
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  3. S. Harwig
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  4. H. Haller
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  5. T. Lenz
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  6. H. M. Thiede
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  7. M. Luedersdorf
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  8. Th. Philipp
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  9. A. Distler
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Editor information

Editors and Affiliations

  1. Medizinische Poliklinik der Ludwig-Maximilians-Universität München, Pettenkoferstr. 8 a, 8000, München 2, Federal Republic of Germany

    Martin Middeke  & Heinrich Holzgreve  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Fritschka, E. et al. (1986). Effect of Fludrocortisone on Adrenoceptors and Free Intracellular Calcium in Man. In: Middeke, M., Holzgreve, H. (eds) New Aspects in Hypertension Adrenoceptors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71418-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-71418-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71420-7

  • Online ISBN: 978-3-642-71418-4

  • eBook Packages: Springer Book Archive

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