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Pharmacokinetic Considerations Relevant to the Pharmacodynamics of Antidepressants

  • Conference paper
Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

Abstract

In the course of development of new drugs there is a tendency to think and plan, on both conscious and unconscious levels, on the basis of the experience with existing therapeutics. Often, therefore, the development of new antidepressants has been based on knowledge collected with tricyclic antidepressants or MAO inhibitors. The experimental pharmacodynamics of tricyclics in particular has played a dominant role in the development of models for the mode of action of antidepressants and hence in the development of rational drugs with selective effects. On the clinical side our planning is also influenced by earlier experience, when side effects are recorded or when pharmacokinetic studies are designed, for example. Our experience with earlier drugs should be the inspiration and not the limitation of our research on new compounds. What we must do, then, is distil the essence of the earlier experience that can be expected to be relevant for the new drugs.

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Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Odense University, School of Medicine, J. B. Winslöwsvej 19, DK-5000, Odense, Denkmark

    L. F. Gram, K. Brøsen & P. Christensen

  2. Department of Psychiatry, Odense University, School of Medicine, J. B. Winslowsvej 19, DK-5000, Odense, Denkmark

    P. Kragh-Sørensen

Authors
  1. L. F. Gram
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  2. K. Brøsen
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  3. P. Christensen
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  4. P. Kragh-Sørensen
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, N-9001, Tromsø, Norway

    Svein G. Dahl Cand Real, Dr. Philos. (Professor of Pharmacology) (Professor of Pharmacology)

  2. Department of Clinical Pharmacology, School of Medicine, Odense University, DK-5000, Odense C, Denmark

    Lars F. Gram MD (Professor of Clinical Pharmacology) (Professor of Clinical Pharmacology)

  3. Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, 20205, Bethesda, MD, USA

    Steven M. Paul MD (Chief) (Chief)

  4. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, 20205, Bethesda, MD, USA

    William Z. Potter MD, PhD (Chief) (Chief)

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© 1987 Springer-Verlag Berlin Heidelberg

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Gram, L.F., Brøsen, K., Christensen, P., Kragh-Sørensen, P. (1987). Pharmacokinetic Considerations Relevant to the Pharmacodynamics of Antidepressants. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

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