Summary
Human platelets have been shown to possess high-affinity binding sites for 3H-imipramine. These binding sites have a similar affinity and drug specificity to those already described in rat brain. The platelets from healthy volunteers show no difference in 3H-imipramine binding between the sexes but there is a decrease in maximal 3H-imipramine binding with increasing age of the donor.
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Langer, S.Z., Briley, M.S., Raisman, R. et al. Specific 3H-imipramine binding in human platelets. Naunyn-Schmiedeberg's Arch. Pharmacol. 313, 189–194 (1980). https://doi.org/10.1007/BF00505732
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DOI: https://doi.org/10.1007/BF00505732