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Alkohol und Hirnatrophie

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Das Verhältnis der Psychiatrie zu ihren Nachbardisziplinen

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Zusammenfassung

Unter dem Begriff einer Atrophie versteht die Allgemeine Pathologie den Verlust an Volumen bzw. Masse, also eine Verkleinerung entweder von Zellen oder von Geweben oder Organen. Übertragen wir dies auf das Hirngewebe Alkoholsüchtiger, so können wir hier unterscheiden eine einfache Atrophie einzelner Rinden-Nervenzellen (Abb.1), eine Atrophie größerer Rindenabschnitte — hier entweder als Atrophie der Großhirnrinde (Abb.2) oder des Vorderwurms des Kleinhirns (Abb.3u.4) oder auch eine Atrophie des ganzen Organs (Abb.5).

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Literatur

  • Acker W, Aps EJ, Majumdar Sisir K, Shah GK, Thomson AD (1982) The relationship between brain and liver damage in chronic alcoholic patients. J Neurol Neurosurg Psychiat 45: 984–987

    Article  PubMed  CAS  Google Scholar 

  • Allen RP, Faillace LA, Reynolds DM (1971) Recovery of memory functioning in alcoholics following prolonged alcohol intoxication. J nerv ment Dis 153: 417–423

    PubMed  CAS  Google Scholar 

  • Alling Ch, Aspenström G, Dencker SJ, Svennerholm L (1979) Essential fatty acids in chronic alcoholism. Acta med scand, Suppl 631

    Google Scholar 

  • Anderson WJ, Sides GR (1979) Alcohol induced defects in cerebellar development in the rat. Current Alcoholism 5: 123–133

    Google Scholar 

  • Artmann H, Gall MV, Hacker H, Herrlich J (1981) Reversible enlargement of cerebral spinal fluid spaces in chronic alcoholics. Amer J Neurorad 2: 23–27

    CAS  Google Scholar 

  • Askew WE, Charalampous KD (1977) Cyclic AMP and Ethanol with-drawal in the mouse cerebellum. In: Seixas FA (ed) Currents in alcoholism. Vol 1, Grune & Stratton, New York

    Google Scholar 

  • Baldy-Moulinier M, Bories P, Michel H, Passouant P (1977) Encéphalopathies hépatiques; Etude hémodynamique et métabolique de l’influence de l’ammoniaque et de la L. Dopa. Rev neurol 133: 175–189

    CAS  Google Scholar 

  • Bauer-Moffett C, Altman J (1975) Ethanol-induced reduction in cerebellar growth of infant rats. Exp Neurol 48: 378–382

    Article  PubMed  CAS  Google Scholar 

  • Bauer-Moffett C, Altman J (1977) The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study. Brain Res 119: 249–268

    Article  PubMed  CAS  Google Scholar 

  • Bergman H, Borg S, Hindmarsh T, Ideström CM, Mützell S (1979) Computed tomography of the brain and neuropsychological assessment of alcoholic patients. In: Begleiter H, Kissin B (eds) Proceedings from the Fourth Biennial International Symposium on Biological Research in Alcoholism. Plenum Press, New York

    Google Scholar 

  • Berlit P (1982) Neurologische Schädigungen bei chronischem Alkoholismus. Dtsch Ärzteblatt 1: 41–50

    Google Scholar 

  • Berlit P, Krause KH (1981) Die Hirnembolie bei der kongestiven Kardiomyopathie des Alkoholikers. Nervenarzt 52: 605–607

    PubMed  CAS  Google Scholar 

  • Cala LA, Jones B, Mastaglia FL, Wiley B (1978) Brain atrophy and intellectual impairment in heavy drinkers. Aust NZ J Med 8: 147–153

    Article  CAS  Google Scholar 

  • Carlen PL, Wilkinson DA, Kiraly LT (1976) Dementia in alcoholics: A longitudinal study including some reversible aspects. Neurology 26: 355

    Google Scholar 

  • Carlen PL, Wortzman G, Holgate RC, Wilkinson DA, Rankin JG (1978) Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science 200: 1076–1078

    Article  PubMed  CAS  Google Scholar 

  • Carmichael EA, Stern EO (1931) Korsakow’s syndrome. Brain 54: 183–213

    Article  Google Scholar 

  • Charness ME, Gordon AS, Diamond I (1983) Alcohol produces changes in opiate receptors which may correspond to intoxication, tolerance, and withdrawal. Neurology 33, Suppl 2:175

    Google Scholar 

  • Clarke J, Haughton H (1975) A study of intellectual impairment and recovery rates in heavy drinkers in Ireland. Brit J Psychiat 126: 178–184

    Article  PubMed  CAS  Google Scholar 

  • Colmant HJ (1965) Enzephalopathien bei chronischem Alkoholismus. Enke, Stuttgart

    Google Scholar 

  • Craig JR, Johnson L, Lundberg GD, Tatter D, Edmondson HA, McGah S (1980) An autopsy survey of clinical and anatomic diagnoses associated with alcoholism. Arch Path Lab Med 104: 452–455

    PubMed  CAS  Google Scholar 

  • Creutzfeldt HG (1928) Hirnveränderungen bei Gewohnheitstrinkern. Zbl Neurol Psychiat 50: 321

    Google Scholar 

  • Detering N, Edwards E, Ozand P, Karahasan A (1980) Comparative effects of ethanol and malnutrition on the development of catecholamine neurons: Changes in specific activities of enzymes. J Neurochem 34: 297–304

    Article  PubMed  CAS  Google Scholar 

  • Diemer NH, Laursen H (1977) Glial cell reactions in rats with hyperammoniemia induced by urease or porto-caval anastomosis. Acta neurol scand 55: 425–442

    Article  PubMed  CAS  Google Scholar 

  • Epstein PS, Pisani VD, Fawcett JA (1977) Alcoholism and cerebral atrophy. Alcoholism 1: 61–65

    PubMed  CAS  Google Scholar 

  • Ferrer I, Fabregues I, Pineda M, Gracia I, Ribalta T (1984) A Golgi study of cerebellar atrophy in human chronic alcoholism. Neuropath App Neurobiol 10: 245–253

    Article  CAS  Google Scholar 

  • Fitzhugh LC, Fitzhugh KB, Reitan RM (1960) Adaptive abilities and intellectual functioning in hospitalized alcoholics. Quart J Stud Alc 21: 414–423

    CAS  Google Scholar 

  • Fitzhugh LC, Fitzhugh KB, Reitan RM (1965) Adaptive abilities and intellectual functioning of hospitalized alcoholics: further consideration. Quart J Stud Alc 26: 402–411

    CAS  Google Scholar 

  • Fox JH, Ramsey RG, Huckman MS, Proske AE (1976) Cerebral ventricular enlargement. Chronic alcoholics examined by computerized tomography. J Amer med Ass 236: 365

    Article  CAS  Google Scholar 

  • Fuentès C, Michel H, Roch G, Marty R (1982) A propos d’un cas d’encephalopathie cirrhotique alcoolique. Acta Neuropath 58: 17–26

    Article  PubMed  Google Scholar 

  • Gall M v, Becker H (1978) Zur Anwendung der Computertomographie (CT) in der klinischen Psychiatrie. Fortschr Neurol Psychiat 46: 361–368

    CAS  Google Scholar 

  • Goldstein B, Maxwell DS, Ellison G, Hammer RP (1983) Dendritic vacuolization in the central nervous system of rats after longterm voluntary consumption of ethanol. J Neuropath Exp Neurol 42: 579–589

    Article  PubMed  CAS  Google Scholar 

  • Götze P, Kühne D, Hansen J, Knipp HP (1978) Hirnatrophische Veränderungen bei chronischem Alkoholismus. Arch Psychiat Nervenkr 226: 137–156

    Article  PubMed  Google Scholar 

  • Harper CG (1979) Wernicke’s encephalopathy: A more common disease than realised. J Neurol Neurosurg Psychiat 42: 226–231

    Article  PubMed  CAS  Google Scholar 

  • Harper CG, Blumbergs PC (1982) Brain weights in alcoholics. J Neurol Neurosurg Psychiat 45: 838–840

    Article  PubMed  CAS  Google Scholar 

  • Heidemann E (1984) Die Blutbildung und das Immunsystem unter Alkoholeinwirkung. DMW 109: 1247–1248

    Article  CAS  Google Scholar 

  • Heinicke EA (1982) The effect of acute ethanol intoxication and chronic ethanol comsumption on vascular permeability around cerebral stab wounds in mice. Acta Neuropath 56: 273–278

    Article  PubMed  CAS  Google Scholar 

  • Hillbom M, Kaste M (1981) Does alcohol intoxication precipitate aneurysmal subarachnoid haemorrhage? J Neurol Neurosurg Psychiat 44: 523

    Article  PubMed  CAS  Google Scholar 

  • Hillbom M, Kaste M (1982) Alcohol intoxication: A risk factor for primary subarachnoid hemorrhage. Neurology 32: 706–711

    PubMed  CAS  Google Scholar 

  • Hillbom M, Kaste M, Rasi V (1983) Can ethanol intoxication affect hemocoagulation to increase the risk of brain infarction in young adults? Neurology 33: 381–384

    PubMed  CAS  Google Scholar 

  • Horrobin DF (1980) A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: Interference with essential fatty acid and prostaglandin metabolism. Med Hypotheses 6: 929–942

    Article  PubMed  CAS  Google Scholar 

  • Hubbard BM, Anderson JM (1981) Age, senile dementia and ventricular enlargement. J Neurol Neurosurg Psychiat 44: 631–635

    Article  PubMed  CAS  Google Scholar 

  • Huber G (1980) Was erwartet der Psychiater von der Computertomographie? Fortschr Neurol Psychiat 48: 385

    Article  CAS  Google Scholar 

  • Huber G, Gross G, Schüttler R, Wappenschmidt J (1982) Hirnatrophische Prozesse. In: Wieck HH, Schrader A, Daun H, Witkowski R (Hrsg) Krankheit Alkoholismus. Perimed Fachbuch-Verlagsgesellschaft, Erlangen

    Google Scholar 

  • Issa FG, Sullivan CE (1982) Alcohol, snoring and sleep apnoea. J. Neurol Neurosurg Psychiat 45:353–359

    Article  PubMed  CAS  Google Scholar 

  • Jakob A (1912) Zur Klinik und pathogenetischen Anatomie des chronischen Alkoholismus, zugleich ein Beitrag zu den Erkrankungen des Kleinhirns. Z Neur 13: 132–152

    Google Scholar 

  • Jellinger K, Riederer P, Kleinberger G, Wuketisch St, Kothbauer P (1978) Brain monoamines in human hepatic encephalopathy. Acta Neuropath 43: 63–68

    Article  PubMed  CAS  Google Scholar 

  • Kornguth SE, Rutledge JJ, Sunderland E et al. (1979) Impeded cerebellar development and reduced serum thyroxine levels associated with fetal alcohol intoxication. Brain Res 177: 347–360

    Article  PubMed  CAS  Google Scholar 

  • Larbi EB, Cooper RS, Stamler J (1983) Alcohol and hypertension. Arch intern Med 143:28–29 Lee K, Moller L, Hardt F, Haubek A, Jensen E (1979) Alcohol-induced brain damage and liver damage in young males. Lancet II: 759–761

    Google Scholar 

  • Lishman WA (1981) Cerebral disorder in alcoholism syndromes of impairment. Brain 104: 1–20

    Article  PubMed  CAS  Google Scholar 

  • Lishman WA, Ron M, Acker W (1980) Computed tomography of the brain and psychometric assessment of alcoholic patients — a British study. In: Sandler M (ed) Psychopharmacology of alcohol. Raven Press, New York, pp 33–41

    Google Scholar 

  • Marie P, Foix C, Alajouanine T (1922) De l’atrophie cérébelleuse tardive à prédominance corticale. Revue neur 29: 849, 1082

    Google Scholar 

  • Meyer E (1912) Zur pathologischen Anatomie des Korsakowschen Symptomen-Komplexes alkoholischen Ursprungs. Arch Psychiat 49: 469–481

    Article  Google Scholar 

  • Morel F (1939) Une forme anatomo-clinique particulière de l’alcoolisme chronique: sclérose corticale laminaire alcoolique. Rev Neurol 71: 280–288

    Google Scholar 

  • Myers RD (1978) Psychopharmacology of alcohol. Ann Res Pharmacol Toxicol 18: 125–144

    Article  CAS  Google Scholar 

  • Neubürger K (1931) Über Hirnveränderungen nach Alkoholmißbrauch (unter Berücksichtigung einiger Fälle von Wernickescher Krankheit mit anderer Ätiologie). Z Neurol Psychiat 135: 159–209

    Article  Google Scholar 

  • Neubürger K (1957) The changing neuropathologic picture of chronic alcoholism. AMA Arch Path 63: 1–6

    Google Scholar 

  • Noble EP, Tewari S (1973) Protein und ribonucleic acid metabolism in brains of mice following chronic alcohol consumption. New York Acad Sci 215: 333–345

    Article  CAS  Google Scholar 

  • Noble EP, Tewari S (1975) Ethanol and brain ribosomes. Fed Proc 34: 1942–1947

    PubMed  CAS  Google Scholar 

  • Nordberg A, Larsson C, Perdahl E, Winblad B (1982) Cholinergic activity in hippocampus in chronic alcoholism. Drug Alcohol Dependence 10: 33–344

    Article  Google Scholar 

  • Page RD, Linden JD (1974) „Reversible“organic brain syndrome in alcoholics. Quart J Stud Alc 35: 98–107

    Google Scholar 

  • Peiffer J (1982) Pathologie des Zentralnervensystems bei chronischem Alkoholismus. In: Krankheit Alkoholismus. Perimed-Fachbuchgesellschaft, Erlangen

    Google Scholar 

  • Pierson CA, Kirscher JP (1954) La dilatation atrophique des ventricules cerebraux favorise-telle l’apprarition de l’alcoholique recidivant. Maroc Med 33:1095

    PubMed  CAS  Google Scholar 

  • Rawat AK (1975) Ribosomal protein synthesis in the fetal and neonatal rat brain as influenced by maternal ethanol consumption. Res Commun chem Path Pharmacol 12: 723–732

    CAS  Google Scholar 

  • Rawat AK (1976) Effect of maternal ethanol consumption on fetal and neonatal rat hepatic protein synthesis. Biochem J 160: 651–653

    Google Scholar 

  • Rawat AK (1979) Derangement in cardiac protein metabolism in fetal alcohol syndrome. Res Commun chem Path Pharmacol 25: 365–375

    CAS  Google Scholar 

  • Reggiani A, Barbaccia ML, Spano PF, Trabucchi M (1980) Dopamine metabolism and receptor function after acute and chronic ethanol. J Neurochem 35: 34–37

    Article  PubMed  CAS  Google Scholar 

  • Riley JN, Walker DW (1978) Morphological alterations in hippocampus after long-term alcohol consumption in mice. Science 201: 646–648

    Article  PubMed  CAS  Google Scholar 

  • Ron MA (1977) Brain damage in chronic alcoholism: A neuropathological, neuroradiological and psychological review. Psychol Med 7: 103–112

    Article  PubMed  CAS  Google Scholar 

  • Ron MA, Acker W, Lishman WA (1979) Dementia in chronic alcoholism. In: Obiols J, Monclus EG, Pujol J (eds) Biological psychiatry today. Elsevier North-Holland Biomedical Press, Amsterdam

    Google Scholar 

  • Rubin E, Rottenberg H (1982) Ethanol-induced injury and adaptation in biological membranes. Fed Proc 41: 2465–2471

    PubMed  CAS  Google Scholar 

  • Skullerud K, Torp T (to be published) Brain weight and volume of lateral ventricles in male alcoholics. Zbl allg Pathol Anat

    Google Scholar 

  • Soininen H, Puranen M, Riekkinen PJ (1982) Computed tomography findings in senile dementia and normal aging. J Neurol Neurosurg Psychiat 45: 50–54

    Article  PubMed  CAS  Google Scholar 

  • Sun AY, Sun GY, Middleton ChC (1977) Alcohol-membrane interaction in the brain: Effect of chronic ethanol administration. In: Seixas FA (ed) Currents in alcoholism. Biological, biochemical, and clinical studies, vol I. Grune & Stratton, New York

    Google Scholar 

  • Schomerus H (1977) Reversible Störungen der Sauerstoffaufnahme und ihre Beziehung zur portocavalen Encephalopathie. Verlaufsuntersuchungen an Patienten mit Lebercirrhose. Habilitationsschrift, Universität Tübingen

    Google Scholar 

  • Stender A, Lüthy F (1931) Über Spätatrophie der Kleinhirnrinde bei chronischem Alkoholismus. Dtsch Zschr Nervenkh 119: 604–622

    Google Scholar 

  • Stoltenburg-Didinger G, Spohr HL, Chahout J (1982) Animal studies of postnatal brain development in fetal alcohol syndrome. IXth International Congress of Neuropathology. Vienna. Abstract B 3–20

    Google Scholar 

  • Thomas A (1905) Atrophie lamellaire des cellules de Purkinje. Revue neur 13: 917

    Google Scholar 

  • Torvik A, Lindhoe CF, Rodge S (1982) Brain lesions in alcoholics. J Neurol Sci 56: 233–248

    Article  PubMed  CAS  Google Scholar 

  • Victor M, Banker BQ (1978) Alcohol and dementia. In: Kathman R, Terry RD, Bick KL (eds) Alzheimer’s disease: Senile dementia and related disorders (Aging, vol 7). Raven Press, New York, pp 149–172

    Google Scholar 

  • Victor M, Laureno R (1978) Neurologic complications of alcohol abuse: Epidemiologic aspects. In: Schoenberg BS (ed) Advances in neurology, vol 19. Raven Press, New York, pp 603–617

    Google Scholar 

  • Volk B (1977) Delayed cerebellar histogenesis in embryofetal alcohol syndrome. Light microscopic study of the rat cerebellum. Acta Neuropath 39: 157–163

    Article  PubMed  CAS  Google Scholar 

  • Volk B (1980) Paired helical filaments in rat spinal ganglia following chronic alcohol administration: An electron microscopic investigation. Neuropath App Neurobiol 6: 143: 153

    Google Scholar 

  • Volk B (1984a) Cerebellar histogenesis and synaptic maturation following pre- and postnatal alcohol administration. Alcohol Neuropath 63: 57–65

    Article  CAS  Google Scholar 

  • Volk B (1984b) Neurohistological and neurobiological aspects of fetal alcohol syndrome in the rat. In: Yanai J (ed) Neurobehavioral teratology. Elsevier, Amsterdam Oxford New York, pp 163–193

    Google Scholar 

  • Volk B, Beriet HH, Maletz J (1980) The influence of alcohol on cerebellar histo- and synaptogenesis. Light and electron microscopic histochemical and neurochemical investigations of the rat cerebellar cortex. Drug Alcohol Depend 6: 67

    Article  Google Scholar 

  • Wartburg JP v (1976) Biologic aspects of alcohol: an introduction. Ann NY Acad Sci 273: 146–150

    Article  Google Scholar 

  • Wasterlain CG, Lockwood AH, Conn M (1978) Chronic inhibition of brain protein synthesis after portocaval shunting. Neurology 28: 233–238

    PubMed  CAS  Google Scholar 

  • Wilkinson DA (1982) Examination of alcoholics by computed tomographic (CT) scans: A critical review. Alcoholism: Clin Exp Res 6: 31–45

    Article  CAS  Google Scholar 

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  1. J. Peiffer
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  1. Psychiatrischen Universitätsklinik, Osianderstraße 22, D-7400, Tübingen, Deutschland

    Hans Heimann (Direktor) & Hans Jörg Gaertner (Oberarzt) (Direktor) &  (Oberarzt)

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Peiffer, J. (1986). Alkohol und Hirnatrophie. In: Heimann, H., Gaertner, H.J. (eds) Das Verhältnis der Psychiatrie zu ihren Nachbardisziplinen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70952-4_27

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  • DOI: https://doi.org/10.1007/978-3-642-70952-4_27

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