Abstract
Historically, oxytocin biosynthesis has always been associated with the synthesis of the chemically related hormone vasopressin. Although the two hormones pursue quite different functions in the mammal, oxytocin being primarily associated with smooth muscle contraction of the female reproductive system and vasopressin with vasopressor and antidiuretic activities, two types of evidence have linked these hormones together.
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References
Acher R (1979) Neurophysine - molekulare und zelluläre Aspekte. Angew Chemie 91:905–919
Ang VTY, Jenkins JS (1984) Neurohypophyseal hormones in the adrenal medulla. J Clin Endocrinol Metab 58:688–691
Angal S, Chaiken M (1982) Interdependence of neurophysin self-association and neuropeptide hormone binding is expressed by quantitative affinity chromatography. Biochemistry 21:1574–1580
Baltimore D (1981) Gene conversion: some implications for immunoglobulin genes. Cell 24:592–594
Bargmann W, Scharrer E (1951) The site of origin of the hormones of the posterior pituitary. Am Sci 39:255–259
Bradbury AF, Finnie MDA, Smyth DG (1982) Mechanism of C-terminal amide formation by pituitary enzymes. Nature 298:686–688
Breslow E (1979) Chemistry and biology of the neurophysins. Annu Rev Biochem 48:251–274
Brimble MJ, Dyball REJ (1977) Characterization of the responses of oxytocin and vasopressin secretory neurones in the supraoptic nucleus to osmotic stimulation. J Physiol 271:253–271
Burford GD, Robinson ICAF (1982) Oxytocin, vasopressin and neurophysins in the hypothalamo-neurohypophyseal system of the human fetus. J Endocrinol 95:403–408
Camier M, Barre N, Cohen P (1985) Hypothalamic biosynthesis and transport of neurophysins and their precursors to the rat brain stem. Brain Res 334:1–8
Dierickx K, Vandesande F (1979) Immunocytochemical demonstration of separate vasopressin-neurophysin and oxytocin-neurophysin neurons in the human hypothalamus. Cell Tissue Res 196:203–212
Fields PA, Eldridge RK, Fuchs A-R, Roberts RF, Fields MJ (1983) Human placental and bovine corpora luteal oxytocin. Endocrinology 112:1544–1546
Flint APF, Sheldrick EL (1982) Ovarian secretion of oxytocin is stimulated by prostaglandin. Nature 297:587–588
Franco-Bourland RE, Fernstrom JD (1981) In vivo biosynthesis of the L-(35S)Cys-arginine vasopressin, -oxytocin and -somatostatin: rapid estimation using reversed phase high pressure liquid chromatography. Endocrinology 109:1097–1106
Furutani Y, Morimoto Y, Shibahara S, Noda M, Takahashi H, Hirose T, Asai M, Inayama S, Hayashida H, Miyata T, Numa S (1983) Cloning and sequence analysis of cDNA for ovine corticotropin releasing factor precursor. Nature 301:537–540
Gainer H, Sarne Y, Brownstein M (1977) Biosynthesis and axonal transport of rat neurohypophyseal proteins and peptides. J Cell Biol 73:366–381
George JM (1978) Immunoreactive vasopressin and oxytocin: concentration in individual human hypothalamic nuclei. Science 200:342–343
Guldenaar SEF, Pickering BT (1985) Immunocytochemical evidence for the presence of oxytocin in rat testis. Cell Tissue Res 240:485–487
Horn AM, Robinson ICAF, Fink G (1985) Oxytocin and vasopressin in rat hypophyseal portal blood: experimental studies in normal and Brattleboro rats. J Endocrinol 104:211–224
Ivell R, Richter D (1984 a) The gene for the hypothalamic peptide hormone oxytocin is highly expressed in the bovine corpus luteum: biosynthesis, structure and sequence analysis. EMBO J 3:2351–2354
Ivell R, Richter D (1984 b) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci USA 81:2006–2010
Ivell R, Richter D (1985) The oxytocin gene and its expression in the hypothalamus and ovary. In: Amico JA, Robinson AG (eds) Oxytocin, clinical and laboratory studies. Elsevier Biomedical, Amsterdam, pp 115–123
Ivell R, Brackett K, Fields MJ, Richter D (1985) Ovulation triggers oxytocin gene expression in the bovine ovary. FEBS Lett 190:263–267
Land H, Schütz G, Schmale H, Richter D (1982) Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature 295:299–303
Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schütz G (1983) Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature 302:342–344
Leng G, Mason WT, Dyer R (1982) The supraoptic nucleus as an osmoreceptor. Neuroendocrinology 34:75–82
Majzoub JA, Rich A, van Boom J, Habener JF (1983) Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem 258:14061–14064
Makino T, Nakazawa K, Ishii K, Haginiwa I, Nakayama A, Iizuka R (1983) Detection of immunoreactive human placental oxytocin and its contractile effect on the uterine muscle. Endocrinol Jpn 30:389–395
Martin R, Voigt KH (1981) Enkephalins co-exist with oxytocin and vasopressin in nerve terminals of rat neurohypophysis. Nature 289:502–504
Maurer LH, O’Donnell JF, Kennedy S, Faulkner CS, Rist K, North WG (1983) Human neurophysins in carcinoma of the lung: relation to histology, disease stage, response rate, survival, and syndrome of inappropriate antidiuretic hormone secretion. Cancer Treat Rep 67:971–976
McCabe JT, Morrell JI, Richter D, Pfaff DW (1985) Localization of neuroendocrinologically relevant RNA in brain by in situ hybridization. Frontiers in neuroendocrinology 86
McKelvy JF (1975) Phosphorylation of neurosecretory granules by cAMP-stimulated protein kinase and its implications for transport and release of neurophysin proteins. Ann NY Acad Sci 248:80–91
Moore SEH, Hope DB (1985) High pressure liquid chromatography of bovine neurophysin isoforms. British Neuroendocrine Group inaugural meeting, 10–11 July 1985, Oxford, England, abstract 32
Nicholson HD, Swann RW, Burford GD, Wathes DC, Porter DG, Pickering BT (1984) Identification of oxytocin and vasopressin in the testis and in adrenal tissue. Regul Pept 8:141–146
North WG, Gellai M, Hardy G (1982) Oxytocin and oxytocin-associated neurophysin evaluated by RIA in the Brattleboro rat: turnover. Ann NY Acad Sci 394:167–172
Richter D (1983) Synthesis, processing and gene structure of vasopressin and oxytocin. Prog Nucl Acids Res Mol Biol 30:245–266
Ruppert S, Scherer G, Schütz G (1984) The primary structure of the bovine genes encoding the vasopressin and oxytocin precursor proteins reveals a recent gene conversion event. Nature 308:554–557
Russell JT, Brownstein MJ, Gainer H (1980) Biosynthesis of vasopressin, oxytocin and neurophysins: isolation and characterization of two common precursors (propresso- physin and pro-oxyphysin). Endocrinology 107:1880–1891
Sachs H, Fawcett P, Takabatake Y, Portanova R (1969) Biosynthesis and release of vasopressin and neurophysin. Rec Progr Horm Res 25:447–491
Schams D, Schallenberger E, Meyer HHD, Bullermann B, Breitinger H-J, Enzenhofer G, Koll R, Kruip TAM, Walters DL, Karg H (1985) Ovarian oxytocin during the estrous cycle in cattle. In: Amico JA, Robinson AG (eds) Oxytocin, clinical and laboratory studies. Elsevier Biomedical, Amsterdam, pp 317–334
Schmale H, Richter D (1980) In vitro biosynthesis and processing of composite common precursors containing amino acid sequences identified immunologically as neurophysin I/oxytocin and as neurophysin II/vasopressin. FEBS Lett 121:358–362
Schmale H, Richter D (1984) Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Nature 308:705–709
Schmale H, Leipold B, Richter D (1979) Cell-free translation of bovine hypothalamic mRNA: synthesis and processing of the prepro-neurophysin I and II. FEBS Lett 108:311–316
Schmale H, Ivell R, Breindl M, Darmer D, Richter D (1984) The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated. EMBO J 3:3289–3293
Sehöler J, Sladek JR (1981) Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input. Science 214:347–349
Sherman TG, McKelvy JF (1983) Cell-free biosynthesis of rat neurophysin polypeptides from poly(A)RNA isolated from individual hypothalamic nuclei. Neurosci Abstr 9:622
Sofroniev MV (1983) Morphology of vasopressin and oxytocin neurones and their central and vascular projections. In: The neurohypophysis: structure, function and control. Prog Brain Res 60:101–114
Sofroniev MV (1985) Vasopressin- and neurophysin-immunoreactive neurones in the septal region, medial amygdala and locus coeruleus in colchicine-treated rats. Neuroscience 15:347–358
Swann RW, Gonzalez CB, Birkett SD, Pickering BT (1982) Precursors in the biosynthesis of vasopressin and oxytocin in the rat. Biochem J 208:339–349
Swann RW, O’Shaughnessy PJ, Birkett SD, Wathes DC, Porter DG, Pickering BT (1984) Biosynthesis of oxytocin in the corpus luteum. FEBS Lett 174:262–266
Van Dyke HB, Chow BF, Greep RO, Rothen A (1942) Isolation of a protein from the ox pituitary with constant oxytocic, pressor and diuresis-inhibiting activities. J Pharmacol Exp Ther 74:190–209
Wathes DC, Swann RW (1982) Is oxytocin an ovarian hormone? Nature 297:225–227
Whitnall MH, Gainer H, Cox BM, Molineux CJ (1983) Dynorphin-A-(l-8) is contained within vasopressin neurosecretory vesicles in rat pituitary. Science 205:1137–1139
Wolfson B, Manning RW, Davis L, Arentzen R, Baldino F (1985) Co-localization of corticotropin releasing factor and vasopressin mRNA in neurons after adrenalectomy. Nature 315:59–61
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Ivell, R. (1986). Biosynthesis of Oxytocin in the Brain and Peripheral Organs. In: Ganten, D., Pfaff, D. (eds) Neurobiology of Oxytocin. Current Topics in Neuroendocrinology, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70414-7_1
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DOI: https://doi.org/10.1007/978-3-642-70414-7_1
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