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Pesticide—Drug Interaction in Rats

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Receptors and Other Targets for Toxic Substances

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 8))

Abstract

The possible interactions between a fungicide, thiram, and some drugs acting on the central nervous system were investigated in rats by means of behavioral methods. Potentiation was found after combined treatment with thiram and promethazine, and after thiram and meprobamate. In the case of trihexyphenidyl, an additive interaction was observed. It is presumed that these observations will be of practical toxicological significance.

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References

  • Candland DK, Campbell BA (1962) Development of fear in the rat as measured by behavior in the openfield. J. Comp. Physiol. Psychol. 55, 593–605.

    Article  Google Scholar 

  • Goldstein M (1966) Inhibition of norepinephrine biosynthesis at the dopamine-beta-hydroxylation stage. Pharmacol. Rev. 18, 77–82.

    PubMed  CAS  Google Scholar 

  • Lee CC, Peters PJ (1976) Neurotoxicity and behavioral effect of thiram in rats. Environ. Health Persp. 17, 35–43.

    Article  CAS  Google Scholar 

  • Maj J, Vetulani J (1970) Some pharmacological properties of N,N-disubstitued dithiocarbamates and their effect on the brain catecholamine levels. Eur. J. Pharmacol. 9, 183–189.

    Article  PubMed  CAS  Google Scholar 

  • Rothstein E (1968) Warfarin effect enhanced by disulfiram. J. Am. Med. Assoc. 206, 1574–1575.

    Article  CAS  Google Scholar 

  • Sharkawi M, Cianflone D (1978) Toxic interactions between disulfiram and some centrally acting drugs in rats. J. Pharm. Pharmac. 30, 63.

    Article  CAS  Google Scholar 

  • Thurânszky K, Kiss I, Botos M and Szebeni A (1982) Effect of dithiocarbamate-type chemicals on the nervous system of rats. Arch. Toxicol., Suppl. 5, 125–128.

    Article  Google Scholar 

  • Zemaitis MA, Greene FE (1976) Impairment of hepatic microsomal drug metabolism in the rat during daily disulfiram administration. Biochem. Pharmacol. 25, 453–459.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Hospital of County Council, H-8200, Veszprém, Hungary

    G. Fenyvesi

  2. Department of Toxicology, Research Institute for Heavy Chemical Industries, H-8200, Veszprém, Hungary

    M. Botos

  3. Department of Pharmacodynamics, University Medical School, H-6701, Szeged, Hungary

    J. Iván

Authors
  1. G. Fenyvesi
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  2. M. Botos
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  3. J. Iván
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Pharmacological Research Centre, Toxicological Service, Chemical Works of Gedeon Richter Ltd., P.O. Box 27, 1475, Budapest, Hungary

    Eszter Cholnoky

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© 1985 Springer-Verlag Berlin Heidelberg

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Fenyvesi, G., Botos, M., Iván, J. (1985). Pesticide—Drug Interaction in Rats. In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_40

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  • DOI: https://doi.org/10.1007/978-3-642-69928-3_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13670-5

  • Online ISBN: 978-3-642-69928-3

  • eBook Packages: Springer Book Archive

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