Abstract
Neurotoxic effect of some dithiocarbamate- and thiuram-disulphide-type chemicals as well as CS2 were examined on rat brain and behaviour. A significant reduction of the orientation hypermotility and at the same time a depression of the subcortical EEG activity were observed. The biochemical assay showed a decreased re-formation of norepinephrine. It is suggested that the inhibition of DBHenzyme may be involved in the delayed psychosedative effect, but not in the short-term electrophysiological changes.
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Abbreviations
- DTC:
-
dithiocarbamate
- Na-DEDC:
-
sodium-diethyldithiocarbamate
- DBH:
-
Dopamine-β-hydroxylase
- TMTD:
-
Thiram/tetramethylthiuramdisulphide
- DA:
-
dopamine
- p.o.:
-
orally
- i.p.:
-
intraperitoneally
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© 1982 Springer-Verlag
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Thuránszky, K., Kiss, I., Botos, M., Szebeni, A. (1982). Effect of Dithiocarbamate-Type Chemicals on the Nervous System of Rats. In: Chambers, C.M., Chambers, P.L. (eds) New Toxicology for Old. Archives of Toxicology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68511-8_23
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DOI: https://doi.org/10.1007/978-3-642-68511-8_23
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