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Chemotherapy of Tapeworm Infections in Man

  • Chapter
Chemotherapy of Gastrointestinal Helminths

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 77))

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Abstract

In the past 20 years, three new compounds, niclosamide, mebendazole, and praziquantel, have emerged to replace the innumerable organic and inorganic products and potions previously available for the treatment of human cestode infections. In terms of efficacy, safety, and ease of administration, they are far superior to their predecessors. The clinical use and chemistry of these older compounds (i.e., aspidium oleoresin, quinicrine, dichlorophen, and various tin, arsenical, lead, copper, and other inorganic elements) have been extensively reviewed, and, as they have been almost entirely replaced in human therapeutics, they will not be further examined here. While demonstrably better than our previous remedies for adult cestode infections, these three new compounds are not without their own problems in clinical use. Major advances in drug therapy for larval cestode infections in man have also been made, but much remains to be done before it reaches the effectiveness we currently can achieve with adult infections.

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  1. W. S. Kammerer
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Editors and Affiliations

  1. Department of Comparative Biochemistry, Research Laboratories, Janssen Pharmaceutica, Turnhoutseweg 30, 2340, Beerse, Belgium

    Hugo Vanden Bossche

  2. Department of Chemotherapy, Research Laboratories, Janssen Pharmaceutica, Turnhoutseweg 30, 2340, Beerse, Belgium

    Denis Thienpont

  3. Vogelsanck 12, 2232, Gravenwezel, Belgium

    Pieter G. Janssens

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Kammerer, W.S. (1985). Chemotherapy of Tapeworm Infections in Man. In: Bossche, H.V., Thienpont, D., Janssens, P.G. (eds) Chemotherapy of Gastrointestinal Helminths. Handbook of Experimental Pharmacology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69527-8_14

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