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History and Current Status of Drug Resistance

  • Chapter
Antimalarial Drugs I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 1))

Abstract

Biologists and physicians define drug resistance in different terms (Peters 1970 a), the former being more concerned with the parasite and the latter with the host. In this book the definition of WHO (1965) has been adopted. This states that, in malaria, resistance to drugs is the ability of the parasites to survive and/or multiply despite the administration and absorption of a drug given in doses equal to or higher than those usually recommended but within the limits of tolerance of the host. This definition points out that, while it may apply to any species or stage of malaria parasites, it is most commonly used with reference to the action of blood schizontocides, especially the 4-aminoquinolines when used in the treatment of infections with Plasmodium falciparum. This itself is a reflection of the serious impact made by the recognition of chloroquine resistance in P. falciparum in 1959 and 1960 since, in spite of the well-known problem of resistance to proguanil and pyrimethamine that had appeared in various parts of the world from 1949 onwards, no real attempt had been made to define the problem before 1963 (WHO 1963) and it was only in 1967 that a WHO Scientific Group established criteria by which the level of clinical response could be measured.

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  1. W. Peters
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Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Scientific Advisory Services, Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts., HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph.D. (Manager) (Manager)

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Peters, W. (1984). History and Current Status of Drug Resistance. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drugs I. Handbook of Experimental Pharmacology, vol 68 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69251-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-69251-2_16

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