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Antimalarial Drugs I

Biological Background, Experimental Methods, and Drug Resistance

  • Book
  • © 1984

Overview

Editors:
  1. Wallace Peters

    1. London School of Hygiene and Tropical Medicine, London, Great Britain

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    You can also search for this editor in PubMed   Google Scholar

  2. William H. G. Richards

    1. Scientific Advisory Services, Wellcome Research Laboratories, Berkhamsted, Herts., Great Britain

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 68 / 1)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XVIII
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  2. The Malaria Parasites

    1. Front Matter

      Pages 1-1
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    2. Life Cycles

      • P. C. C. Garnham
      Pages 3-30

    3. Metabolism

      • I. W. Sherman
      Pages 31-81

    4. In Vitro Culture Techniques

      • W. H. G. Richards
      Pages 83-98

  3. Host Responses to Malaria

    1. Front Matter

      Pages 99-99
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    2. Immunity

      • G. H. Mitchell
      Pages 101-125

    3. Clinical Pathology

      • V. Boonpucknavig, T. Srichaikul, S. Punyagupta
      Pages 127-176

  4. Experimental Models

    1. Front Matter

      Pages 177-177
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    2. In Vitro Techniques for Antimalarial Development and Evaluation

      • R. E. Desjardins
      Pages 179-205

    3. Use of Avian Malarias (In Vivo)

      • W. H. G. Richards
      Pages 207-224

    4. Rodent Malaria Models

      • A. L. Ager Jr.
      Pages 225-264

    5. Malaria Models in Simian Hosts

      • R. N. Rossan
      Pages 265-280

    6. Surrogate Models for Antimalarials

      • S.-C. Chou, K. A. Conklin, M. R. Levy, D. C. Warhurst
      Pages 281-329

    7. Interactions Between Chemotherapy and Immunity

      • G. A. T. Targett
      Pages 331-348

  5. Preclinical and Clinical Trial Techniques

    1. Front Matter

      Pages 349-349
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    2. Preclinical Testing

      • M. H. Heiffer, D. E. Davidson Jr., D. W. Korte Jr.
      Pages 351-373

    3. Clinical Trials — Phases I and II

      • M. Fernex
      Pages 375-397

    4. Clinical Trials — Phases III and IV and Field Trials

      • M. Fernex
      Pages 399-410

    5. Pharmacogenetic Factors in Antimalarial Drug Testing

      • H. M. Gilles
      Pages 411-420
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Keywords

About this book

Of all the parasitic diseases that beset man in the warmer parts of the world, malaria is still the major cause of morbidity and mortality. In spite of intensive efforts to interrrupt its transmission malaria still threatens over 800 million people, more than one-fifth of the world's population. Malignant tertian malaria caused by Plasmodium Jalciparum probably kills a million every year. Vivax malaria temporarily incapacitates millions more. The search for antimalarial drugs, both natural and syn. thetic, has been and continues to be one of the most challenging and, at times, rewarding exercises ever undertaken by ;:;hemists and biologists. The magnitude of the effort is reflected by the fact that, in the last 15 years, well over 250000 compounds have been screened for antimalarial activity in just one programme, that carried out under the auspices of the Walter Reed Army Institute of Research, not to mention sporadic studies undertaken by other research workers and organisations. While most people engaged in the search for new drugs agree that a rational approach based on knowledge of the intimate biochemical pathways of the target cells would be ideal as well as intellectually satisfying, most are reluctantly obliged to concede that, up to the present time, the chances of success following a more or less empirical search have been far greater. Spectacular advances in molecular biology and biochemistry in recent years, however, are rapidly changing this situation.

Editors and Affiliations

  • London School of Hygiene and Tropical Medicine, London, Great Britain

    Wallace Peters

  • Scientific Advisory Services, Wellcome Research Laboratories, Berkhamsted, Herts., Great Britain

    William H. G. Richards

Bibliographic Information

  • Book Title: Antimalarial Drugs I

  • Book Subtitle: Biological Background, Experimental Methods, and Drug Resistance

  • Editors: Wallace Peters, William H. G. Richards

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-69251-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1984

  • Softcover ISBN: 978-3-642-69253-6Published: 19 November 2011

  • eBook ISBN: 978-3-642-69251-2Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVIII, 484

  • Topics: Pharmacology/Toxicology, Medical Microbiology, Pharmacy

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