Abstract
The first classical animal experiment in endocrinology was carried out in Göttingen in 1849 by the physiologist A.A. Berthold. He castrated roosters and observed a clear-cut inhibition of comb growth, of male plumage and particularly of male sexual behaviour. The capons did not crow any more and also showed decreased aggressiveness. The crucial animal experiment was the implantation of testes in the abdominal cavity, which prevented these changes and even reversed them. From this it was concluded that testes could secrete a substance into the blood which prevented and even reversed the somatic and behavioural consequences of castration (Berthold 1849).
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Dörner, G. (1983). Hormone-Dependent Brain Development and Behaviour. In: Balthazart, J., Pröve, E., Gilles, R. (eds) Hormones and Behaviour in Higher Vertebrates. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69216-1_14
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DOI: https://doi.org/10.1007/978-3-642-69216-1_14
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