Skip to main content

Hormone-Dependent Brain Development and Behaviour

  • Conference paper
Hormones and Behaviour in Higher Vertebrates

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The first classical animal experiment in endocrinology was carried out in Göttingen in 1849 by the physiologist A.A. Berthold. He castrated roosters and observed a clear-cut inhibition of comb growth, of male plumage and particularly of male sexual behaviour. The capons did not crow any more and also showed decreased aggressiveness. The crucial animal experiment was the implantation of testes in the abdominal cavity, which prevented these changes and even reversed them. From this it was concluded that testes could secrete a substance into the blood which prevented and even reversed the somatic and behavioural consequences of castration (Berthold 1849).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bartholomé K (1980) Die molekulare Basis der Heterogenität der Phenylketonurie. Naturwissenschaften 67: 495–498

    Article  PubMed  Google Scholar 

  • Bell AP, Weinberg MS, Hammersmith SK (1980) Der Kinsey Institut Report über sexuelle Orientierung und Partnerwahl. Bertelsmann, München

    Google Scholar 

  • Berthold AA (1849) Transplantation der Hoden. Arch Anat Physiol Wiss Med 42–46

    Google Scholar 

  • Bubenik GA, Brown GM (1973) Morphologic sex differences in primate brain areas involved in regulation of reproductive activity. Experientia 29: 619–621

    Article  PubMed  CAS  Google Scholar 

  • Dantchakoff V (1938) Rôle des hormones dans les manifestations des instincts sexuel. C R Acad Sci 206: 945–947

    Google Scholar 

  • Döcke F, Dörner G (1966) Tierexperimentelle Untersuchungen zur Ovulationsauslösung mit Gonadotropinen und Östrogenen. 4. Mitt. Zur neurohormonalen Regulation der Ovulation. Zentralbl Gynaekol 88: 273–282

    Google Scholar 

  • Dörner G (1972) Sexualhormonabhängige Gehirndifferenzierung und Sexualität. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Dörner G (1976) Hormones and brain differentiation. Elsevier, Amsterdam Oxford New York

    Google Scholar 

  • Dörner G (1980) Sexual differentiation of the brain. In: Munson PL, Diczfalusy E, Glover J, Olson RE (eds) Vitamins and hormones, vol XXXVIII. Academic Press, London New York

    Google Scholar 

  • Dörner G, Döcke F (1964) Sex-specific reaction of the hypothalamo-hypophysial system of rats. J Endocrinol30: 265–266

    Google Scholar 

  • Dörner G, Grychtolik H (1973) Zur Bedeutung frühpostnataler Umwelteinflüsse für die spätpostnatale Lernfähigkeit von Kindern. Acta Biol Med Ger 31: 53–56

    Google Scholar 

  • Dörner G, Grychtolik H (1978) Long-lasting ill-effects of neonatal qualitative and/or quantitative dysnutrition in the human. Endokrinologie 71: 81–88

    PubMed  Google Scholar 

  • Dörner G, Staudt J (1969) Structural changes in the hypothalamic ventromedial nucleus of the male rat, following neonatal castration and androgen treatment. Neuroendocrinology 4: 278–281

    Article  PubMed  Google Scholar 

  • Dörner G, Staudt J (1972) Vergleichende morphologische Untersuchungen der Hypóthalamusdifferenzierung bei Ratte und Mensch. Endokrinologie 59: 152–155

    PubMed  Google Scholar 

  • Dörner G, Döcke F, Moustafa S (1968) Differential localization of a male and a female hypothalamic mating centre. J Reprod Fertil 17: 583–586

    Article  PubMed  Google Scholar 

  • Dörner G, Rohde W, Baumgarten G (1971) Bestimmung des genetischen Geschlechts des Foeten durch fluoreszenzmikroskopischen Nachweis des Y-Chromosoms in Fruchtwasserzellen. Acta Biol Med Ger 26: 1095–1098

    PubMed  Google Scholar 

  • Dörner G, Stahl F, Baumgarten G (1972) Signifikante Unterschiede im Testosteron-und 11OHCS-Gehalt des Fruchtwassers zwischen männlichen und weiblichen Foeten. Endokrinologie 60: 285–298

    PubMed  Google Scholar 

  • Dörner G, Götz F, Rohde W (1975a) On the evocability of a positive oestrogen feedback action on LH secretion in male and female rats. Endokrinologie 66: 369–372

    PubMed  Google Scholar 

  • Dörner G, Rohde W, Stahl F, Krell L, Masius WG (1975b) A neuroendocrine predisposition for homosexuality in men. Arch Sex Behav 4: 1–8

    Article  PubMed  Google Scholar 

  • Dörner G, Hecht K, Hinz G (1976) Teratopsychogenetic effects apparently produced by non-physiological neurotransmitter concentrations during brain differentiation. Endokrinologie 68: 1–5

    PubMed  Google Scholar 

  • Dörner G, Stahl F, Rohde W, Göretzlehner G, Witkowski R, Saffert H (1977a) Sex-specific testosterone and FSH concentrations in amniotic fluids of mid-pregnancy. Endokrinologie 70: 86–88

    PubMed  Google Scholar 

  • Dörner G, Staudt J, Wenzel J, Kvetnanskÿ R, Murgas K (1977b) Further evidence of teratogenic effects apparently produced by neurotransmitters during brain differentiation. Endokrinologie: 70: 326–330

    PubMed  Google Scholar 

  • Dörner G, Geier T, Ahrens L, Krell L, Münx G, Sieler H, Kittner E, Müller H (1980) Prenatal stress as possible aetiogenetic factor of homosexuality in human males. Endokrinologie 75: 365 368

    Google Scholar 

  • Dörner G, Tönjes R, Hecht K, Hinz G, Poppe I, Poppei M, Tsamaloukas A (1981) Pyridostigmine administration in newborn rats prevents mental ill-effects produced by maternal deprivation. Endokrinologie 77: 101–104

    PubMed  Google Scholar 

  • Dörner G, Götz F, Döcke WD (1983a) Prevention of demasculinization and feminization of the brain in prenatally stressed male rats by perinatal androgen treatment. Exp Clin Endocrinol 81: 88–90

    Article  PubMed  Google Scholar 

  • Dörner G, Schenk B, Schmiedel B, Ahrens L (1983b) Stressful events in prenatal life of bi-and homosexual men. Exp Clin Endocrinol 81: 83–87

    Article  PubMed  Google Scholar 

  • Dörner G, Bluth R, Tönjes R (1983c) Acetylcholine concentrations in the developing brain appear to affect emotionality and mental capacity in later life. Acta Biol Med Ger 41: 721–723

    Google Scholar 

  • Gaziri LCJ, Ladosky W (1973) Monoamine oxidase variation during sexual differentiation. Neuroendocrinology 12: 249–256

    Article  PubMed  CAS  Google Scholar 

  • Götz F, Dörner G (1975) The influence of the gonads on the maturation of hypothalamic sex and mating centres in the rat. Acta Endocrinol Suppl 199: 143

    Google Scholar 

  • Götz F, Dörner G (1980) Homosexual behaviour in prenatally stressed male rats after castration and oestrogen treatment in adulthood. Endokrinologie 76: 115–117

    PubMed  Google Scholar 

  • Götz F, Dörner G (1980) Homosexual behaviour in prenatally stressed male rats after castration and oestrogen treatment in adulthood. Endokrinologie 76: 115–117

    PubMed  Google Scholar 

  • Gorski RA, Harlan RE, Christensen LW (1977) Perinatal hormonal exposure and the development of neuroendocrine regulatory processes. J Toxicol Environ Health 3: 97–121

    Article  PubMed  CAS  Google Scholar 

  • Imperato-McGinley J, Peterson RE, Goutier I, Sturla E (1979) Male pseudohermaphroditism secondary to 50-reductase deficiency — a model for the role of androgens in both the development of the male phenotype and the evolution of a male gender identity. J Steroid Biochem 11: 637–645

    Article  PubMed  CAS  Google Scholar 

  • Ladosky W, Gaziri LCJ (1970) Brain serotonin and sexual differentiation of the nervous system. Neuroendocrinology 6: 168–174

    Article  PubMed  CAS  Google Scholar 

  • Money J, Schwartz M (1977) Dating, romantic and nonromantic friendships, and sexuality in 17 early-treated adrenogenital females, aged 16–25: In: Lee PA, Plotnick LP, Kowarski AA, Migeon CJ (eds) Congenital adrenal hyperplasia. Univ Park Press, Baltimore, pp 419–431

    Google Scholar 

  • Myers RE (1979) Maternal anxiety and fetal death. In: Zichella L, Pancheri P (eds) Psychoneuroendocrinology in reproduction. Elsevier/North-Holland Biomed Press, Amsterdam New York Oxford, pp 555–573

    Google Scholar 

  • Nottebohm F, Arnold AP (1976) Sexual dimorphism in vocal control areas of the song-bird brain. Science 194: 211–213

    Article  PubMed  CAS  Google Scholar 

  • Pfeiffer CA (1936) Sexual differences of the hypophyses and their determination by the gonads. Am J Anat 58: 195–225

    Article  Google Scholar 

  • Phoenix CH, Goy RW, GeIallAA, Young WC (1959) Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65: 369–382

    Article  PubMed  CAS  Google Scholar 

  • Raisman G, Field PM (1973) Sexual dimorphism in the neuropil of the preoptic area of the rat and its dependence on neonatal androgen. Brain Res 54: 1–29

    Article  PubMed  CAS  Google Scholar 

  • Rodgers B (1978) Feeding in infancy and later ability and attainment: a longitudinal study. Dev Med Child Neurol 20: 421–426

    Article  PubMed  CAS  Google Scholar 

  • Rodgers B (1978) Feeding in infancy and later ability and attainment: a longitudinal study. Dev Med Child Neurol 20: 421–426

    Article  PubMed  CAS  Google Scholar 

  • Stahl F, Götz F, Poppe I, Amendt P, Dörner G (1978) Pre-and early postnatal testosterone levels in rat and human. In: Dörner G, Kawakami M (eds) Hormones and brain development. Elsevier/North-Holland Biomedical Press, Amsterdam New York Oxford, pp 99–109

    Google Scholar 

  • Staudt J, Stüber P, Dörner G (1978) Permanent changes of sexual dimorphism in the rat brain following neonatal treatment with psychotrophic drugs. In: Dörner G, Kawakami M (eds) Hormones and brain development. Elsevier/North-Holland Biomed Press, Amsterdam New York Oxford, pp 35–41

    Google Scholar 

  • Wagner R (1853) Handwörterbuch der Physiologie mit Rücksicht auf physiologische Pathologie, Vol IV. Braunschweig

    Google Scholar 

  • Ward IL (1977) Exogenous androgen activates female behavior in non-copulating, prenatally stressed male rats. J Comp Physiol Psychol 91: 465–471

    Article  PubMed  CAS  Google Scholar 

  • Waxenberg SE, Drellich MG, Sutherland AM (1959) Changes in female sexuality after adrenalectomy. J Clin Endocrinol Metab 19: 193–202

    Article  PubMed  CAS  Google Scholar 

  • Wurtman RJ, Growdon JH (1979) Dietary control of central cholinergic activity. In: Davis KL, Berger PA (eds) Brain acetylcholine and neuropsychiatric disease. Plenum Press, New York, pp 461–481

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Dörner, G. (1983). Hormone-Dependent Brain Development and Behaviour. In: Balthazart, J., Pröve, E., Gilles, R. (eds) Hormones and Behaviour in Higher Vertebrates. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69216-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69216-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69218-5

  • Online ISBN: 978-3-642-69216-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics