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Dietary Control of Central Cholinergic Activity

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Brain Acetylcholine and Neuropsychiatric Disease

Abstract

This chapter describes the relationship between choline — administered as choline chloride or as phosphatidylcholine (lecithin), by injection or via the diet — and tissue acetylcholine (ACh) levels, and shows that choline administration, by raising blood and brain choline levels, can be a major determinant of the rate of ACh synthesis and, probably, of the amount of the neurotransmitter released when cholinergic neurons are depolarized.

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Author information

Authors and Affiliations

  1. Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    R. J. Wurtman & J. H. Growdon

  2. Department of Neurology, Tufts University Medical School, Boston, Massachusetts, 02111, USA

    J. H. Growdon

Authors
  1. R. J. Wurtman
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  2. J. H. Growdon
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Editor information

Editors and Affiliations

  1. Veterans Administration Hospital, Palo Alto, California, 94304, USA

    Kenneth L. Davis  & Philip A. Berger  & 

  2. Stanford University School of Medicine, Stanford, California, 94305, USA

    Kenneth L. Davis  & Philip A. Berger  & 

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© 1979 Plenum Press, New York

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Wurtman, R.J., Growdon, J.H. (1979). Dietary Control of Central Cholinergic Activity. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_27

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  • DOI: https://doi.org/10.1007/978-1-4613-2934-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2936-7

  • Online ISBN: 978-1-4613-2934-3

  • eBook Packages: Springer Book Archive

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