Abstract
In previous work on the cellular effects of cannabis it was observed that an increase occurred in the glucose metabolism in post mitochondrial fraction of the liver of rats submitted to chronic treatment with cannabis extracts. In this paper, the results obtained with acute treatment are shown. A single dose of cannabis extract (600 mg/kg) in olive oil was administered to male adult rats and the animals were killed within a 36-h period. Energetic and detoxifying metabolism of glucose are increased as shown by the increase of F-1, 6-di P-aldolase and UDPG-DH activities which parallel the observed decrease of glycogen levels. Maximum effect appears between 8 and 16 h after the administration.
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Abbreviations
- F-1,6-di P-aldolase:
-
fructose-1,6-diphosphate aldolase
- p. m. f.:
-
post-mitochondrial fraction
- s. c.:
-
subcutaneously
- UDPG-DH:
-
uridine diphosphoglucose dehydrogenase
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© 1983 Springer-Verlag
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Sanz, P., Rodríguez-Vicente, C., Repetto, M. (1983). Alteration of Glucose Liver Metabolism by Acute Treatment with Cannabis. In: Chambers, C.M., Chambers, P.L., Gitter, S. (eds) Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals. Archives of Toxicology, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69083-9_21
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DOI: https://doi.org/10.1007/978-3-642-69083-9_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12392-7
Online ISBN: 978-3-642-69083-9
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