Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals

Proceedings of the European Society of Toxicology Meeting, Held in Tel Aviv, March 21–24, 1982

  • Claire M. Chambers
  • Philip L. Chambers
  • S. Gitter

Part of the Archives of Toxicology book series (TOXICOLOGY, volume 6)

Table of contents

  1. Front Matter
    Pages I-X
  2. Effects of Foreign Substances on Blood

    1. Front Matter
      Pages 1-1
    2. Dina Meytes, B. Ramot
      Pages 13-20
    3. A. Cerrati, G. Bruno, C. Casarotto, A. Mariani, I. Raggi, A. Ronzio et al.
      Pages 47-47
  3. Drugs of Abuse — With Special Reference to Marijuana and Phencyclidine

    1. Front Matter
      Pages 59-59
    2. R. Mechoulam, N. Lander, S. Dikstein, B. Shalita
      Pages 104-104
    3. M. Cais, S. Dani, M. Shimoni
      Pages 105-113
    4. E. Malizia, S. Borgo, G. Andreucci, M. Smeriglio
      Pages 114-114
    5. P. Sanz, P. Villar, M. Repetto
      Pages 115-120

About these proceedings

Introduction

Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980).

Keywords

Cannabinoid Ethanol Interferon Toxicology Toxikologie drugs of abuse marijuana mercury pesticide

Editors and affiliations

  • Claire M. Chambers
    • 1
  • Philip L. Chambers
    • 1
  • S. Gitter
    • 2
  1. 1.Department of Pharmacology, Trinity CollegeUniversity of DublinDublin 2Ireland
  2. 2.Sackler Faculty of Medicine, and Kupat Holim — General Federation of LabourInstitute for Occupational Health, Tel Aviv UniversityTel AvivIsrael

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69083-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-12392-7
  • Online ISBN 978-3-642-69083-9
  • Series Print ISSN 0171-9750
  • About this book