Abstract
We would be remiss to conclude this issue in immunodermatology without discussing the role of the Langerhans cells (LC) in dermatological processes. These cells, described by Paul Langerhans in 1868, have recently been found to be antigen-presenting during the induction of contact-allergic reactions [9,10,11,12,14]. UVB light (290–320 nm) has been reported to diminish the density of murine epidermal LCs as determined by staining for membrane ATPase [4, 16] and to prevent the induction of contact sensitization to DNCB [4]. Conclusions with respect to the role of LCs in these experiments are difficult to draw in the light of observations that even spleen cells from such UV irradiated mice are unable to present antigens effectively [6]. It was therefore of great interest to ascertain whether other physicochemical agents also have an effect on the number of functions of epidermal LCs.
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© 1983 Springer-Verlag Berlin Heidelberg
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Gigli, I. (1983). Conclusions. In: Gigli, I.N., Miescher, P.A., Müller-Eberhard, H.J. (eds) Immunodermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68702-0_15
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DOI: https://doi.org/10.1007/978-3-642-68702-0_15
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