Abstract
Patients with cardiomyopathy often receive multiple medicines, including digitalis, diuretics, antiarrhythmic agents, and vasodilators. Digitalis pharmacokinetics are altered by several of these drugs and these interactions are important. In the past few years the pharmacokinetic interaction of digoxin with quinidine has been discovered and there has been considerable progress in understanding the mechanism of this interaction. In addition, interaction of digoxin with amiodarone and with verapamil has been reported. Spironolactone has been shown to increase serum digoxin levels. Finally, there is data on an interaction between digitalis and vasodilator drugs.
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© 1983 Springer-Verlag Berlin Heidelberg
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Marcus, F.I. (1983). Interaction Between Digoxin and Antiarrhythmic, Diuretic, or Vasodilator Drugs. In: Just, H., Schuster, H.P. (eds) Myocarditis Cardiomyopathy. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68608-5_26
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DOI: https://doi.org/10.1007/978-3-642-68608-5_26
Publisher Name: Springer, Berlin, Heidelberg
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