Skip to main content
SpringerLink
Log in

Retinoid-Stimulated Material in Psoriatic Epidermis During Ro 10-9359 Therapy

  • Conference paper
Retinoids

Abstract

Cell surface molecules modulate the cell-to-cell interactions which may control cell proliferation. Psoriasis is a disease in which abnormal epidermal cell interactions may play a pertinent role (13). Retinoids, which are known to be effective in psoriasis therapy, exert profound effects on squamous epithelia in cell culture and in vivo as manifested by mucous metaplasia and alterations in cell proliferation (10). Whether these biological effects are the result of differences in cell interactions induced by retinoids is unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bellows CG, Hardy MH (1977) Histochemical evidence of mucosubstances in the metaplastic epidermis and hair follicles produced in vitro in the presence of excess vitamin A. Anat Rec 18: 257–272

    Article  Google Scholar 

  2. Bundino S, Zina AM (1980) Disseminated porokeratosis Mibelli treated with Ro 10-9359. Dermatologica 160: 328–336

    Article  PubMed  CAS  Google Scholar 

  3. Diaz LA (1979) Molecular structure of the epidermal extracellular spaces. Int J Dermatol 18: 434–442

    Article  PubMed  CAS  Google Scholar 

  4. Hardy MH, Sweeny PR, Bellows CG (1978) The effects of vitamin A on the epidermis of the fetal mouse in organ culture–an ultrastructural study. J Ultrastruct Res 64: 246–260

    Article  PubMed  CAS  Google Scholar 

  5. Kimura S (1977) Composition and mechanism of deposition of the intercellular substance in parakeratotic psoriatic epidermis. J Dermatol (Tokyo) 4: 179–185

    CAS  Google Scholar 

  6. Kimura S, Nishikawa T (1978) An immunohistochemical analysis of the deposited immunoglobnlins of fibrinogen in parakeratotic psoriatic horny layer and pemphigus skin lesions. Arch Dermatol Res 261: 55–62

    Article  PubMed  CAS  Google Scholar 

  7. Kimura S, Nishikawa T (1980) A further study on the mechanism of deposition of plasma protein in psoriasis scale. Arch Dermatol Res 268: 79–84

    Article  PubMed  CAS  Google Scholar 

  8. Krogh HK, Tonder 0 (1973) Antibodies in psoriatic scales. Scand J Immunol 2: 45–51

    Article  CAS  Google Scholar 

  9. Matter A, Bollag W (1977) A fine structural study on the therapeutic effect of an aromatic retinoid on chemically-induced skin papilloma of the mouse. Eur J Cancer 13: 831–838

    PubMed  CAS  Google Scholar 

  10. Mayer H, Bollag W, Hänni R, Ruegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34: 1105–1119

    Article  PubMed  CAS  Google Scholar 

  11. Nagy-Vezekényi C, Zs-Nagy I (1971) Studies on the ultrastructure of psoriasis and of the “normal” skin of psoriatics. Acta Derm Vener (Stockh) 51: 435–443

    Google Scholar 

  12. Orfanos CE, Runne U (1978) Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 157 (Suppl. 1): 19–25

    Article  PubMed  Google Scholar 

  13. Orfanos CE, Schaumburg-Lever G, Mahrle G, Lever WF (1973) Alterations of cell surfaces as a pathogenetic factor in psoriasis. Arch Dermatol 107: 38–46

    Article  PubMed  CAS  Google Scholar 

  14. Peck GL, Elias PM, Wetzel B (1977) Effects of retinoic acid on embryonic chick skin. J Invest Dermatol 69: 463–476

    Article  PubMed  CAS  Google Scholar 

  15. Prutkin L (1975) Mucus metaplasia and gap junctions in the vitamin A acid-treated skin tumor, keratoacanthoma. Cancer Res 35: 364–369

    PubMed  CAS  Google Scholar 

  16. Sagami S, Kitano Y (1970) Electron microscopic study of the effect of vitamin A on the differentiation of reconstructed embryonic chick skin. Br J Dermatol 83: 565–571

    Article  PubMed  CAS  Google Scholar 

  17. Tsambaos D, Mahrle G, Orfanos CE (1980) Epidermal changes induced by oral excess of aromatic retinoid in guinea pigs. Arch Dermatol Res 267: 141–152

    Article  PubMed  CAS  Google Scholar 

  18. Wilkoff LJ, Peckham JC, Dulmadge EA, Mowry RW, Chopra DP (1976) Evaluation of vitamin A analogs in modulating epithelial differentiation of 13-day chick embryo metatarsal skin explants. Cancer Res 36: 964–972

    PubMed  CAS  Google Scholar 

  19. Wong YC (1975) Mucous metaplasia of the hamster check pouch epithelium under hypervitaminosis A. Exp Mol Pathol 23: 132–143

    Article  PubMed  CAS  Google Scholar 

  20. Williams ML, Elias PM (1980) The pathogenesis of skin fragility from systemic retinoids is epidermal in origin. Clin Res 28: 585A (Abstract)

    Google Scholar 

Download references

Authors
  1. Ch. N. Ellis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. C. Gold
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. C. Grekin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. A. Swanson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Th. F. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. J. Voorhees
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, West Germany

    C. E. Orfanos (Director) (Director)

  2. Universitäts-Hautklinik, Frauenlobstraße 9, D-8000, München 2, West Germany

    O. Braun-Falco M.D. (Chairman) (Chairman)

  3. Department of Dermatology, Stanford University School of Medicine, 94305, Stanford, California, USA

    E. M. Farber M.D. (Chairman) (Chairman)

  4. 38, Reu de Courcelles, F-75008, Paris, France

    Ch. Grupper M.D.

  5. NL-2361 BV, Postdam 7, Warmond, Netherlands

    M. K. Polano M.D.

  6. Dermatologische Universitätsklinik, Kantonsspital Basel, Petersgraben 4, CH-4031, Basel, Switzerland

    R. Schuppli M.D. (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag

About this paper

Cite this paper

Ellis, C.N., Gold, R.C., Grekin, R.C., Swanson, N.A., Anderson, T.F., Voorhees, J.J. (1981). Retinoid-Stimulated Material in Psoriatic Epidermis During Ro 10-9359 Therapy. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68023-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68025-0

  • Online ISBN: 978-3-642-68023-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation