Abstract
Aplastic anaemia is characterised by pancytopenia with profound bone marrow hypoplasia. This is associated with a reduced number of granulocyte precursor cells (CFU-C) in the bone marrow [6, 2]. While the end-result of a variety of processes may produce this apparent stem cell failure in aplastic anaemia, an immunological mechanism may be responsible in at least some patients [3, 1, 5].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ascensão, J., Pahwa, R., Kagan, W., Hansen, J., Moore, M. A. S. and Good, R.: Aplastic anaemia: Evidence for an immunological mechanism. Lancet I, 669 (1976)
Barrett, A. J., Faille, A., Balitrand, N., Ketels, F. and Gluckman, E.: Granulocyte colony culture in aplastic anaemia. J. Clin. Path. 32, 660–665 (1979)
Benestadt, H. B.: Aplastic anaemia: Consideration on the pathogenesis. Acta Medica Scand. 196, 255–262 (1974)
Boyum, A.: Separation of leucocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21, Suppl 97, 77–89 (1968)
Kagan, W. A., Ascensão, J. A., Pahwa, N., Hansen, J. A., Goldstein, G., Valera, E. B., Incefy, G. S., Moore, M. A. S. and Good, R. A.: Aplastic anaemia: Presence in human bone marrow of cells that suppress myelopoiesis. Proceeding of the National Academy of Sciences 73, 2890–2894 (1976)
Kern, P., Heimpel, H., Heit, W. and Kubanek, B.: Granulocytic progenitor cells in aplastic anaemia. Brit. J. Haem. (1977)
Pike, B. L. and Robinson, W. A.: Human bone marrow colony growth in agar gel. J. of Cellular Physiology 76–77 (1970)
Royal Marsden Hospital Bone Marrow Transplantation Team: Failure of syngeneic bone marrow graft without pre-conditioning in post-hepatitis marrow aplasia. Lancet II, 742 (1977)
Storb, R., Thomas, E. D., Weiden, P. L., Dean Buckner, C., Clift, R. A., Fefer, A., Fernando, L. P., Giblett, E. R., Goodell, B. W., Johnson, F. L., Lerner, K. G., Neiman, P. E. and Sander, J. E.: Aplastic anaemia treated by allogeneic bone marrow transplantation: A report on 49 new cases from Seattle. Blood 48, 817–841 (1976)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Barrett, A.J., Faille, A. (1979). Serum Inhibitors of Granulocyte CFU-C in Aplastic Anaemia. In: Heimpel, H., Gordon-Smith, E.C., Heit, W., Kubanek, B. (eds) Aplastic Anemia. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67483-9_30
Download citation
DOI: https://doi.org/10.1007/978-3-642-67483-9_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09772-3
Online ISBN: 978-3-642-67483-9
eBook Packages: Springer Book Archive