Aplastic Anemia

Pathophysiology and Approaches to Therapy

  • Hermann Heimpel
  • Edward C. Gordon-Smith
  • Wolfgang Heit
  • Bernhard Kubanek

Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 24)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. H. Heimpel
      Pages 3-5
  3. Clinical Observations in Aplastic Anemia

    1. Front Matter
      Pages 7-7
    2. E. C. Gordon-Smith
      Pages 9-13
    3. L. E. Böttiger
      Pages 27-37
    4. K. P. Hellriegel, I. Fohlmeister, H. E. Schaefer
      Pages 47-51
    5. B. M. Camitta, E. C. Gordon-Smith
      Pages 53-56
  4. Kinetics and Control of Hemopoietic Stem Cells

    1. Front Matter
      Pages 57-57
    2. A. Mangalik, W. A. Robinson, R. Bolin, Asha Mangalik, Maureen Entringer
      Pages 87-95
    3. M. A. S. Moore, N. S. Wickramasinghe
      Pages 123-126
  5. The Rationale of Therapeutic Approaches in Aplastic Anemia

    1. Front Matter
      Pages 127-127
    2. G. Lucarelli, T. Izzi, A. Porcellini, C. Delfini
      Pages 167-170
    3. E. Gluckman, A. Devergie, A. Faille, A. Bussel, M. Benbunan, J. Bernard
      Pages 171-179
    4. B. Netzel, R. J. Haas, M. Helmig, H. Rodt, E. Thiel, B. Belohradsky et al.
      Pages 181-191
    5. L. J. M. Sabbe, H. L. Haak, B. A. Bradley, J. J. van Rood
      Pages 199-207
    6. R. K. Shadduck, A. Winkelstein, Z. Zeigler, J. Lichter, M. Goldstein, M. Michaels et al.
      Pages 209-217
  6. Problems of an Immunological Pathogenesis in Aplastic Anemia

    1. Front Matter
      Pages 219-219
    2. R. P. Gale, R. Mitsuyasu, Coralee Yale
      Pages 229-236
    3. A. J. Barrett, A. Faille
      Pages 237-246
    4. M. Y. Gordon
      Pages 247-254
    5. H. L. Haak, H. M. Goselink, L. Sabbe, W. F. J. Veenhof, A. J. J. C. Bogers, J. L. M. Waayer
      Pages 259-264
    6. S. Thierfelder, E. Thorsby
      Pages 277-279
  7. Final Discussion

    1. Front Matter
      Pages 281-281
    2. H. Heimpel, M. A. S. Moore
      Pages 283-288
  8. Summing-up

    1. Front Matter
      Pages 289-289
    2. E. C. Gordon-Smith
      Pages 291-292
  9. Back Matter
    Pages 293-294

About this book


Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology. New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell system .opened a new area of scientific interest for this "prototype" of haemopoietic failure. In addition, bone marrow transplantation became not only a clinical method of treatment, but also a source of data useful for the discussion of pathophysiological models of aplastic anaemia. This situation prompted us to arrange an international con­ ference on aplastic anaemia, with particular emphasis on its patho­ physiology and the rationals of the current therapeutic approaches. This conference was held at Schloss Reisensburg from July 20-22, 1978 with the participation of both experimental and clinical scientists active in this field or in related areas of research. The proceedings of the symposion reflect the present knowledge as well as the many new questions which arose from the discussions. The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni­ versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors who provided the financial basis for this scientific event.


Aplastische Anämie bone cells pathophysiology physiology therapy

Editors and affiliations

  • Hermann Heimpel
    • 1
  • Edward C. Gordon-Smith
    • 2
  • Wolfgang Heit
    • 1
  • Bernhard Kubanek
    • 1
  1. 1.Department Innere MedizinAbteilung Innere Medizin und HämatologieUlmFederal Republic of Germany
  2. 2.Department of Haematology, Royal Postgraduate Medical SchoolHammersmith HospitalLondon W12Great Britain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-09772-3
  • Online ISBN 978-3-642-67483-9
  • Series Print ISSN 0440-0607
  • Buy this book on publisher's site