Skip to main content
SpringerLink
Log in

Effect of Adrenergic Blockade on Cerebral Ischemia

  • Conference paper
Brain and Heart Infarct II

Abstract

Animal models, which simulate cerebral blood flow disturbances, are commonly used in modern pharmacology (6, 25). In the past 5 years, our group has intensively studied the problems of CNS ischemia, using mainly two types of models: the oligemia model in cats (incomplete ischemia) and the model of temporary ischemia in the isolated perfused rat head (complete ischemia). Besides vasoactive substances, which proved to be without any protective action on the ischemically disturbed brain (10, 11, 14, 39), we tested different drugs acting on the monoaminergic system. In the present study, a barbiturate (pentobarbital/ Nembutal) was compared with the ergot compound DH ergotoxine. Both drugs are known to exert specific effects on the monoaminergic system of the CNS.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andjus, R.K., Suhara, K., Sloviter, H.A.J.: J. Appl. Physiol. 22, 1033–1039 (1967)

    PubMed  CAS  Google Scholar 

  2. Blaustein, M.P., Ector, A.E.: Mol. Pharmacol. 11, 369–378 (1975)

    PubMed  CAS  Google Scholar 

  3. Berde, B., Schild, H.O. (eds.): Ergot alkaloids and related compounds In: Handbook of experimental pharmacology, Vol. 49. Berlin, Heidelberg, New York: Springer 1978

    Google Scholar 

  4. Berntmann, C., Carlsson, C., Siesjö, B.K.: In: Cerebral function, metabolism and circulation. Ingvar, D.H., Lassen, N.A. (eds.), pp. 96–97. Copenhagen: Munksgaard 1977

    Google Scholar 

  5. Capon, A., De Rood, M., Verbist, A., Fruhling, J.: Stroke 8/1, 25–29 (1977)

    Article  Google Scholar 

  6. Cohen, M.M.: In: Models of neurological diseases. Klawans, H.L. (ed.), pp. 201–248. Amsterdam: Excerpta Medica 1974

    Google Scholar 

  7. Fink, B.R., Haschke, R.H.: Anesthesiology 39/2, 199–215 (1973)

    Article  Google Scholar 

  8. Greenberg, D.A., Snyder, S.H.: Life Sci. 20, 927–932 (1977)

    Article  PubMed  CAS  Google Scholar 

  9. Gygax, P., Ruf, G.: New techniques for the isolated perfusion of the rat brain, in preparation (1978)

    Google Scholar 

  10. Gygax, P., Schweizer, A.: Drug Res. 25/10, 1666–1679 (1975)

    Google Scholar 

  11. Gygax, P., Wiernsperger, N.: In: Cerebral function, metabolism and circulation. Ingvar, D.H., Lassen, N.A. (eds.), pp. 116–117. Copenhagen: Munksgaard (1977)

    Google Scholar 

  12. Gygax, P., Emmenegger, H., Dixon, R., Peier, A.: In: Pathology of cerebral microcirculation. Cervos-Navarro, J. (ed.), pp. 386–394. Berlin: Walter de Gruyter 1974

    Google Scholar 

  13. Gygax, P., Stosseck, K., Emmenegger, H., Schweizer, A.: In: Blood flow and metabolism in the brain. Harper, A.M., Jenett, W.B., Miller, J.D., Rowan, J.O. (eds.), pp. 11.14–11.15. Edinburgh: Churchill Livingstone 1975

    Google Scholar 

  14. Gygax, P., Wiernsperger, N., Meier-Ruge, W., Baumann, T.: Gerontology 24, 14–22 (1978)

    Article  PubMed  CAS  Google Scholar 

  15. Haefely, W.E.: Agents and Actions 7/3, 353–359 (1977)

    Article  Google Scholar 

  16. Hossmann, K.-A., Sakaki, S., Zimmermann, V.: In: Cerebral function, metabolism and circulation. Ingvar, D.H., Lassen, N.A. (eds.), pp. 108–109. Copenhagen: Munksgaard 1977

    Google Scholar 

  17. Ingvar, D.H., Lassen, N.A. (eds.): Barbiturate therapy session of the 18th CBF-Symposium. In: Cerebral function, metabolism and circulation, pp. 141–161. Copenhagen: Munksgaard 1977

    Google Scholar 

  18. Kogure, K., Scheinberg, P., Matsumoto, A., Busto, R., Reinmuth, O.: Arch. Neurol. 32, 21–24 (1975)

    PubMed  CAS  Google Scholar 

  19. Kovach, A.G.B.: In: Shock in low- and high-flow states, pp. 65–76. Amsterdam; Excerpta Medica 1971

    Google Scholar 

  20. Kovach, A.G.B.: In: Tissue hypoxia and ischemia. Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds.), pp. 343–370. New York: Plenum Press 1977

    Google Scholar 

  21. Laborit, H., Baron, C., Weber, B.: Agressologie 10/3, 189–239 (1969)

    Google Scholar 

  22. Loew, D.M., Van Deussen, E.B., Meier-Ruge, W.: In: Ergot alkaloids and related compounds. Handbook of experimental pharmacology, Vol. 49, pp. 421–531. Berlin, Heidelberg, New York: Springer 1978

    Google Scholar 

  23. Meier-Ruge, W., Emmenegger, H., Enz, A., Gygax, P., Iwangoff, P., Wiernsperger, N.: Pharmacology 16, 45–62 (1978)

    Article  PubMed  CAS  Google Scholar 

  24. Meyer, J.S., Welch, K.M.A.: In: Neurobiology of aging. Terry, R.D., Gershon, S. (eds.), pp. 121–138. New York: Raven Press 1976

    Google Scholar 

  25. Meyer, J.S., Deshmukh, V.D., Welch, K.M.A.: In: Cerebral arterial disease. Ross Russell, R.W. (ed.), pp. 57–84. Edinburgh: Churchill Livingstone 1976

    Google Scholar 

  26. Michenfelder, J.D., Theye, R.A.: Anesthesiology 33/4, 430–439 (1970)

    Article  Google Scholar 

  27. Michenfelder, J.D., Milde, J.H., Sundt, M.: Arch. Neurol. 33, 345–350

    Google Scholar 

  28. (1976)

    Google Scholar 

  29. Nemoto, E. M., Frank, S.: In: Abstracts of the 62nd Annual FASEB-Meeting, p. 498. Atlantic-City 1978

    Google Scholar 

  30. Nilsson, L.: Acta Neurol. Scand. 47, 233–253 (1971)

    Article  PubMed  CAS  Google Scholar 

  31. Raichle, M.E., Eichling, J.O., Grubb, R.L., Hartmann, B.K.: In: Dynamics of brain edema. Pappius, H.H., Feindel, W. (eds.), pp. 11–17. Berlin, Heidelberg, New York: Springer 1976

    Google Scholar 

  32. Siesjö, B.K., Plum, F.: In: Biology of brain dysfunction. Gaull, G.G. (ed.), Vol. I, pp. 319–372. New York: Plenum Press 1973

    Google Scholar 

  33. Siesjö, B.K., Nilsson, L., Rokeach, M., Nicolaus, N.: In: Brain hypoxia. Brierly, J.B., Meldrum, S. (eds.), pp. 79–93. Philadelphia: Spastics International Medical Publications 1971

    Google Scholar 

  34. Smith, A.L., Marque, J.J.: In: Blood flow and metabolism in the brain. Harper, A.M., Jenett, W.B., Miller, J.D., Rowan, J.O. (eds.), pp. 6.27–6.28. Edinburgh: Churchill Livingstone 1975

    Google Scholar 

  35. Smith, A.L., Hoff, J.T., Nielsen, S.L., Larson, C.P.: Stroke 5/1, 1–7 (1974)

    Article  Google Scholar 

  36. Spano, P.F., Trabucchi, M.: Gerontology 24, 106–114 (1978)

    Article  PubMed  CAS  Google Scholar 

  37. Stosseck, K., Lübbers, D.W., Cottin, N.: Pflügers Arch. Ges. Physiol. 348, 225–238 (1974)

    Article  CAS  Google Scholar 

  38. Symon, L., Astrup, J., Branston, N.M., Lassen, N.A., Strong, A.J.: In: Cerebral vascular disease. Meyer et al. (eds.), pp. 114–118. Amsterdam: Excerpta Medica 1977

    Google Scholar 

  39. Wiernsperger, N., Kunke, S., Gygax, P.: Experientia 32, 671–673 (1976)

    Article  PubMed  CAS  Google Scholar 

  40. Wiernsperger, N., Gygax, P., Meier-Runge, W.: In: Oxygen transport to Tissue III. Silver, I.A., Erecinska, M., Bicher, H.I. (eds.), pp. 605–610. New York: Plenum Press 1978

    Google Scholar 

  41. Williams, L.T., Lefkowitz, R.J.: Science 192, 791–793 (1976).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. Gygax
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Ruf
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Wiernsperger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Baumann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Hirnforschung, Ostmerheimer Str. 200, D-5000, Köln 91, Federal Republic of Germany

    K. J. Zülch

  2. Medizinische Klinik Köln-Merheim und Poliklinik, Universität Köln, Ostmerheimer Str. 200, D-5000, Köln 91, Federal Republic of Germany

    W. Kaufmann

  3. Max-Planck-Institut für Hirnforschung, Forschungsstelle für Hirnkreislauf-Forschung, Ostmerheimer Straße 200, D-5000, Köln 91, Federal Republic of Germany

    K.-A. Hossmann

  4. Medizinische Klinik Köln-Merheim, Lehrstuhl für Innere Medizin II, Universität Köln, Ostmerheimer Straße 200, D-5000, Köln 91, Federal Republic of Germany

    V. Hossmann

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gygax, P., Ruf, G., Wiernsperger, N., Baumann, T. (1979). Effect of Adrenergic Blockade on Cerebral Ischemia. In: Zülch, K.J., Kaufmann, W., Hossmann, KA., Hossmann, V. (eds) Brain and Heart Infarct II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67316-0_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67316-0_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67318-4

  • Online ISBN: 978-3-642-67316-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation