Abstract
The study was designed to ascertain the most effective sodium solution for resuscitation after potentially fatal thermal injury. Solutions containing from 75 to 300 mEq/L of sodium were administered in various doses to mice subjected to a standardized scald. Their effectiveness was evaluated by comparison of the 24-hour mortalities, and also by the changes in body weight, urine and plasma electrolytes, etc. A wide range of solutions was effective: the optimal intake was approximately 22.5 mEq of sodium per kilogram of body weight. This was most efficiently given in a solution containing 225 mEq of sodium and 160 mEq of chloride per liter. Survival increased when the sodium to chloride ratio more closely approximated that of plasma. Hypotonic solutions were less effective at all dosage levels.
Summary of the contribution, Fox, C.L.: Hypertonic Balanced Sodium Solution in Burn Shock. Surgery 60, 348-351 (1975)
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© 1979 Springer-Verlag Berlin Heidelberg
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Fox, C.L. (1979). Hypertonic Balanced Sodium Solution in Burn Shock. In: Tavares, B.M., Frey, R. (eds) Acute Care. Anaesthesiology and Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67211-8_55
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DOI: https://doi.org/10.1007/978-3-642-67211-8_55
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