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Endocrine Responses to Chronic High Altitude Exposure

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Environmental Endocrinology

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

Exposure of animals to hypobaric hypoxia throughout development is a stress that results in a variety of endocrine-related changes. In the rat, neonatal mortality is common at high altitude (HA) with losses as high as 80% by weaning age (CHIODI, 1964; KELLEY and PACE, 1968; NELSON and CONS, 1975). Altered activity of several endocrine organs has been reported in those rats which survive.

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References

  • Abelson, A.E.: Altitude and fertility. Human Biol. 48, 83–91 (1976)

    PubMed  CAS  Google Scholar 

  • Chiodi, H.: Action of high altitude chronic hypoxia on newborn animals. In: The Physiological Effects of High Altitude. Weihe, W.H. (ed.). New York: Macmillan, 1964, pp. 97–112

    Google Scholar 

  • Donayre, J.: Population growth and fertility at high altitude. In: Life at High Altitudes. Hurtado, A. (ed.). Washington, D.C.: Pan Am. Health Org., 1966, pp. 74–79

    Google Scholar 

  • Gordon, A.S., Tornetta, F.J., D’angelo, S.A., Charipper, H.A.: Effects of low atmospheric pressures on the activity of the thyroid, reproductive system and anterior lobe of the pituitary in the rat. Endocrinology 33, 366–383 (1943)

    Article  CAS  Google Scholar 

  • Kelley, F.C., Pace, N.: Etiological considerations in neonatal mortality among rats at moderate high altitude (3,800 m). Am. J. Physiol. 214, 1168–1175 (1968)

    PubMed  CAS  Google Scholar 

  • Middlesworth, L. Van, Berry, M.M.: Iodide metabolism during anoxia, nephrectomy, trauma, avitaminoses and starvation in the rat. Am. J. Physiol. 167, 576–580 (1951)

    Google Scholar 

  • Moore, C.R., Price, D.: A study at high altitude of reproduction, growth, sexual maturity, and organ weights. J. Exp. Zool. 108, 171–216 (1948)

    Article  PubMed  CAS  Google Scholar 

  • Nelson, M.L.: Thyroid function in immature rats developing at high altitude. Environ. Physiol. Biochem. 1, 96–103 (1971)

    Google Scholar 

  • Nelson, M.L.: Microscopic appearance of the anterior pituitary gland in rats born and raised at high altitude (3800 m). Pacific Regional Conf. Gen. Comp. Endocrinol. Abstracts 39 (1973)

    Google Scholar 

  • Nelson, M.L., Cons, J.M.: Pituitary hormones and growth retardation in rats raised at simulated high altitude (3800 m). Environ. Physiol. Biochem. 5, 273–282 (1975)

    PubMed  CAS  Google Scholar 

  • Nelson, M.L., Srebnik, H.H.: Comparison of the reproductive performance of rats at high altitude (3800 m) and at sea level. Int. J. Biometeorol. 14, 187–193 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Nelson, M.L., Srebnik, H.H., Timiras, P.S.: Reduction in pituitary growth hormone and thyroid-stimulating hormone at high altitude. Excerpta Med. Int. Cong. Ser. 157, 196 (1968)

    Google Scholar 

  • Pawson, I.G.: Growth and development in high altitude populations: a review of Ethiopian, Peruvian and Nepalese studies. Proc. R. Soc. Lond. (Biol.) 194, 83–98 (1976)

    Article  CAS  Google Scholar 

  • Surks, M.I.: Effect of hypoxia and high altitude on thyroidal iodine metabolism. Endocrinology 78, 307–315 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Timiras, P.S., Woolley, D.E.: Functional and morphologic development of brain and other organs of rats at high altitude. Federation Proc. 25, 1312–1320 (1966)

    CAS  Google Scholar 

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© 1978 Springer-Verlag Berlin Heidelberg

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Nelson, M.L. (1978). Endocrine Responses to Chronic High Altitude Exposure. In: Assenmacher, I., Farner, D.S. (eds) Environmental Endocrinology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66981-1_45

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  • DOI: https://doi.org/10.1007/978-3-642-66981-1_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66983-5

  • Online ISBN: 978-3-642-66981-1

  • eBook Packages: Springer Book Archive

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