Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a contaminant of some herbicides, is an extremely potent enzyme inducer. Male albino rats of two genetically different substrains developed for the inducibility (RR) and non-inducibility (rr) of aldehyde dehydrogenase by phenobarbital were given TCDD 80 μg/kg as a single dose 6 days before analysis. rr-Animals having no induction of the hepatic soluble high-Km aldehyde dehydrogenase by phenobarbital showed an approximate 25-fold increase in activity after TCDD treatment. The increase in aldehyde dehydrogenase activity could be detected only when measured with a millimolar substrate concentration. The aldehyde dehydrogenase activity in serum was increased 3-fold after TCDD administration in both substrains.
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Marselos, M., Törrönen, R. (1978). Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment. In: Leonard, B.J. (eds) Toxicological Aspects of Food Safety. Archives of Toxicology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66896-8_52
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DOI: https://doi.org/10.1007/978-3-642-66896-8_52
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