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The Pathogenesis of Experimental Acute Renal Failure: The Role of Membrane Dysfunction

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Progress in Molecular and Subcellular Biology

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 5))

Abstract

The mechanism responsible for the pathogenesis of acute renal failure, a disease characterized by the sudden loss of renal function, continues to be the subject of controversy. The maintained high morbidity and mortality, despite numerous clinical advances in its treatment as well as the renewed scientific interest in its pathogenesis, suggests that a detailed knowledge of the pathophysiologic mechanisms will be required before significant progress in the prevention and/or treatment of acute renal failure will be forthcoming. The controversy appears to have persisted, despite the availability of sophisticated investigative techniques, because of the lack of a single experimental model or a single pathophysiologic mechanism that best explains the observed abnormalities in renal function.

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References

  • AYER, G., GRANDCHAMP, A., WYLER, J., TRUNIGER, B.: Intrarenal hemodynamics in glycerol-induced myohemoglobinuric acute renal failure in the rat. Circ. Res. 29, 128–135 (1971).

    PubMed  CAS  Google Scholar 

  • BAINES, A.D.: Redistribution of nephron function in response to chronic and acute saline loads. Am. J. Physiol. 224, 237–244 (1973).

    PubMed  CAS  Google Scholar 

  • BARENBERG, R.L., SOLOMON, S., PAPPER, S., ANDERSON, R.: Clearance and micropuncture study of renal function in mercuric chloride treated rats. J. Lab. Clin. Med. 72, 473–484 (1968).

    PubMed  CAS  Google Scholar 

  • BARRATT, L.J., WALLIN, J.D., RECTOR, F.C., SELDIN, D.W.: Influence of volume on single nephron filtration rate and plasma flow in the rat. Am. J. Physiol. 224, 643–650 (1973).

    PubMed  CAS  Google Scholar 

  • BARRON, E.S.G., MUNTZ, J.A., GASVODA, B.: Regulatory mechanisms of cellular respiration. I.: The role of cell membranes; uranium inhibition of cellular respiration. J. Gen. Physiol. 32, 163–178 (1948).

    Article  PubMed  CAS  Google Scholar 

  • BEEUWKES, R.: Efferent vascular patterns and early vascular-tubular relations in the dog. Am. J. Physiol. 221, 1361–1374 (1971).

    PubMed  Google Scholar 

  • BEEUWKES, R., BONVENTRE, J.: Tubular organization and vascular-tubular relations in the dog. Am. J. Physiol. 229, 695–713 (1975).

    PubMed  Google Scholar 

  • BIBER, T.U., MYLLE, M., BAINES, A.D., GOTTSCHALK, C.W.: A study by micropuncture and microdissection of acute renal damage in rats. Am. J. Med. 44, 664–705 (1968).

    Article  PubMed  CAS  Google Scholar 

  • BRENNER, B.M., FALCHUK, K.W., KEIMOWITZ, R.I., BERLINER, R.W.: The relationship between peritubular capillary protein concentration and fluid reabsorption by the renal proximal tubule. J. Clin. Invest. 48, 1519–1531 (1969).

    Article  PubMed  CAS  Google Scholar 

  • BRENNER, B.M., TROY, J.L., DAUGHARTY, T.M., DEEN, W.M., ROBERTSON, C.R.: Dynamics of glomerular ultrafiltration in the rat. II.: Plasma-flow dependence of GFR. Am. J. Physiol. 223, 1184–1190 (1972).

    PubMed  CAS  Google Scholar 

  • BROWN, J.J., GLEADLE, R.I., LAWSON, D.H., LEVER, A.F., LINTON, A.L., MACADAM, R.F., PRENTICE, E., ROBERTSON, J.I.S., TREE, M.: Renin and acute renal failure: Studies in man. Brit. J. Med. 1, 253–258 (1970).

    Article  Google Scholar 

  • BROWN, J.J., CHINN, R.H., GAAVRAS, H., LECKE, B., LEVER, A.F., MACGREGOR, J., MORTON, J., ROBERTSON, J.I.S.: Renin and renal function. In: Hypertension (Eds. J. Genest, E. Karuv). Berlin: Springer 1972.

    Google Scholar 

  • BROWN, W.C.B., BROWN, J.J., GAVRAS, H., POWELL-JACKSON, J.D., LEVER, A.F., MACGREGOR, J., MACADAM, R.F., ROBERTSON, J.I.S.: Renin and acute circulatory renal failure in the rabbit. Circ. Res. 30, 114–122 (1972).

    PubMed  CAS  Google Scholar 

  • BRUNS, F.J., ALEXANDER, E.A., RILEY, A.L., LEVINSKY, N.G.: Superficial and juxtamedullary nephron function during saline loading in the dog. J. Clin. Invest. 53, 971–979 (1974).

    Article  PubMed  CAS  Google Scholar 

  • BULL, C.M., JOEKES, A.M., LOWE, K.G.: Renal function studies in acute tubular necrosis. Clin. Sci. 9, 379–403 (1950).

    Google Scholar 

  • BUNAG, R.D., PAGE, I.H., MCCUBBIN, W.J.: Neural stimulation of renin release. Circ. Res. 19, 851–858 (1966).

    PubMed  CAS  Google Scholar 

  • CHEDRU, M.F., BAETHKE, R., OKEN, D.E.: Renal cortical blood flow and glomerular filtration in myohemoglobinuric acute renal failure. Kidney Int. 1, 232–239 (1972).

    Article  PubMed  CAS  Google Scholar 

  • CLELAND, W.W.: Dithiothreitol, a new protective agent for SH groups. Biochemistry 3, 480–482 (1964).

    Article  PubMed  CAS  Google Scholar 

  • CLEMENT, D.L., PELLETIER, C.L., SHEPERD, J.T.: Role of vagal afferents in the control of renal sympathetic activity in the rabbit. Circ. Res. 31, 824–830 (1972);.

    PubMed  CAS  Google Scholar 

  • COOK, W.F.: Cellular localization of renin. In: Kidney Hormones (Ed. J.W. FISCHER), New York: Little, Brown 1971.

    Google Scholar 

  • CORTNEY, M.A., NAGLE, W., THURAU, K.: A micropuncture study of the relationship between flow rate through the loop of Henle and sodium concentration in the early distal tubule. Pflug. Arch. 287, 286–295 (1966).

    Article  CAS  Google Scholar 

  • DAHLHEIM, H., GRANGER, P., THURAU, K.: A sensitive method for determination of renin activity in the single juxtaglomerular apparatus of the rat kidney. Pflug. Arch. Europ. J. Physiol. 321, 303–315 (1970).

    Article  CAS  Google Scholar 

  • DAUGHARTY, T.M., VEKI, I.F., MERCER, P.F., BRENNER, B.M.: Dynamics of glomerular filtration in the rat. V.: Response to ischemic injury. J. Clin. Invest. 53, 105–116 (1974).

    Article  PubMed  CAS  Google Scholar 

  • DAVIS, J.O.: What signals the kidney to release renin? Circ. Res. 28, 301–306 (1971).

    PubMed  CAS  Google Scholar 

  • DEEN, W.M., ROBERTSON, C.R., BRENNER, B.M.: Trans capillary fluid exchange in the renal cortex. Circ. Res. 33, 1–8 (1973).

    PubMed  CAS  Google Scholar 

  • DEMIS, D.J., ROTHENSTEIN, A., MEIER, R.: The relationship of the cell surface to metabolism. X.: The location and function of invertase in the yeast cell. Arch. Biochem. 48, 55–62 (1954).

    Article  PubMed  CAS  Google Scholar 

  • DEV, B., DRESCHER, C., SCHNERMANN, J.: Resetting of tubuloglomerular feedback sensitivity by the dietary salt intake. Pflug. Arch. 346, 263–277 (1974).

    Article  CAS  Google Scholar 

  • DIBONA, G.F., MCDONALD, F., FLAMENBAUM, W., DAMMON, G.J., OKEN, D.E.: Maintenance of renal function in salt loaded rats despite severe tubular necrosis induced by HgCl2. Nephron 8, 205–220 (1971).

    Article  PubMed  CAS  Google Scholar 

  • DIBONA, C.F., SAWIN, L.L.: The renin-angiotensin system in acute renal failure in the rat. Lab. Invest. 25, 528–532 (1971).

    PubMed  CAS  Google Scholar 

  • FINKIELMAN, S., GOLDSTEIN, D.J., FISCHER-FENARO, C, NAHNOL, V.F.: In vitro production of angiotensin and renin release by isolated glomeruli. Medicine (Buenos Aires) 32, (suppl I) 37–39 (1972).

    CAS  Google Scholar 

  • FINN, A.L.: Separate effects of sodium and vasopressin on the sodium pump in toad bladder. Am. J. Physiol. 215, 849–856 (1968).

    PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W.: Pathophysiology of acute renal failure. Arch. Intern. Med. (Chicago) 131, 911–928 (1973).

    CAS  Google Scholar 

  • FLAMENBAUM, W., HAMBURGER, R.J.: Superficial and deep juxtaglomerular apparatus renin activity of the rat kidney: Effect of surgical preparation and NaCl intake. J. Clin. Invest. 54, 1373–1381 (1974).

    Article  PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W., HAMBURGER, R.J., HUDDLESTON, M.L., KAUFMAN, J., MCNEIL, J.S., SCHWARTZ, J.H., NAGLE, R.: The initiation phase of experimental acute renal failure: an evaluation of uranyl nitrate-induced acute renal failure in the rat. Kidney Int. (in press).

    Google Scholar 

  • FLAMENBAUM, W., HUDDLESTON, M.L., MCNEIL, J.S., HAMBURGER, R.J.: Uranyl nitrate-induced acute renal failure in the rat: micropuncture and renal hemodynamic studies. Kidney Int. 6, 408–418 (1974).

    Article  PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W., KOTCHEN, T.A., OKEN, D.E.: Effect of renin immunization on mercuric chloride and glycerol-induced renal failure. Kidney Int. 1, 406–412 (1972a).

    Article  PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W., MCDONALD, F.D., DIBONA, G.F., OKEN, D.E.: Micro-puncture study of renal tubular factors in low dose mercury poisoning. Nephron 8, 221–234 (1971).

    Article  PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W., MCNEIL, J.S., KOTCHEN, T.A., LOWENTHAL, D., NAGLE, R.B.: Glycerol-induced acute renal failure after plasma renin activity suppression. J. Lab. Clin. Med. 82, 587–596 (1973).

    PubMed  CAS  Google Scholar 

  • FLAMENBAUM, W., MCNEIL, J.S., KOTCHEN, T.A., SALADINO, A.J.: Experimental acute renal failure induced by uranyl nitrate in the dog. Circ. Res. 31, 682–698 (1972b).

    PubMed  CAS  Google Scholar 

  • FLANNIGAN, W.J., OKEN, D.E.: Renal micropuncture study of the development of anuria in the rat with mercury induced acute renal failure. J. Clin. Invest. 44, 449–457 (1965).

    Article  Google Scholar 

  • FRENKEL, A., EKBALD, E.B.M., EDELMAN, I.S.: Effects of sulfhydryl reagents on basal and vasopressin-stimulated Na+ transport in the toad bladder. In: Biomembranes 7, (Eds. H. Eisenberg, E. Katachelski-Katzir, L.A. Manson). New York: Plenum Press 1975.

    Google Scholar 

  • GAVRAS, H., BROWN, J.J., LEVER, A.F., ROBERTSON, J.I.S.: Changes of renin in individual glomeruli in response to variations of sodium intake. Clin. Sci. 38, 409–414 (1970).

    PubMed  CAS  Google Scholar 

  • GILMORE, J.P.: Contribution of baroreceptors to the control of renal function. Circ. Res. 14, 301–317 (1964).

    PubMed  CAS  Google Scholar 

  • GOORMAGHTIGH, N.: Histologic changes in the ischemic kidney, with special reference to the juxtaglomerular apparatus. Am. J. Pathol. 16, 409–416 (1940).

    PubMed  CAS  Google Scholar 

  • GOORMAGHTIGH, N.: Vascular and circulatory changes in renal cortex in anuric crush-syndrome. Proc. Soc. Exp. Biol. Med. 59, 303–305 (1945).

    Google Scholar 

  • GOORMAGHTIGH, N.: The renal arteriolar changes in the anuric crush syndrome. Am. J. Pathol. 23, 513–529 (1947).

    PubMed  CAS  Google Scholar 

  • GRANGER, P., DAHLHEIM, H., THURAU, K.: Enzyme activity of single juxtaglomerular apparatuses in the rat kidney. Kidney Int. 1, 77–88 (1972).

    Article  Google Scholar 

  • HENRY, L.N., LANE, C.E., KASHGARIAN, M.: Micropuncture studies of the pathophysiology of acute renal failure in the rat. Lab. Invest. 19, 309–314 (1968).

    CAS  Google Scholar 

  • HIRSCHORN, N., FRAZIER, H.S.: Intracellular electrical potential of the epithelium of turtle bladder. Am. J. Physiol. 220, 1158–1161 (1971).

    Google Scholar 

  • HOLLENBERG, N., ADAMS, D.F., OKEN, D.E., ABRAMS, H.L., MERRILL, J.P.: Acute renal failure due to nephrotoxins. Renal hemodynamics and angiographic studies in man. New Engl. J. Med. 282, 1329–1334 (1970).

    Article  PubMed  CAS  Google Scholar 

  • HOLLENBERG, N.K., EPSTEIN, M., ROSEN, M., BASON, R.R., OKEN, D.E., MERRILL, J.P.: Acute oliguric renal failure in man: evidence for preferential renal cortical ischemia. Medicine (Baltimore) 47, 455–474 (1968).

    Article  CAS  Google Scholar 

  • JAENIKE, J.R.: Micropuncture study of methemoglobin-induced renal failure in the rat. J. Lab. Clin. Med. 73, 459–468 (1969).

    PubMed  CAS  Google Scholar 

  • JAMISON, R.L.: Micropuncture study of superficial and juxtamedullary nephrons in the rat. Am. J. Physiol. 218, 46–55 (1970).

    PubMed  CAS  Google Scholar 

  • JAMISON, R.L., LACY, F.B.: Effect of saline infusion on superficial and juxtamedullary nephrons in the rat. Am. J. Physiol. 221, 690–697 (1971).

    PubMed  CAS  Google Scholar 

  • JOHNSON, J.A., DAVIS, J.O., WITTY, R.T.: Effects of catecholamines and renal nerve stimulation on renin release in the non-filtering kidney. Circ. Res. 29, 646–653 (1971).

    PubMed  CAS  Google Scholar 

  • KEZDI, P., GELLER, E.: Baroreceptor control of post-ganglionic sympathetic nerve discharge. Am. J. Physiol. 214, 427–435 (1968).

    PubMed  CAS  Google Scholar 

  • KLEINMAN, J.G., MCNEIL, J.S., FLAMENBAUM, W.: Uranyl nitrate acute renal failure in the dog: early changes in renal function and hemodynamics. Clin. Sci. Mol. Med. 48, 9–19 (1975).

    PubMed  CAS  Google Scholar 

  • LADEFOGED, J., WINKLER, K.: Hemodynamics and acute renal failure. The effect of hypotension induced by hydralazine on renal blood flow, mean circulation time for plasma, and renal vascular volume in patients with acute oliguric renal failure. Scand. J. Clin. Lab. Invest. 26, 83–87 (1970).

    Article  PubMed  CAS  Google Scholar 

  • LAGRANGE, R.G., SLOOP, C.H., SCHMIDT, H.B.: Selective stimulation of renal nerves in the anesthetized dog. Effect on renin release during controlled changes in renal hemodynamics. Circ. Res. 33, 704–712 (1973).

    CAS  Google Scholar 

  • LARAGH, J.H., SEALEY, J.E.: The renin-angiotensin-aldosterone hormonal system and regulation of sodium, potassium and blood pressure homeostasis. In: Handbook of Physiology (Eds. J. Orloff, R.W. Berliner), Sect. VIII. Baltimore: Williams and Wilkins Co. 1973.

    Google Scholar 

  • LESLIE, B.R., SCHWARTZ, J.H., STEINMETZ, P.R.: Coupling between Cl-absorption and HCO3- secretion in turtle urinary bladder. Am. J. Physiol. 225, 610–617 (1973).

    PubMed  CAS  Google Scholar 

  • LEVER, A.F., PEART, W.S.: Renin and angiotensin-like activity in renal lymph. J. Physiol. (Lond.) 160, 548–563 (1972).

    Google Scholar 

  • LICHTENSTEIN, N.F., LEAF, A.: Effect of amphotericin B on the permeability of toad bladder. J. Clin. Invest. 44, 1328–1342 (1969).

    Article  Google Scholar 

  • LJUNGQVIST, A.: Ultrastructural demonstration of a connection between afferent and efferent juxtaglomerular arterioles. Kidney Int..8, 239–244 (1975).

    Article  PubMed  CAS  Google Scholar 

  • LJUNGQVIST, A., WAGERMARK, J.: Adrenergic innervation of intrarenal glomerular and extraglomerular circulatory routes. Nephron 7, 218–229 (1970).

    Article  PubMed  CAS  Google Scholar 

  • LOGAN, A., JOSE, P., EISNER, G., LILLIENFIELD, L., SLOTKOFF, L.: Intracortical distribution of renal blood flow in hemorrhagic shock in dogs. Circ. Res. 29, 257–266 (1971).

    PubMed  CAS  Google Scholar 

  • MASSANI, Z.M., FINKIELMAN, S., WORCEL, M., AGREST, A., PALADINI, A.C.: Angiotensin blood levels in hypertensive and nonhypertensive disease. Clin. Sci. 30, 473–483 (1966).

    PubMed  CAS  Google Scholar 

  • MATHEWS, P.G., MORGAN, T.O., JOHNSTON, C.I.: The renin-angiotensin system in acute renal failure in rats. Clin. Sci. Mol. Med. 47, 79–88 (1974).

    Google Scholar 

  • MCDONALD, F.D., THIEL, G., WILSON, R.D., DíBONA, G.F., OKEN, D.E.: The prevention of acute renal failure in the rat by long term saline loading. A possible role of the renin-angiotensin axis. Proc. Soc. Exp. Biol. Med. 131, 610–614 (1969).

    PubMed  CAS  Google Scholar 

  • MENDELSOHN, F.A.O., JOHNSTON, C.I.: Composition of juxtaglomerular granules. In vitro presence of angiotensin immunoactive substance. Proc. 5th Int. Cong. Nephrol. Mexico City, 1972.

    Google Scholar 

  • MERRILL, J.P.: Kidney disease: acute renal failure. Ann. Rev. Med. 11, 127–150 (1960).

    Article  Google Scholar 

  • MERRILL, J.P.: Acute renal failure. In: Disease of the Kidney (Eds. M.B. STRAUSS, L.G. WELT), 2nd ed., pp. 637–666. Boston: Little, Brown and Co. 1971.

    Google Scholar 

  • MOGIL, R.A., ITSKOWITZ, H., RUSSELL, J.H., MURPHY, J.J.: Renal innervation and renin activity in salt metabolism and hypertension. Am. J. Physiol. 216, 693–697 (1969).

    PubMed  CAS  Google Scholar 

  • NAVAR, L.G., BURKE, T.J., ROBINSON, R.R., CLAPP, J.R.: Distal tubular feedback in the autoregulation of single nephron filtration rate. J. Clin. Invest. 53, 516–525 (1974).

    Article  PubMed  CAS  Google Scholar 

  • NINOMIYA, I., IRISAWA, H.: Summation of baroreceptor reflex effects on sympathetic nerve activity. Am. J. Physiol. 216, 1330–1336 (1969).

    PubMed  CAS  Google Scholar 

  • NINOMIYA, I., NISIMARU, N., IRISAWA, H.: Sympathetic nerve activity to the spleen, kidney and heart in response to baroreceptor input. Am. J. Physiol. 221, 1346–1351 (1971).

    PubMed  CAS  Google Scholar 

  • NORBY, L.E., AL-AWQATI, Q., MULLER, A., STEINMETZ, P.R.: Separate stimulation of H+ secretion and Na+ absorption by aldosterone in turtle bladder. Clin. Res. 23, 371A (1975).

    Google Scholar 

  • OCHOA, E., FINKIELMAN, S., AGREST, A.: Angiotensin blood levels during the evolution of acute renal failure. Clin. Sci. 38, 225–231 (1970).

    PubMed  CAS  Google Scholar 

  • OKEN, D.E., ARCE, M.L., WILSON, D.R.: Glycerol-induced hemoglobinuric acute renal failure in the rat. I.: Micropuncture study of the development of oliguria. J. Clin. Invest. 45, 724–735 (1966).

    Article  PubMed  CAS  Google Scholar 

  • OKEN, D.E., COATES, S.C., FLAMENBAUM, W., POWELL-JACKSON, J.D., LEVER, A.F.: Active and passive immunization to angiotensin in experimental acute renal failure. Kidney Int. 7, 12–18 (1975a).

    Article  PubMed  CAS  Google Scholar 

  • OKEN, D.E., MENDE, C.W., TARABA, I., FLAMENBAUM, W.: Resistance to acute renal failure by prior renal failure: examination of the role of renal renin content. Nephron 15, 131–142 (1975b).

    Article  PubMed  CAS  Google Scholar 

  • OSBORNE, M.J., DROZ, B., MEYER, P., MOREL, F.: Angiotensin II: renal localization in glomerular mesangial cells by autoradiography. Kidney Int. 8, 245–254 (1975).

    Article  PubMed  CAS  Google Scholar 

  • PAGE, I.H., MCCUBBIN, J.W.: Renal Hypertension. Chicago: Yearbook Medical Publ. Inc. 1968.

    Google Scholar 

  • PAPPER, S.: Renal failure. Med. Clin. N. Am. 55, 335–357 (1971).

    PubMed  CAS  Google Scholar 

  • PEDERSON, F., LADEFOGED, J.: Renal hemodynamics in acute renal failure in man measured by intra-arterial injection. External counting with Xenon-133 and I-131-albumin. Scand. J. Urol. Nephrol. 7, 187–195 (1973).

    Article  Google Scholar 

  • POMERANZ, B.H., BIRTCH, A.G., BARGER, A.C.: Neural control of intrarenal blood flow. Am. J. Physiol. 215, 1067–1081 (1968).

    PubMed  CAS  Google Scholar 

  • POWELL-JACKSON, J.D., BROWN, J.J., LEVER, A.F., MACGREGOR, J., MACADAM, R.F., TITTERINGTON, D.M., ROBERTSON, J.I.S., WAITE, M.A.: Protection against acute renal failure in rats by passive immunization against angiotensin II. Lancet 1, 774–776 (1972).

    Article  PubMed  CAS  Google Scholar 

  • RAUGH, W.H., OSTER, P., DIETZ, R., GROSS, I.: Angiotensin II in acute renal failure in the rat. Acta Endocrinol. 73, (suppl 177) 193 (1973).

    Google Scholar 

  • REUBI, F.C., GOSSWEILER, N., GURTLER, R.: A dye dilution method of measuring renal blood flow in man with special reference to the anuric subject. Proc. Soc. Exp. Biol. Med. 111, 760–765 (1962).

    PubMed  CAS  Google Scholar 

  • REUSS, L., FINN, A.L.: Dependence of serosal membrane potential on mucosal membrane potential in toad urinary bladder. Biophys. J. 15, 71–75 (1975).

    Article  PubMed  CAS  Google Scholar 

  • RIGGS, A.: The oxygen equilibrium of the hemoglobin of the eel. J. Gen. Physiol. 35, 41–44 (1952).

    Article  Google Scholar 

  • RIGGS, A.: Hemoglobin structure. In: Sulfur Protein (Ed. R. Benesch), p. 173. New York: Academic Press 1959.

    Google Scholar 

  • RIGGS, A., WALBACH, R.A.: Sulfhydryl groups and the structure of hemoglobin. J. Gen. Physiol. 39, 585–605 (1956).

    Article  PubMed  CAS  Google Scholar 

  • ROTHSEIN, A.: Cell membrane as a site of action of heavy metals. Fed. Proc. 18, 1026–1035 (1959).

    Google Scholar 

  • RUIZ-GUINAZU, A.: Alterations of the glomerular filtration rate in acute renal failure. In: Pathogenesis and Clinical Findings with Renal Failure (Eds. U. GESSLER, K. SCHROEDER, H. WEIDINGER), pp. 23–32. Stuttgart: Georg Thieme 1971.

    Google Scholar 

  • RYAN, R., MCNEIL, J.S., FLAMENBAUM, W.: Uranyl nitrate-induced acute renal failure in the rat: effect of varying doses and saline loading. Proc. Soc. Exp. Biol. Med. 143, 289–296 (1973).

    PubMed  CAS  Google Scholar 

  • SCHNERMANN, J., DAVIS, J.M., WUNDERLICH, P., LEVINE, D.Z., HORSTER, M.: Technical problems in the micropuncture determination of nephron filtration rate and their functional implications. Pflug. Arch. 329, 307–320 (1971).

    Article  CAS  Google Scholar 

  • SCHNERMANN, J. PERSSON, A.E.G.., AGERUP, B.: Tubuloglomerular feedback. Nonlinear relation between glomerular hydrostatic pressure and loop of Henle perfusion rate. J. Clin. Invest. 52, 862–869 (1973).

    Article  PubMed  CAS  Google Scholar 

  • SCHNERMANN, J., NAGEL, W., THURAU, K.: Die fruhdistale Natriumkonzentration in Rattenieren nach Renaler Ischamie und hemorrhagischer Hypotension. Ein Beitrag zur Pathogenese der postischamischen und posthemorrhagischen Filtraterniedrigung. Pflug. Arch. 287, 296–310 (1966).

    Article  CAS  Google Scholar 

  • SCHNERMANN, J., WRIGHT, F.S., DAVIS, J.M., STACKELBERG, W.V., GRILL, G.: Regulation of superficial nephron filtration rate by tubuloglomerular Pflug. Arch. 318, 147–175 (1970).

    Article  CAS  Google Scholar 

  • SCHWARTZ, J.H.: H+ current response to CO2 and carbonic anhydrase inhibitors by the turtle urinary bladder. Am. J. Physiol, (in press).

    Google Scholar 

  • SCHWARTZ, J.H., FLAMENBAUM, W.: Heavy metal induced alterations in ion transport by the turtle urinary bladder. Am. J. Physiol, (in press).

    Google Scholar 

  • SEVITT, S.: Pathogenesis of traumatic uremia. A revised concept. Lancet 2, 135–1141 (1959).

    Article  PubMed  CAS  Google Scholar 

  • STEINHAUSEN, M., EISENBACH, G.M., HELMSTADLER, V.: Concentration of lissamine green in proximal tubules of antidiuretic and mercury poisoned rats. Pflug. Arch. 311, 1–15 (1969).

    Article  CAS  Google Scholar 

  • STEINMETZ, P.R.; Cellular mechanisms of urinary acidification. Physiol. Rev. 54, 890–956 (1974).

    PubMed  CAS  Google Scholar 

  • STEINMETZ, P.R., LAWSON, L.R.: Defect in urinary acidification induced by amphotericin B. J. Clin. Invest. 49, 596–601 (1970).

    Article  PubMed  CAS  Google Scholar 

  • STEINMETZ, P.R., LAWSON, L.R.: Affect of luminal pH on ion permeability and flow of Na+ and H+ in turtle bladder. Am. J. Physiol. 220, 1573–1580 (1971).

    PubMed  CAS  Google Scholar 

  • STUMPE, K.O., LOWITZ, H.D., OCHWALD, B.: Function of the juxta-medullary nephrons in normotensive and chronically hypertensive rats. Pflug. Arch. Ges. Physiol. 313, 43–52 (1969).

    Article  CAS  Google Scholar 

  • SUTHERLAND, L.E.: Fluorescent antibody study of juxtaglomerular space cells using the freeze-substitution technique. Nephron 7, 512–523 (1970).

    Article  PubMed  CAS  Google Scholar 

  • SWANN, R.C., MERRILL, J.P.: The clinical course of acute renal failure. Medicine (Baltimore) 32, 215–292 (1953).

    CAS  Google Scholar 

  • TAKABATAKE, T., MASON, J., FLAMENBAUM, W., THURAU, K.: Micropuncture Investigation in Acute Renal Failure. Tenth Gesellschaft fur Nephrologie, Innsbruck, 1974.

    Google Scholar 

  • THIEL, G., MCDONALD, F.D., OKEN, D.E.: Micropuncture studies of the basis for protection of renin depleted rats from glycerol-induced acute renal failure. Nephron 7, 67–79 (1970).

    Article  PubMed  CAS  Google Scholar 

  • THORBURN, G.D., KOPALD, H.H., HERD, J.A., HOLLENBERG, N., O’MORCHOE, C.C.C., BARGER, A.C.: Intrarenal distribution of nutrient blood flow determined with Kr85 in the unanesthetized dog. Circ. Res. 13, 290–305 (1963).

    PubMed  CAS  Google Scholar 

  • THURAU, K.: Influence of sodium concentration at macula densa cells on tubular sodium load. Ann. N.Y. Acad. Sci. 139, 388–399 (1966).

    Article  PubMed  CAS  Google Scholar 

  • THURAU, K.: Pathophysiologie des akuten Nierenversagen. In: Anaesthesiologie und Wiederbelegung. Vol. 49, Intensivtherapie beim akuten Nierenversagen, pp. 1–18. Berlin: Springer-Verlag 1970.

    Google Scholar 

  • THURAU, K.: The juxtaglomerular apparatus: its role in the function of the single nephron unit. In: Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease. Int. Cong. Series No. 268, pp. 84–93. Amsterdam: Excerpta Medica 1972a.

    Google Scholar 

  • THURAU, K.: Aspects in renal physiology. Klin. Wschr. 50, 221–225 (1972b).

    Article  PubMed  CAS  Google Scholar 

  • THURAU, K.W.C., DAHLHEIM, H., GRUNER, A., MASON, J., GRANGER, P.: Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa. Circ. Res. 30–31, (suppl II) 182–186 (1972).

    Google Scholar 

  • THURAU, K., MASON, J.: The intrarenal function of the juxtaglomerular apparatus. In: Kidney and Urinary Tract Physiology, MTP International Review of Science, Physiology Ser. 1, vol. VI, pp. 357–390. London: Butterworth and Co. 1974.

    Google Scholar 

  • THURAU, K., SCHNERMANN, J.: Die Natriumkonzentration an den Macula densa-Zellen als regulierender Faktor fur das Glomerulum filtrat (Mikropunktionversuche). Klin. Wschr. 43, 410–413 (1965).

    Article  PubMed  CAS  Google Scholar 

  • TU, W.H.: Plasma renin activity in acute tubular necrosis and other renal diseases associated with hypertension. Circulation 31, 686–695 (1965).

    PubMed  CAS  Google Scholar 

  • WALLIN, J.D., BLANTZ, R.C., KATZ, M.A., ANDREUCCI, V.E., RECTOR, F.C., SELDIN, D.W.: Effect of saline diuresis on intrarenal blood flow in the rat. Am. J. Physiol. 221, 1297–1304 (1971).

    PubMed  CAS  Google Scholar 

  • WEBB, J.L.: Enzyme and Metabolic Inhibitors, vol. II, p. 1237. New York: Academic Press 1966.

    Google Scholar 

  • WIRZ, H.R., DIRIX, R.: Urinary concentration and dilution. In: Handbook of Physiology, Sect. VIII (Eds. J. ORLOFF, R.W. BERLINER). Baltimore: Williams and Wilkins Co. 1973.

    Google Scholar 

  • WRIGHT, F.S., SCHNERMANN, J.: Interference with feedback control of glomerular filtration rate by furosemide, triflocin and cyanide. J. Clin. Invest. 53, 1695–1708 (1974).

    Article  PubMed  CAS  Google Scholar 

  • ZEHR, J.E., FEIGL, E.O.: Suppression of renin activity by hypothalamic stimulation. Circ. Res. 32, (suppl I) 17–27 (1973).

    PubMed  Google Scholar 

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Authors
  1. Walter Flamenbaum
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  2. John H. Schwartz
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  3. Robert J. Hamburger
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  4. James S. Kaufman
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Editors and Affiliations

  1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Flamenbaum, W., Schwartz, J.H., Hamburger, R.J., Kaufman, J.S. (1977). The Pathogenesis of Experimental Acute Renal Failure: The Role of Membrane Dysfunction. In: Hahn, F.E., Kersten, H., Kersten, W., Szybalski, W. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66626-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-66626-1_3

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